VLDL-triglyceride Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Very Low Density Lipoprotein-Triglyceride and apoB-100 concentrations
研究概览
简要总结
This study is being conducted to learn more about the role of diet and exercise in regulating plasma triglyceride (fat) metabolism. The investigators will examine the effect of acute (24 hour) changes in energy intake and expenditure on fat metabolism the following day.
详细描述
Excess body fat and a sedentary lifestyle are associated with increased plasma triglyceride (TG) and apolipoprotein B-100 (apoB-100) concentrations, which are important risk factors for the development of cardiovascular disease.
Weight loss and endurance exercise improve plasma lipid and lipoprotein concentrations. However, the mechanisms responsible for this effect are largely unknown, and much uncertainty remains regarding the independent roles of dietary energy intake, exercise energy expenditure, and net energy balance in controlling plasma TG concentrations.
The main goal of this project, therefore, is to investigate the mechanisms by which acute alterations in energy balance, induced by diet and/or physical activity (endurance exercise), regulate very-low density lipoprotein (VLDL) metabolism.
Subjects will be asked to perform 3 separate trials. One of these will always be an "energy balance" trial that will act as the control trial for the other 2 trials they perform. Subjects will therefore be randomized to 2 different study arms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •overweight and obese men
- •normal to mild hypertriglyceridemia
排除标准
- •Any medical condition other than increased body weight (e.g. diabetes, heart disease, etc.).
- •Use of drugs known to affect lipid metabolism (e.g. statins, etc.).
- •Regular exercise training.
研究组 & 干预措施
Negative energy balance
Comparison between isocaloric and hypocaloric diets with no exercise performed in any trials
干预措施: Negative energy balance (Behavioral)
Positive energy balance
Comparison between isocaloric and hypercaloric diets with no exercise performed in any trials
干预措施: Positive energy balance (Behavioral)
Positive energy balance
Comparison between isocaloric and hypercaloric diets with no exercise performed in any trials
干预措施: Energy balance (Behavioral)
Energy balance with exercise
Comparison between an isocaloric diet without exercise and a hypercaloric diet with a sufficient amount of exercise performed to match the excess calories consumed resulting in both trials being in net energy balance.
干预措施: Energy balance with exercise (Behavioral)
Energy balance with exercise
Comparison between an isocaloric diet without exercise and a hypercaloric diet with a sufficient amount of exercise performed to match the excess calories consumed resulting in both trials being in net energy balance.
干预措施: Energy balance (Behavioral)
Negative energy balance
Comparison between isocaloric and hypocaloric diets with no exercise performed in any trials
干预措施: Energy balance (Behavioral)
Negative energy balance with exercise
Comparison between consuming an isocaloric diet without exercise and consuming the same amount of calories as in the isocaloric trial but with exercise performed resulting in net negative energy balance in the exercise trial.
干预措施: Negative energy balance with exercise (Behavioral)
Negative energy balance with exercise
Comparison between consuming an isocaloric diet without exercise and consuming the same amount of calories as in the isocaloric trial but with exercise performed resulting in net negative energy balance in the exercise trial.
干预措施: Energy balance (Behavioral)
结局指标
主要结局
Very Low Density Lipoprotein-Triglyceride and apoB-100 concentrations
时间窗: After acute (24 hour) changes in energy intake and/or energy expenditure
次要结局
- Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 secretion rates(After acute (24 hour) changes in energy intake and/or energy expenditure)
- Plasma free fatty acid concentration and turnover rate(After acute (24 hour) changes in energy intake and/or energy expenditure)
- Plasma insulin concentration(During acute (24 hour) changes in energy intake and/or energy expenditure)
- Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 clearance rates from plasma(After acute (24 hour) changes in energy intake and/or energy expenditure)
- Plasma glucose concentration and turnover rate(After acute (24 hour) changes in energy intake and/or energy expenditure)
- Plasma glucose concentration(During acute (24 hour) changes in energy intake and/or energy expenditure)
- Plasma free fatty acid concentration(During acute (24 hour) changes in energy intake and/or energy expenditure)