Exploration of Pupil Dilation in Horner's Patients Taking Flomax
Trial Snapshot
- Phase
- Phase 4
- Status
- Terminated
- Enrollment
- 1
- Locations
- 2
- Primary Endpoint
- Pupil Size Measurements
Study Overview
Brief Summary
This study is evaluating the pupil dilation of Horner's Patients who have ever taken an alpha blocker such as Tamsulosin. Patients will undergo eye dilation as would occur at a yearly eye examination, but their pupil dilation measurements will be recorded.
Detailed Description
This study will enroll 10 participants who have a unilateral Horner's Syndrome AND have a history of taking an alpha blocker such as Tamsulosin. Participants will be recruited based on those two enrollment criteria, and after consenting they will undergo pupil dilation with 10% phenylephrine. Once fully dilated the pupil size will be measured. Pupil dilation size of the eye affected by the Horner's Syndrome will be compared to the eye not affected by Horner's. Primary study outcome is the comparative dilation size of the Horner's affected eye to the non affected eye in all subjects.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Horner's Syndrome
- •History of taking an alpha blocker (tamsulosin/ terazosin/doxazosin/alfuzosin/silodosin) medication
Exclusion Criteria
- •Subjects with untreated hypertension
- •Subjects with thyrotoxicosis
- •Pregnant women
- •Inability to consent
- •Subjects with anatomical narrow angles who have never had a dilated exam
Arms & Interventions
10% phenylephrine
All patients will receive 10% phenylephrine at their eye examination as the drug to dilate the pupil. After pupil dilation, pupil size will be measured.
Intervention: 10% phenylephrine (Drug)
Outcomes
Primary Outcomes
Pupil Size Measurements
Time Frame: 20-30 minutes after 10% phenylephrine has been placed in each eye.
pupil dilation measurements will be taken of each eye at the eye examination.
Secondary Outcomes
No secondary outcomes reported
Investigators
Cristos Ifantides, MD, MBA
Associate Professor, Department of Ophthalmology
Denver Health and Hospital Authority