Initiation of Hydrocortisone for the Treatment of Septic Shock
- Registration Number
- NCT02580240
- Lead Sponsor
- Northern Jiangsu People's Hospital
- Brief Summary
The purpose of this study : 1）to determine whether hydrocortisone is effective in the treatment of septic shock and 2) to identify the role of timing of low dose hydrocortisone administration in septic shock patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 118
Inclusion Criteria
- age 18 years old or older;
- onset of septic shock within 6 h
Exclusion Criteria
- Systemic corticosteroid therapy within the last 3 months before septic shock;
- high-dose steroid therapy;
- immunosuppression;
- refusal of the attending staff or patient family.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo saline Vials containing normal saline as placebo were identical to those containing hydrocortisone. Placebo administration procedures were similar. hydrocortisone Hydrocortisone Hydrocortisone was administered 200 mg/d as a continuous infusion for 6d, then tapered off. Once all vasopressors were discontinued, the taper protocol was initiated (half dose for three days, then quarter dose for three days and then stopped).
- Primary Outcome Measures
Name Time Method 28-day Mortality 28 days Death from any cause at 28 days after the onset of septic shock
- Secondary Outcome Measures
Name Time Method All Cause Mortality 90 days Death from any cause at 90 days after the onset of septic shock
Trial Locations
- Locations (1)
Northern Jiangsu Province people's hospital
🇨🇳Yangzhou, Jiangsu, China