NL-OMON36433
Completed
Not Applicable
The development of diabetes-associated macrovascular disease in humanized mice - Humanized mice for studying diabetes-associated cardiovascular disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 128
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients eligible for participation are diagnosed with T2DM (duration 10\-15 yrs) and divided into diabetic patients with CAD or without cardiovascular disease. Patients eligible for participation in the various control groups are patients without a history of T2DM but with CAD, respectively. In addition, healthy individuals who have neither a history of diabetes, cardiovascular disease, inflammatory or autoimmune disease, nor obesity nor any other chronic disease are will be included. Definition of CAD: Coronary artery disease (CAD) CAD is defined as previous myocardial infarction, resting ECG indicative of past MI, positive ECG at exercise stress test, echocardiography stress\-test positive for inducible ischemia, evidence of significant coronary artery stenose on angiography with or without typical chest pain. Participants allocated to the different groups will be matched for: \- gender \- age \- smoking \- BMI \- arterial hypertension \- HbA1c (diabetics) \- lipid profile
Exclusion Criteria
- •Predefined exclusion criteria for T2DM include diagnosis of T1DM and presence of any of the following (self\-reported) medical conditions: \- auto\-immune diseases \- acute or chonic infection \- age \>80yrs \- hemodialysis \- immunosuppression \- any other unrelated disease. Exclusion criteria for non\-diabetics include: \- diagnosis of T1DM or T2DM \- auto\-immune diseases \- acute or chonic infection \- age \>80yrs \- hemodialysis \- immunosuppression \- any other unrelated disease .
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Phase 4
Multiclinical Study for Diabetic Macrovascular complications(MSDM)JPRN-UMIN000006244MSDM900
Completed
Not Applicable
Microvascular complications of diabetes mellitusmicrovascular complications in patients with diabetes type 1 and 2E14.3DRKS00007880niversitätsklinikum Heidelberg, Klinik für Endokrinologie, Stoffwechsel und Klinische Chemie502
Not yet recruiting
Not Applicable
Study on complications of diabetes and risk of heart attackCTRI/2019/01/017120Osmania Medical College
Completed
Not Applicable
Is the presence and development of microvascular disease in type 1 diabetes related to changes in brain structure and cognitive function?abnormalities of the small blood vessels inside the brain and the relationship with attentionconcentration and memoryMicrovascular disease of the brain and cognitive functioning1001265310007963NL-OMON29744Vrije Universiteit Medisch Centrum150
Completed
Not Applicable
Is the presence and development of microvascular disease in type 1 diabetes related to changes in brain structure and cognitive function?diabetic encephalopathydiabetic braincomplication100126531004706010014623NL-OMON37971Vrije Universiteit Medisch Centrum159