Immune cell activation following ischemic cerebrovascular events: a multimodal exploratory study

Withdrawn

Conditions: Atherosclerosis
Cerebrovascular disease
10003216

Registration Number: NL-OMON49930

Lead Sponsor: niversitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Withdrawn

Sex: Not specified

Target Recruitment: 10

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
- Age >18 years
- Stroke or TIA with signs or ischemia on imaging compatible with the
neurological deficit.
- Scheduled for carotid endarterectomy based on current clinical standards

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
- Severe disability (stay in nursing home).
- Auto-immune or auto-inflammatory disease
- Current use of immunomodulating drugs
- Recent infection with fever >38.5 C < 1 month ago.
- Pregnancy
- Renal insufficiency (MDRD <30 ml/min)
- Allergy for FDG or components thereof
- Breastfeeding

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Markers of macrophage proliferation and activation in the explanted carotid<br /><br>plaque.<br /><br>2. Markers of proliferation of the HSPCs and the composition and phenotype of<br /><br>the HSPCs in the bone marrow aspirate<br /><br>3. Number and phenotype of circulating myeloid cells.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. 18F-FDG uptake in the culprit carotid artery (ie the carotid artery that<br /><br>corresponds with the neurological symptoms of the TIA or stroke and will be<br /><br>operated) and the other large arteries (including aorta, carotid arteries,<br /><br>iliac arteries)<br /><br>2. 18F-FDG uptake in the bone marrow</p><br>