Early laser treatment for burn scars

Not Applicable

Completed

Conditions: Prevention/treatment of hypertrophic scars in burn patients
Skin and Connective Tissue Diseases

Registration Number: ISRCTN14392301

Lead Sponsor: Salisbury NHS Foundation Trust

Brief Summary: 2022 Protocol article in https://pubmed.ncbi.nlm.nih.gov/35392303/ (added 04/08/2022)

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 153

Inclusion Criteria

1. NHS patients, with burn injuries >1% Total Body Surface Area (TBSA), are eligible if they have had skin grafts to,
or have conservatively managed, burn wounds or donor sites that:
1.1. Have delayed healing of greater than 2 weeks.
1.2. Have potential for Hypertrophic Scarring (HS).
1.3 Are suitable for scar management therapy.
2. The scar is within 3 months of healing, where healing time-point is defined during wound management. The combination of excessive redness with increased thickness and/or hardness provides clear indication of HS.
3. Children aged 16 - 18 are able to participate with appropriate consent.

Exclusion Criteria

1. Unable to give informed consent.
2. Below 16 years of age.
3. Prone to keloid scarring.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient-rated Patient Observer Scar Assessment Scale (POSAS) at baseline and 6 months

Secondary Outcome Measures

Name	Time	Method
Measured at baseline and 6 months<br>1. QoL: Bristol CARe scale.<br>2. Quality Adjusted Life Years (QALY): SF-12 Health Survey.<br>3. Scar colour: Colorimeter measurements of redness (DSMIII ColorMeter, Cortex Technology, Denmark). Objective measurement is compared to POSAS colour score.<br>4. MCID - A 7-point scale question evaluates improvement at 6 month follow-up, as judged by the participant.