Effect of daily vitamin C supplementation with or without flavonoid supplements on periodontal and systemic conditions before and after periodontal treatment - Quercetin Supplements in Initial Periodontal Treatment (QSIPT)

niversiteit van Amsterdam0 个研究点目标入组 81 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

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•- age: >=18 years;
•- proximal bone loss of > 3mm in 2 non-adjacent teeth,
•- probing pocket depth > 3 mm and bleeding on probing on at least 25% of their total sites and documented radiographic bone loss,
•- good general health.

•- diagnosis of any acute periodontal problem which requires immediate treatment;
•- use of antibiotics within the previous 6 months;
•- pregnant or lactating women;
•- previous initial periodontal treatment within the last year;
•- current orthodontic treatment;
•- use of any medication which may interfere with quercetin, or with the study outcomes.*
•- current daily use of supplements containing vitamin C
•- patients who have had immunotherapy (<3 months before appointment) or who need treatment for malignancy
•- patients who have been irradiated in head and neck area
•- patients in whom the immune response has been compromised (eg Papillon Lefèvre syndrome)
•- patients who are unable to provide oral hygiene themselves (physically or mentally handicapped)
•- patients with a jaw resection done
•- patients with Sjögren's syndrome
•* Antibiotics (incl. Prophylaxis) and regular use (more than once a week) of anti-inflammatory drugs, steroidal anti-inflammatory drugs (NSAIDs, namely Ibuprofen, Diclofenac, Acetylsalicylic acid, Naproxen) and non-steroidal anti-inflammatory drugs (corticosteroids).

发起方

niversiteit van Amsterdam