Prevention of skeletal muscle and myocardial free-fatty acid induced microvascular dysfunction in skeletal muscle and myocardium by exercise
Completed
- Conditions
- ill bloodvesselsmicrovascular dysfunction100285931001842410047066
- Registration Number
- NL-OMON43964
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 38
Inclusion Criteria
Young healthy male subjects. Age 18-30 years.
Exclusion Criteria
A drastic recent change in physical activity (eg. just stopped being an athlete), conditions that can significantly influence the amount of energy that is needed for physical activity (eg. a lower-leg prothesis), history of obesity, hypertension, diabetes mellitus, hyperlipidemia, smoking (currently, or > 1 package per month over the last 2 years), documented cardiovascular disease, use of medication that could potentially affect insulin sensitivity or microvascular function or inflammatory status.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The effect of FFA on insulin-induced changes in microvascular blood volume of<br /><br>skeletal muscle and myocardium will be correlated with amount of physical<br /><br>activity as measured with accelerometers and VO2max.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secundary endpoints will be microvascular blood volume during basal and<br /><br>hyperinsulinemic state without Intralipid infusion, in myocardium and skeletal<br /><br>muscle. Also, whole-body insulin sensitivity as measured by the glucose<br /><br>infusion rate will be correlated with physical activity. Body fat percentage<br /><br>and blood pressure (Nexfin) will be measured to test if these parameters are<br /><br>equal between subjects and if not in which amount they differ. Contraction<br /><br>induced microvascular recruitment will be measured with the handgrip<br /><br>dynamometer to test if we can show an increase of MBV with Ceus during a<br /><br>different physiological parameter than insulin alone.</p><br>