The impact of neuromuscular relaxation and nociception guided anaesthesia on hemodynamic variables during abdominal laparoscopic surgery: a strategy trial.

Phase 4

Recruiting

• Conditions: anesthesie, laparoscopie; anesthesia

• Registration Number: NL-OMON52953
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

ASA 1-3
Age > 18
Scheduled for laparoscopic or robotic abdominal surgery
Ability to give oral and written consent

Exclusion Criteria

Known or suspected neuromuscular disorders impairing neuromuscular function;
Allergies to muscle relaxants, anesthetics or narcotics;
A (family) history of malignant hyperthermia;
Women who are or may be pregnant;
Preexisting cardiac disease (any);
Untreated or uncontrolled hypertension;
COPD gold 3 or higher
Any contradictions for TEE:
Preexistent esophageal pathology (stricture, tumor, diverticulum)
Any increased risk factor for upper gastro intestinal tract bleed:
History of GI surgery;
History of GI bleed;
Esophageal varices;
Gastric or esophageal inflammation;
Severe thrombocytopenia (less than 50k) or severely elevated INR (>4).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Mean arterial pressure at 30 minutes after installation of the pneumoperitoneum</p><br>

Secondary Outcome Measures

Name	Time	Method
<p> Mean arterial pressure at all other time points<br /><br>Left ventricular ejection fraction, stroke volume, systolic and diastolic<br /><br>function, afterload and cardiac output<br /><br>Stroke volume variation<br /><br>Systemic vascular resistance<br /><br>Haemodynamic instability score </p><br>