Effect of Noninvasive Ventilation in Thoracic-abdominal Kinematics of Individuals With Heart Failure Associated With Cardiomegaly: a Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Universidade Federal de Pernambuco
- Enrollment
- 24
- Locations
- 1
- Primary Endpoint
- Thoraco-abdominal kinematics
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Introduction: Noninvasive ventilation (NIV) has been used to minimize such impairment and increasing ventilator reserve in individuals with heart failure. Aim: To analyze thoracoabdominal kinematics (TK) in individuals with HF associated to cardiomegaly after using NIV. Methods: A randomized crossover clinical trial with allocation consisted of two experimental phases: NIV and control, 7 days apart of each other. During NIV phase, 30 minutes of bi-level ventilation was performed. Any type of ventilator support was offered during control phase. Optoeletronic plethismography was performed to asses TK.
Investigators
Daniella Cunha Brandao
PhD
Universidade Federal de Pernambuco
Eligibility Criteria
Inclusion Criteria
- •body mass index (BMI) \<30 kg/m2
- •functional class II-III according to the New York Heart Association
- •of the echocardiogram últiimos 6 months showing ejection fraction (LVEF) ≤ 45%,
- •últiimos echocardiogram of six months showing cardiac hypertrophy (left Ventricular Diastolic Diameter (LVDD)\> 55mm, Diameter Systolic left Ventricular (LVSD)\> 45mm ),
- •(optimized from the point of view of drug,
- •clinical stability.
Exclusion Criteria
- •unstable angina, myocardial infarction or heart surgery three months before the beginning of the research,
- •chronic orthopedic, infectious or metabolic diseases,
- •FEV1/FVC \<70% predicted characterizing obstructive respiratory disorder;
- •active smokers;
- •Limitation on the use of NIV: claustrophobia, inability to remain with their mouths closed, abdominal distention, hemodynamic instability, heart rate (HR) \<60 bpm, recent trauma, nausea and vomiting face.
Outcomes
Primary Outcomes
Thoraco-abdominal kinematics
Time Frame: Seven days
The thoraco-abdominal kinematics was performed by optoelectronic plethysmography which were evaluated as primary outcomes: volume change of rib cage (Δv CT), variables related to volume change of rib cage by hemithorax (ΔV ht CT): tidal volume of cash left thoracic (CT VC sx) and tidal volume right ribcage (VC CT dx); variables with distribution volume in different compartments: tidal volume on pulmonary rib cage (VC CTP), tidal volume in abdominal rib cage (VC CTA ) and tidal volume in the abdomen (AB VC).
Secondary Outcomes
- Other ventilatory responses(Seven days)