Intrauterine Autologous PRP Infusion Compared to HRT for Enhancing Endometrial Thickness in Patients Undergoing ICSI
Phase 1
- Conditions
- Infertility
- Interventions
- Biological: platlet rich plasma
- Registration Number
- NCT02660294
- Lead Sponsor
- Ain Shams University
- Brief Summary
Successful embryo implantation needs an optimum embryonic development with a receptive endometrium. Endometrial thickness is an independant factor for endometrial receiptivity. The aim of that trial is to assess the benefecial effect of platelt rich plasma in copmarison with standard hormonal therapy.
- Detailed Description
This is a single blinded randomized trial comparing the effect of of platlet rich plasma versus hormonal therapy on endometrial thickness and consequently endometrial receptivity. The primary endpoint of this trial is clinical pregnancy rate.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
- patients undergoing ICSI
- endometrial thickness less than 7 mm on early follicular phase
Exclusion Criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Platlet rich plasma platlet rich plasma For those with endometrial thickness less than 7 mm intrauterine injection of platlet rich plasma (PRP) for enhancing endometrial thickness and receptivity
- Primary Outcome Measures
Name Time Method endometrial thickness in mm 72 hours using transvaginal ultrasound to measure endometrial thickness in mm
- Secondary Outcome Measures
Name Time Method clinical pregnancy rate 4 weeks after embryo transfer using transvaginal ultrasound to detect fetal cardiac activity
Trial Locations
- Locations (1)
Rasha
🇪🇬Cairo, Al Qahirah, Egypt