EUCTR2008-004431-38-GB进行中（未招募）1 期
ACE inhibition and mechanisms of skeletal muscle weakness in COPD
Imperial College0 个研究点目标入组 80 人开始时间: 2010年11月24日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Adult, consenting patient with COPD diagnosed according to GOLD criteria.
- •Quadriceps weakness defined as a force in Kg<120% of body mass index.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Clinically unstable patients (within one month of exacerbation), those with a permanent pacemaker (which is a contraindication to magnetic stimulation), or significant co-morbidity, patients with an accepted indication for ACE inhibition (left ventricular dysfunction, diabetes) or a contraindication such as renovascular disease; creatinine clearance (estimated) <50); hypotension; use of anticoagulants (contra-indication to biopsy) or ACE-I or ATII receptor antagonists.
- •Allergy to ACE-inhibitors.
- •Patients will not be enrolled within three months of participation in a pulmonary rehabilitation program.
研究者
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