Erythrocyte and Adipocyte G6PD Activity Levels in Obesity

Completed

• Conditions: Obesity; Diabetes

• Registration Number: NCT01322035
• Lead Sponsor: University of South Alabama

Brief Summary

This study compares the improvement of weight, fasting lipid profile (triglycerides, cholesterol, HDL, and LDL) and diabetes after gastric bypass surgery with an improvement in levels of an enzyme called glucose-6-phosphate dehydrogenase (G6PD).

Detailed Description

Same as brief summary

Study Timeline

• Study Start: 2009-12
• Study First Submitted: 2010-06-23
• Study First Submitted QC: 2011-03-23
• Study First Posted: 2011-03-24
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Results First Submitted: 2017-11-27
• Status Verified: 2024-05
• Results First Submitted QC: 2024-05-07
• Last Update Submitted: 2024-05-07
• Results First Posted: 2024-05-16
• Last Update Posted: 2024-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• Age > 19 years of age and <70 years of age
• HGA1c<6.0%
• fasting blood sugar less than 100mg/dL

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Exclusion Criteria

• Taking antidiabetic medications for other indications

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measure Erythrocyte G6PD Levels in Diabetic vs. Non-diabetic Morbidly Obese Patients Undergoing Laparoscopic Gastric Bypass.	G6PD levels will be measured at the following time intervals: Baseline(prior to gastric bypass surgery), 1 week, 6 weeks, and 12 weeks post surgery.	G6PD levels will be measured various time intervals. G6PD is the rate limiting enzyme of the pentose phosphate pathway that provides NADPH required for lipid synthesis. G6PD overexpression is implicated in insulin resistance, hyperlipidemia and increases in oxidative stress.

Secondary Outcome Measures

Name	Time	Method
Measure Omentum G6PD Levels in Diabetic vs. Non-diabetic Morbidly Obese Patients Undergoing Laparoscopic Gastric Bypass.	time of gastric bypass
Measure Adipocyte G6PD Levels in Diabetic vs. Non-diabetic Morbidly Obese Patients Undergoing Laparoscopic Gastric Bypass.	G6PD levels will be measured at the following time intervals: Baseline(prior to gastric bypass surgery), 1 week, 6 weeks, and 12 weeks post surgery.	G6PD levels will be measured various time intervals. G6PD is the rate limiting enzyme of the pentose phosphate pathway that provides NADPH required for lipid synthesis. G6PD overexpression is implicated in insulin resistance, hyperlipidemia and increases in oxidative stress.
Measure Hepatocyte G6PD Levels in Diabetic vs. Non-diabetic Morbidly Obese Patients Undergoing Laparoscopic Gastric Bypass.	time of gastric bypass

Trial Locations

Locations (2)

Mobile Infirmary Medical Center; 🇺🇸 Mobile, Alabama, United States

University of South Alabama; 🇺🇸 Mobile, Alabama, United States