Cognitive Impairments in Psychotic Disorders

Recruiting

• Conditions: Psychotic Disorders; Cognitive Impairment
• Interventions: Diagnostic Test: DAPAR Tests (IQ equivalent test)

• Registration Number: NCT05597579
• Lead Sponsor: Sheba Medical Center

Brief Summary

Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break

Detailed Description

In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.

Study Timeline

• Study Start: 2020-02-12
• Study First Submitted: 2022-02-24
• Status Verified: 2022-10
• Study First Submitted QC: 2022-10-27
• Last Update Submitted: 2022-10-27
• Study First Posted: 2022-10-28
• Last Update Posted: 2022-10-28
• Primary Completion: 2023-05-01
• Study Completion: 2024-05-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study Group	DAPAR Tests (IQ equivalent test)	Patients diagnosed with psychotic disorder.
Control Group	DAPAR Tests (IQ equivalent test)	Healthy Controls

Primary Outcome Measures

Name	Time	Method
Changes in DAPAR (An Israeli cognitive test) scores	1 day (During recruitment visit)	Cognitive changes in both groups (lowest 10 - highest 90)

Secondary Outcome Measures

Name	Time	Method
Social Functioning	1 day (During recruitment visit)	PSP (Personal and Social Performance Scale) Scores (lowest 0- highest 100)
Psychotic Symptoms	1 day (During recruitment visit)	PANSS-6 (Positive and Negative Syndrome Scale - Abbrevieted) scores (lowest 0- highest 36)
Coping strategies	1 day (During recruitment visit)	COPE (Assessing Coping Strategies) scores (lowest 0 - highest 90)
Cognitive Functioning	1 day (During recruitment visit)	WAIS-III (Wechsler Adult Intelligence Scale) (4 specific sub-tests)

Trial Locations

Locations (1)

Sheba Medical Center; 🇮🇱 Ramat-Gan, Israel