Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock
Phase 3
Completed
- Conditions
- Coagulation Dysfunction in Septic ShockHemodynamic Improvement Induced by Hydrocortisone
- Interventions
- Registration Number
- NCT02114710
- Lead Sponsor
- Nanjing PLA General Hospital
- Brief Summary
The purpose of this study is to find out whether stress doses of hydrocortisone attenuate coagulation dysfunction in patients with septic shock. And discuss the probable mechanism by which little doses of hydrocortisone influence coagulation system in sepsis.
- Detailed Description
Patients were randomized to receive either low-dose hydrocortisone or matching placebo.Severity of coagulopathy was estimated using ISTH DIC score. We determined the complications and mortality in two groups, and analyzed the relationship between hydrocortisone and coagulopathy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 240
Inclusion Criteria
- All patients(age≧18y)
- Admitted for septic shock were considered eligible if they had no life-threatening systemic disease (ASA groups 1~3)
Exclusion Criteria
- Lactation
- Mental disorders
- Disseminated cancer
- Secondary cancers
- Inflammatory bowel disease, or diseases hindering epidural analgesia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Hydrocortisone Hydrocortisone little doses of hydrocortisone
- Primary Outcome Measures
Name Time Method death 30 days after inclusion
- Secondary Outcome Measures
Name Time Method clinical perioperative complications 30 days after inclusion clinical complications 30 days after inclusion MODS SOFA score