The development of diabetes-associated macrovascular disease in humanized mice - Humanized mice for studying diabetes-associated cardiovascular disease

niversitair Medisch Centrum Groningen0 个研究点目标入组 128 人开始时间: 待定最近更新: 2024年5月6日

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•Patients eligible for participation are diagnosed with T2DM (duration 10-15 yrs) and divided into diabetic patients with CAD or without cardiovascular disease. Patients eligible for participation in the various control groups are patients without a history of T2DM but with CAD, respectively. In addition, healthy individuals who have neither a history of diabetes, cardiovascular disease, inflammatory or autoimmune disease, nor obesity nor any other chronic disease are will be included. Definition of CAD: Coronary artery disease (CAD) CAD is defined as previous myocardial infarction, resting ECG indicative of past MI, positive ECG at exercise stress test, echocardiography stress-test positive for inducible ischemia, evidence of significant coronary artery stenose on angiography with or without typical chest pain. Participants allocated to the different groups will be matched for: - gender - age - smoking - BMI - arterial hypertension - HbA1c (diabetics) - lipid profile

•Predefined exclusion criteria for T2DM include diagnosis of T1DM and presence of any of the following (self-reported) medical conditions: - auto-immune diseases - acute or chonic infection - age >80yrs - hemodialysis - immunosuppression - any other unrelated disease. Exclusion criteria for non-diabetics include: - diagnosis of T1DM or T2DM - auto-immune diseases - acute or chonic infection - age >80yrs - hemodialysis - immunosuppression - any other unrelated disease .

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