Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
- Conditions
- Cardiovascular Diseases
- Registration Number
- NCT00830999
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
This study is being conducted to learn more about the role of diet and exercise in regulating plasma triglyceride (fat) metabolism. The investigators will examine the effect of acute (24 hour) changes in energy intake and expenditure on fat metabolism the following day.
- Detailed Description
Excess body fat and a sedentary lifestyle are associated with increased plasma triglyceride (TG) and apolipoprotein B-100 (apoB-100) concentrations, which are important risk factors for the development of cardiovascular disease.
Weight loss and endurance exercise improve plasma lipid and lipoprotein concentrations. However, the mechanisms responsible for this effect are largely unknown, and much uncertainty remains regarding the independent roles of dietary energy intake, exercise energy expenditure, and net energy balance in controlling plasma TG concentrations.
The main goal of this project, therefore, is to investigate the mechanisms by which acute alterations in energy balance, induced by diet and/or physical activity (endurance exercise), regulate very-low density lipoprotein (VLDL) metabolism.
Subjects will be asked to perform 3 separate trials. One of these will always be an "energy balance" trial that will act as the control trial for the other 2 trials they perform. Subjects will therefore be randomized to 2 different study arms.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
- overweight and obese men
- normal to mild hypertriglyceridemia
- Smoking
- Any medical condition other than increased body weight (e.g. diabetes, heart disease, etc.).
- Use of drugs known to affect lipid metabolism (e.g. statins, etc.).
- Regular exercise training.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Very Low Density Lipoprotein-Triglyceride and apoB-100 concentrations After acute (24 hour) changes in energy intake and/or energy expenditure
- Secondary Outcome Measures
Name Time Method Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 secretion rates After acute (24 hour) changes in energy intake and/or energy expenditure Plasma insulin concentration During acute (24 hour) changes in energy intake and/or energy expenditure Measured hourly over the 24 h period.
Plasma free fatty acid concentration and turnover rate After acute (24 hour) changes in energy intake and/or energy expenditure Liver Very Low Density Lipoprotein-Triglyceride and apoB-100 clearance rates from plasma After acute (24 hour) changes in energy intake and/or energy expenditure Plasma glucose concentration and turnover rate After acute (24 hour) changes in energy intake and/or energy expenditure Plasma glucose concentration During acute (24 hour) changes in energy intake and/or energy expenditure Measured hourly over the 24 h period.
Plasma free fatty acid concentration During acute (24 hour) changes in energy intake and/or energy expenditure Measured hourly over the 24 h period.
Trial Locations
- Locations (1)
Washington University in Saint Louis
🇺🇸Saint Louis, Missouri, United States
Washington University in Saint Louis🇺🇸Saint Louis, Missouri, United States