Retrospective Evaluation of Bone Mineral Density Measurements, Clinical Indications, and Risk Factors for Osteopenia/Osteoporosis in Female Adolescents Attending at a Tertiary Care Center
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Bone Mineral Density (BMD) Z-scores in Adolescent Girls
研究概览
简要总结
This retrospective study evaluates bone mineral density (BMD) measurements obtained by dual-energy X-ray absorptiometry (DEXA) in adolescent girls aged 12 to 21 years at a tertiary care center. The study focuses on patients referred from the adolescent gynecology clinic as well as from other medical specialties.
Key objectives are:
Comparing the BMD indications and results requested from the gynecology department with the indications and BMD results requested from other departments. Thus, the BMD scores of patients with hypogonadism can be compared with other groups at risk for bone health.
To assess BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency, functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
To analyze the relationship between gynecologic clinical features-such as age at menarche and duration of amenorrhea-and BMD Z-scores.
By combining clinical, hormonal, and densitometric data, this study aims to identify risk factors for low bone density in adolescents, support earlier recognition of osteopenia/osteoporosis, and provide guidance for appropriate interventions in adolescent gynecology practice.
详细描述
Adolescence is a critical period for bone mass acquisition, and disturbances during this stage may predispose to osteopenia or osteoporosis in later life. Various clinical conditions encountered in gynecology, endocrinology, and other specialties may require evaluation of bone mineral density (BMD). However, data on referral indications and bone health outcomes in adolescents remain scarce.
This retrospective study focuses on female adolescents aged 12-21 years who underwent dual-energy X-ray absorptiometry (DEXA) scans at a tertiary care center. The cohort includes patients referred from the adolescent gynecology clinic as well as those referred from other medical departments.
The study objectives are:
To compare referral indications for BMD testing between gynecology and other specialties.
To evaluate differences in BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency (POI), functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 12 Years 至 21 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Female adolescents aged 12-21 years
- •Underwent bone mineral density (BMD) measurement with DEXA at the study center between 2020 and 2025
- •Available clinical and biochemical records, including referral indication
排除标准
- •Incomplete or missing BMD scan data
- •Insufficient clinical information in medical records
- •Patients with underlying conditions unrelated to bone health that preclude accurate evaluation (e.g., major skeletal deformities interfering with DEXA interpretation)
结局指标
主要结局
Bone Mineral Density (BMD) Z-scores in Adolescent Girls
时间窗: At the time of DEXA scan (retrospective chart review, 2020-2025
Comparison of BMD Z-scores between adolescents (12-21 years) referred from the adolescent gynecology clinic and those referred from other specialties.
次要结局
未报告次要终点
研究者
Nursen Kurtoglu Aksoy
Obstetrics and Gynecology Specialist, Bagcilar Training and Research Hospital
Bagcilar Training and Research Hospital