PET study of brain tau deposition in traumatic brain injury using [11C]PBB3

Not Applicable

• Conditions: Healthy volunteer, Traumatic brain injury (TBI)

• Registration Number: JPRN-UMIN000013517
• Lead Sponsor: ational Institute of Radiological Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-04-01
• Study Completion: 2018-12-31
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

Not provided

Exclusion Criteria

I. Patients 1. Subjects without ability to make informed consent 2. Subjects with any psychiatric disorder not due to TBI 3. Subjects with any organic brain disorder not due to TBI 4. Subjects with severe physical complication 5. Subjects with severe claustrophobia 6. Pregnant women 7. Subjects with tattoo 8. Subjects with metallic medical device in the body 9. Subjects who was considered to be inappropriate to participate in the study II. Healthy volunteers 1. Subjects without ability to make informed consent 2. Subjects with any psychiatric disorder 3. Subjects with any organic brain disorder 4. Subjects with severe physical complication 5. Subjects with severe claustrophobia 6. Subjects who has participated in other study in recent 6 months. 7. Pregnant women 8. Subjects with tattoo 9. Subjects with metallic medical device in the body 10. Subjects who was considered to be inappropriate to participate in the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Distribution volume and binding potential measured by positron emission tomography with [11C]PBB3

Secondary Outcome Measures

Name	Time	Method
Difference of spatial distribution of [11C]PBB3 and [11C]PIB Correlations between tau deposition and various clinical scales