The Immune Response to Stroke

Recruiting

• Conditions: Dementia; Stroke, Acute
• Interventions: Other: Analysis of post-stroke immune responses

• Registration Number: NCT05277129
• Lead Sponsor: University of Oslo

Brief Summary

Some patients develop cognitive decline after a stroke, but we don't always understand the mechanisms. It has been proposed that a proportion of the patients develop an autoimmune immune response, and that this could potentially explain the cognitive decline in some of the patients. The current study aims to investigate this hypothesis in a subgroup of patients with stroke.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-24
• Status Verified: 2022-03
• Study First Submitted: 2022-03-03
• Study First Submitted QC: 2022-03-03
• Last Update Submitted: 2022-03-03
• Study First Posted: 2022-03-14
• Last Update Posted: 2022-03-14
• Primary Completion: 2025-12-31
• Study Completion: 2029-06-06

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Stroke < 72 h
• Age > 18 years

Exclusion Criteria

• Brain hemorrhage verified by CT or MRI scan
• Previous or present immunological disease or other serious comorbidity
• Ongoing immune respons after infection or vaccination < 1 month
• Cognitive without ability to understand and/or give an informed consent to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Stroke patients	Analysis of post-stroke immune responses	-

Primary Outcome Measures

Name	Time	Method
The B cell and T cell response in peripheral blood	1 day (subject inclusion)

Trial Locations

Locations (1)

Akershus University Hospital; 🇳🇴 Lørenskog, Norway