Latent Tuberculosis in Second Generation Immigrants From High Risk Countries Compare to Low-risk Young Israeli Adults

Not Applicable

Completed

• Conditions: Latent Tuberculosis
• Interventions: Procedure: Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)

• Registration Number: NCT02073669
• Lead Sponsor: Sheba Medical Center

Brief Summary

The aim of study is to evaluate the prevalence of latent TB in second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000) compare to the control native Israelis without a family member who was born in a country with high incidence of tuberculosis. Using study questionnaire IGRA and tuberculin skin test the investigators expect that the second generation immigrants group will have more positive IGRA test than the control native group.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2014-02-25
• Study First Submitted QC: 2014-02-26
• Study First Posted: 2014-02-27
• Study Start: 2014-03
• Primary Completion: 2018-08
• Study Completion: 2018-11
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-24
• Last Update Posted: 2019-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• Age 18-25
• Men and women
• Second generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000).
• Native Israelis without a family member who was born in a country with high incidence of tuberculosis.

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Exclusion Criteria

• Prior contact with a tuberculosis patient
• Working (more than a month) in high risk setting such as health care workers, working with immigrants from countries with high incidence of tuberculosis.
• HIV infection and any immunodeficiency condition.
• Recent live-virus vaccination
• Acute infectious disease
• Prior serious reaction to tuberculin skin test
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Native Israelis	Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)	Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA).
Second generation immigrants from high TB incidence countries	Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA)	Answering the study Questionnaire and blood sampling for Interferon gamma release assay (IGRA).

Primary Outcome Measures

Name	Time	Method
Interferon gamma release assay ( IGRA)	Up to 3 months after tuberculin skin test

Trial Locations

Locations (2)

Sheba Medical Center; 🇮🇱 Ramat Gan, Israel

Israeli Defense Forces; 🇮🇱 Ramat-Gan, Israel