Reperfusion of the brain after endovascular thrombectomy for ischemic stroke: development of novel prognostic imaging biomarkers using magnetic resonance imaging
- Conditions
- cerebral infarctionstroke1000796310014523
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
- A clinical diagnosis of acute ischemic stroke
- Age 18 years or older
- Treated with EVT for a large vessel occlusion of the anterior circulation
(intracranial carotid artery or middle cerebral artery (M1 segment or M2
segment) confirmed by neuroimaging (CTA or MRA) resulting in a successful
recanalization (defined as eTICI >= 2B)
- Written informed consent obtained
- Pre-stroke disability which interferes with assessment of functional outcome
at 90 days, i.e. mRS >2
- Contraindication(s) for MRI (e.g. claustrophobia, pacemaker, metallic
implant, known contrast allergy)
- Clinical condition unsuited for MRI imaging or prolonged stay at the
Radiology department (e.g. agitation and restlessness, neurologic deterioration)
- Use of general anesthesia during EVT
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome of this study is the National Institutes of Health Stroke<br /><br>Scale (NIHSS) 24 hours after successful recanalization.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary radiological outcomes at 24 hours after successful recanalization:<br /><br>- infarct volume on DWI/FLAIR<br /><br>- intracerebral haemorrhage according to the Heidelberg Bleeding<br /><br>Classification10 on SWI<br /><br>- recanalization status on MRA<br /><br><br /><br>Secondary clinical outcomes:<br /><br>- Modified Rankin Scale (mRS) score at 90 days (± 14 days)<br /><br>- symptomatic intracranial haemorrhage (defined as haemorrhage detected on<br /><br>brain imaging with >=4 points increase in NIHSS) </p><br>