Feasibility Trial of the Modified Atkins Diet and Bevacizumab for Recurrent Glioblastoma

Early Phase 1

Completed

• Conditions: Glioblastoma; Brain Tumor
• Interventions: Drug: Bevacizumab; Behavioral: Modified Atkins Diet

• Registration Number: NCT02768389
• Lead Sponsor: Case Comprehensive Cancer Center

Brief Summary

Patients may participate in this research study if they have glioblastoma. (a brain tumor) that has come back after being treated. Standard treatment for this cancer is a chemotherapy drug called bevacizumab. This research study involves bevacizumab in combination with a special diet called the Modified Atkins Diet (MAD).

The purpose of this study is to research if patients can stay on the MAD when it is added to the standard bevacizumab treatment.

Detailed Description

Primary Objective

- Determine compliance to treatment at 6 and 12 weeks. Compliance is assessed by review of the daily food diary and the urine and serum ketone levels. Diet compliance is defined as following the diet guidelines 80% of the time with resultant ketosis 80% of the time. If 60% of the patients are compliant with the diet, as defined above, that is a considered a positive result.

Secondary Objective(s)

* Determine patient compliance in monitoring of blood glucose and urine levels of ketosis.

* Determine obstacles to compliance.

* Determine the frequency of achieving ketosis, as measured by urine ketones checked daily and serum BHB checked every two weeks.

* Determine quality of life (FACT-BR) and adverse events.

* Determine response, progression free survival at 6 months (PFS 6), and overall survival (OS).

Exploratory Objective

* To correlate levels of ketosis and blood sugar with treatment outcome.

* To correlate the level of MCT4 expression and IDH1 mutation status with treatment outcome.

Study Timeline

• Study First Submitted: 2016-05-09
• Study First Submitted QC: 2016-05-10
• Study First Posted: 2016-05-11
• Study Start: 2016-09-06
• Primary Completion: 2018-11
• Study Completion: 2018-11
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-14
• Last Update Posted: 2019-03-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Patients must have histologically or cytologically confirmed glioblastoma or other grade IV malignant glioma (i.e. gliosarcoma, small cell glioblastoma, etc.), recurrent after prior external beam fractionated radiotherapy and temozolomide chemotherapy.

• Any number of prior recurrences are allowed

• Karnofsky Performance status ≥60

• Patients must have normal organ and marrow function as defined below:

  • Hemoglobin ≥ 9.0 g/dl

  • Absolute neutrophil count ≥ 1.5 x 10^9/L

  • Platelet count ≥ 100 x 10^9/L

  • Total bilirubin ≤ 1.5 X institutional upper limit of normal

  • Aspartate aminotransferase (AST) (SGOT) ≤ 3.0x institutional upper limit of normal

  • Alanine aminotransferase (ALT) (SGPT) ≤ 3.0x institutional upper limit of normal

  • Serum Creatinine ≤ 1.5 X institutional upper limit of normal

    • Cr <2, blood urea nitrogen (BUN) < 100mg/dL

  • Blood coagulation parameters: international normalized ratio (INR) ≤ 1.5

• Minimum interval since last drug therapy;

  • 3 weeks since last non-cytotoxic therapy
  • 3 weeks must have elapsed since the completion of non-nitrosourea-containing chemotherapy regimen.
  • 6 weeks since the completion of a non-nitrosourea-containing therapy regimen.

• Patients must have no concurrent malignancy except curatively treated basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix and breast, adequately treatment stage I or II cancer from which the patient is in complete remission. Patients with other malignancies must also be disease free for at least three years.

• Patients must be maintained on a stable corticosteroid regimen from the time of their baseline scan until the start of the treatment and/or for at least 5 days before starting treatment.

• Patients with the potential for pregnancy or impregnating their partners must agree to follow acceptable birth control methods to avoid conception. The effects of bevacizumab on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (double barrier method of birth control or abstinence prior to study entry, for the duration of study participation and after completing treatment. Should a woman become pregnant or suspect that she is pregnant while she or her partner is participating in this study, she should inform the treating physician immediately.

• Subjects must have the ability to understand and the willingness to sign a written informed consent document.

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Exclusion Criteria

• Patients who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
• Patients who are receiving any other investigational agents.
• History of allergic reactions attributed to compounds of similar chemical or biologic composition to bevacizumab.
• Patients who have had previous treatment with bevacizumab.
• Patients with uncontrolled intercurrent illness including, but not limited to ongoing or active infection, active bowel instruction, diabetic (insulin dependent), Active or remote pancreatitis, Pancreatic insufficiency, symptomatic congestive heart failure (NYHA > 2), unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Pregnant or breastfeeding women are excluded from this study because bevacizumab is an agent with the potential for teratogenic or abortifacient effects. Because there is an unknown, but potential risk for adverse events in nursing infants secondary to treatment of the mother with bevacizumab, breastfeeding should be discontinued if the mother is treated with bevacizumab. These potential risks may also apply to other agents used in this study.
• Known diagnosis of human immunodeficiency virus (HIV). (HIV testing is not required).
• Patients who have undergone major surgery (ie, intra-thoracic, intra abdominal or inra-pelvic), open biopsy or significant traumatic injury =< 4 weeks prior to starting study drug, or patients who have had minor procedures, percutaneous biopsies or placement of vascular access device ≤ 1 week prior to starting study drug, or who have not recovered from side effects of previous procedure or injury.
• Patients with cirrhosis, or active viral or nonviral hepatitis.
• Implanted pacemaker, defibrillator, deep brain stimulator, or other implanted electronic devices in the brain or other documented clinically significant arrhythmias.
• Evidence of increased intracranial pressure (clinically significant papilledema, vomiting, and nausea, or reduced level of consciousness).
• Patients who are unwilling to comply with protocol.
• Myocardial infarction within the last 6 months.
• Symptomatic atrial fibrillation.
• Patients with a body mass index (BMI) >35, < 20.
• Patients with a genetic disorder of fat metabolism.
• Patients who are allergic to milk.
• Insulin dependent diabetes mellitus.
• Patients with uncontrolled hypertension. Patients with a history of hypertension must be well controlled (<160/90) on a regimen of hypertensive medication.
• Patients with known inborn errors of metabolism of primary carnitine deficiency, carnitine palmitoyltransferase I or II deficiency, carnitine translocase deficiency, beta-oxidation defects, pyruvate carboxylase deficiency and porphyria.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Modified Atkins Diet and Bevacizumab	Modified Atkins Diet	Patients and caregivers will be educated by a nutritionist skilled in the MAD. Patients will also be receiving Bevacizumab as standard of care.
Modified Atkins Diet and Bevacizumab	Bevacizumab	Patients and caregivers will be educated by a nutritionist skilled in the MAD. Patients will also be receiving Bevacizumab as standard of care.

Primary Outcome Measures

Name	Time	Method
Number of subjects with ketosis	Up to 12 weeks	The number of patients with documented ketosis (Serum beta-hydroxybutyrate (BHB) above 4mg/L) for at least 80% of the time as a measure of feasibility
Number of subjects following Modified Atkins Diet	Up to 12 weeks	The number of patients following a Modified Atkins Diet for at least 80% of the time as a measure of feasibility

Secondary Outcome Measures

Name	Time	Method
Correlation of blood sugar levels by tumor response	Up to 12 weeks	Correlate the relationship between blood sugar levels and measured level of tumor response as a measure of treatment outcomes
Correlation of ketosis values by compliance level	Up to 12 weeks	Correlate the relationship between ketosis values and measured level of compliance
Correlation of blood sugar levels by compliance level	Up to 12 weeks	Correlate the relationship between blood sugar levels and measured level of compliance
Correlation of ketosis values by tumor response	Up to 12 weeks	Correlate the relationship between ketosis values and measured level of tumor response as a measure of treatment outcomes

Trial Locations

Locations (4)

OhioHealth Research and Innovation Institute; 🇺🇸 Columbus, Ohio, United States

Cleveland Clinic Taussig Cancer Institute, Case Comprehensive cancer Center; 🇺🇸 Cleveland, Ohio, United States

University Hospitals Cleveland Medical Center, Seidman Cancer Center, Case Comprehensive Cancer Center; 🇺🇸 Cleveland, Ohio, United States

University of Cincinnati; 🇺🇸 Cincinnati, Ohio, United States