A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
- Conditions
- Crohn's Disease
- Interventions
- Registration Number
- NCT05242471
- Lead Sponsor
- Janssen Research & Development, LLC
- Brief Summary
The purpose of this study is to evaluate the efficacy of JNJ-78934804 at Week 48 compared to guselkumab and golimumab.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 703
- Diagnosis of Crohn's disease (CD) for at least 3 months prior to baseline
- Confirmed diagnosis of moderate to severe CD as assessed by Crohn'
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group 6: JNJ-78934804 (Low-dose) JNJ-78934804 Participants will receive JNJ-78934804 dose regimen 3 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 1: Placebo Placebo Participants will receive placebo subcutaneously (SC). All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 4: JNJ-78934804 (High-dose) JNJ-78934804 Participants will receive JNJ-78934804 dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 5: JNJ-78934804 (Mid-dose) JNJ-78934804 Participants will receive JNJ-78934804 dose regimen 2 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 2: Guselkumab Guselkumab Participants will receive guselkumab dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension. Group 3: Golimumab Golimumab Participants will receive golimumab dose regimen 1 SC. All participants who meet inadequate response criteria will be escalated to an active treatment. Participants who are eligible and willing to continue the study intervention that they are receiving at Week 44 may enter the long-term extension.
- Primary Outcome Measures
Name Time Method Percentage of Participants with Clinical Remission at Week 48 Week 48 Percentage of participants with clinical remission at Week 48 will be reported. Clinical remission is based on the Crohn's Disease Activity Index (CDAI).
Percentage of Participants with Endoscopic Response at Week 48 Week 48 Percentage of participants with endoscopic response at Week 48 will be reported. Endoscopic response is based on change from baseline in the simple endoscopic score for Crohn's disease (SES-CD), as assessed by central endoscopy reading.
- Secondary Outcome Measures
Name Time Method Percentage of Participants with Patient-reported Outcomes (PRO)-2 Remission at Week 48 Week 48 Percentage of participants with PRO-2 remission at Week 48 will be reported. PRO-2 remission is based on the average daily abdominal pain (AP) and stool frequency (SF) scores.
Percentage of Participants with Endoscopic Remission at Week 48 Week 48 Percentage of participants with endoscopic remission at Week 48 will be reported. Endoscopic remission is based on the SES-CD, as assessed by central endoscopy reading.
Percentage of Participants with Corticosteroid-Free Clinical Remission at Week 48 Week 48 Percentage of participants with corticosteroid-free (60-day) clinical remission at Week 48 will be reported.
Secondary Comparison: Percentage of Participants with Clinical Remission at Week 48 Week 48 Percentage of participants with clinical remission at Week 48 will be reported. Clinical remission is based on the Crohn's Disease Activity Index (CDAI).
Secondary Comparison: Percentage of Participants with Endoscopic Response at Week 48 Week 48 Percentage of participants with endoscopic response at Week 48 will be reported. Endoscopic response is based on change from baseline in the SES-CD, as assessed by central endoscopy reading.
Percentage of Participants with Adverse Events (AEs) Up to Week 48 An AE is any untoward medical occurrence in a clinical study participant administered a pharmaceutical (investigational or non-investigational) product. An AE does not necessarily have a causal relationship with the intervention.
Percentage of Participants with Serious Adverse Events (SAEs) Up to Week 48 A SAE is any untoward medical occurrence that at any dose: results in death; is life-threatening; requires inpatient hospitalization or prolongation of existing hospitalization; results in persistent or significant disability/incapacity; is a congenital anomaly/birth defect; is a suspected transmission of any infectious agent via a medicinal product; is medically important.
Clinical Laboratory Parameters Over Time Up to Week 48 Clinical laboratory parameters over time will be reported.
Vital Sign Parameters Over Time Up to Week 48 Vital sign parameters over time will be reported.
Suicidal Ideation Assessment Using Columbia Suicide Severity Rating Scale (C-SSRS) Score Up to Week 48 The C-SSRS scale consists of 28 items in 4 sections: suicide behavior, actual attempts, suicidal ideation, and intensity of ideation. Worsening of suicidal ideation is defined as an increase in severity of suicidal ideation from baseline.
Serum Concentrations of Guselkumab Over Time Up to Week 48 Serum concentrations of guselkumab over time will be reported. Serum samples will be analyzed to determine concentrations of guselkumab using a validated, specific, and sensitive method.
Serum Concentrations of Golimumab Over Time Up to Week 48 Serum concentrations of golimumab over time will be reported. Serum samples will be analyzed to determine concentrations of golimumab using a validated, specific, and sensitive method.
Percentage of Participants with Antibodies to Guselkumab Up to Week 48 Percentage of participants with antibodies to guselkumab will be reported.
Titers of Antibodies to Guselkumab Up to Week 48 Titers of antibodies to guselkumab will be reported.
Percentage of Participants with Antibodies to Golimumab Up to Week 48 Percentage of participants with antibodies to golimumab will be reported.
Titers of Antibodies to Golimumab Up to Week 48 Titers of antibodies to golimumab will be reported.
Percentage of Participants with Neutralizing Antibodies to Guselkumab. Up to Week 48 Percentage of participants with neutralizing antibodies to guselkumab will be reported.
Percentage of Participants with Neutralizing Antibodies to Golimumab Up to Week 48 Percentage of participants with neutralizing antibodies to golimumab will be reported.
Trial Locations
- Locations (450)
Universitatsklinikum Schleswig Holstein Kiel
🇩🇪Kiel, Germany
Evangelisches Krankenhaus Kalk
🇩🇪Köln, Germany
Eugastro GmbH
🇩🇪Leipzig, Germany
Staedtisches Klinikum Lueneburg
🇩🇪Lueneburg, Germany
Medizinische Fakultät Mannheim der Universität Heidelberg
🇩🇪Mannheim, Germany
Gastroenterologische Gemeinschaftspraxis Minden
🇩🇪Minden, Germany
Klinikum der Universitaet Muenchen
🇩🇪Munich, Germany
Universitatsklinikum Munster
🇩🇪Munster, Germany
MVZ Portal 10
🇩🇪Münster, Germany
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Tumorzentrum Nordthüringen Medizinisches Versorgungszentrum
🇩🇪Nordhausen, Germany
Medius Klinik Nürtingen
🇩🇪Nürtingen, Germany
Siloah St Trudpert Klinikum
🇩🇪Pforzheim, Germany
Universitaetsklinikum Regensburg
🇩🇪Regensburg, Germany
Universitaetsmedizin Rostock
🇩🇪Rostock, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH
🇩🇪Saarbrücken, Germany
Universitatsklinikum Tubingen
🇩🇪Tübingen, Germany
Universitatsklinikum Ulm
🇩🇪Ulm, Germany
Universitatsklinikum Wurzburg
🇩🇪Würzburg, Germany
General Hospital of Athens 'Ippokrateion'
🇬🇷Athens, Greece
Sotiria General State Hospital of Chest Diseases
🇬🇷Athens, Greece
Hippokration Hospital
🇬🇷Thessaloniki, Greece
Obudai Egeszsegugyi Centrum Kft
🇭🇺Budapest, Hungary
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Semmelweis Egyetem I.Belgyogyaszati Klinika
🇭🇺Budapest, Hungary
Bugat Pal Korhaz
🇭🇺Gyongyos, Hungary
Szegedi Tudomanyegyetem
🇭🇺Szeged, Hungary
Markusovszky Egyetemi Oktatokorhaz
🇭🇺Szombathely, Hungary
ICON Hospital Orchid Medi services and Research Private Limited
🇮🇳Ahmedabad, India
M S Ramaiah Medical College and Hospital
🇮🇳Bengaluru, India
Siksha O Anusandhan University - Institute of Medical Scienc
🇮🇳Bhubaneswar, India
Srm Institutes For Medical Science (Sims)
🇮🇳Chennai, India
Fortis Memorial Research Institute
🇮🇳Gurugram, India
Asian Institute Of Gastroenterology
🇮🇳Hyderabad, India
Yashoda Super Speciality Hospitals
🇮🇳Secunderabad, India
P D Hinduja National Hospital and Medical Research Center
🇮🇳Mumbai, India
All India Institute of Medical Sciences
🇮🇳New Delhi, India
Surat Institute of Digestive Sciences Hospitals
🇮🇳Surat, India
Gujarat Gastro and Vascular Hospital
🇮🇳Surat, India
Haemek Medical Center - Afula
🇮🇱Afula, Israel
Centrum Zdrowia Matki Dziecka i Mlodziezy
🇵🇱Warszawa, Poland
Centralny Szpital Kliniczny Mswia
🇵🇱Warszawa, Poland
Centre Hospitalier Lyon Sud
🇫🇷Pierre-Bénite, France
CHRU Hopital de Pontchaillou
🇫🇷Rennes, France
Hôpital Yves Le Foll
🇫🇷Saint-Brieuc, France
Centre hospitalier universitaire de St Etienne
🇫🇷Saint-Etienne, France
CHU Rangueil
🇫🇷Toulouse, France
CHRU Nancy Brabois
🇫🇷Vandoeuvre les Nancy, France
Reumatika-Centrum Reumatologii, NZOZ
🇵🇱Warszawa, Poland
NZOZ Vivamed
🇵🇱Warszawa, Poland
Bodyclinic Sp. z o.o. sp. k
🇵🇱Warszawa, Poland
Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. Szpital Specjalistyczny Barska
🇵🇱Wloclawek, Poland
Melita Medical Sp. z o.o.
🇵🇱Wroclaw, Poland
China Medical University Hospital
🇨🇳Taichung, Taiwan
National Cheng Kung University Hospital
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Royal Victoria Hospital
🇬🇧Belfast, United Kingdom
Centrum Medyczne Oporow
🇵🇱Wroclaw, Poland
ETG Zamosc
🇵🇱Zamosc, Poland
Centro Hospitalar Lisboa Norte EPE Hosp. Santa Maria
🇵🇹Lisboa, Portugal
Hospital de Portimao-Centro Hospitalar do Barlavento Algarvio
🇵🇹Portimao, Portugal
Centro Hospitalar Vila Nova de Gaia
🇵🇹Porto, Portugal
Centro Hospitalar de Entre o Douro e Vouga, E.P.E
🇵🇹Santa Maria da Feira, Portugal
Singapore General Hospital
🇸🇬Singapore, Singapore
KL Ling Gastroenterology and Liver Clinic
🇸🇬Singapore, Singapore
Gi Associates Gastroenterology
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore
Splosna bolnisnica Celje
🇸🇮Celje, Slovenia
Univerzitetni klinicni center Ljubljana
🇸🇮Ljubljana, Slovenia
Worthwhile Clinical Trials Lakeview Hospital
🇿🇦Benoni, South Africa
Mediclinic Panorama
🇿🇦Cape Town, South Africa
Inspired GI Care
🇿🇦Cape Town, South Africa
Clinical Research Centre University of Cape Town
🇿🇦Cape Town, South Africa
Groote Schur Hospital
🇿🇦Cape Town, South Africa
Hillcrest private
🇿🇦Durban, South Africa
Hosp. Univ. La Paz
🇪🇸Madrid, Spain
Hosp. de Navarra
🇪🇸Pamplona, Spain
Hosp. Montecelo
🇪🇸Pontevedra, Spain
Corporacio Sanitari Parc Tauli
🇪🇸Sabadell, Spain
Hosp. Univ. Marques de Valdecilla
🇪🇸Santander, Spain
Hosp. Univ. de Torrejon
🇪🇸Torrejón de Ardoz, Spain
Universitetssjukhuset Orebro
🇸🇪Orebro, Sweden
Karolinska University Hospital
🇸🇪Solna, Sweden
Ersta sjukhus
🇸🇪Stockholm, Sweden
Universitatsspital Basel
🇨🇭Basel, Switzerland
Inselspital Universitatsspital Bern
🇨🇭Bern, Switzerland
Gastroenterologische Spezialpraxis - Berlin-Karlshorst
🇩🇪Berlin-Karlshorst, Germany
Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital
🇯🇵Sapporo, Japan
Sapporo Medical University Hospital
🇯🇵Sapporo, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Japan
Tohoku University Hospital
🇯🇵Sendai, Japan
Tokyo Metropolitan Bokutoh Hospital
🇯🇵Sumida ku, Japan
Chang-Hua Christian Hospital
🇨🇳Changhua, Taiwan
Box Hill Hospital
🇦🇺Box Hill, Australia
Monash Health, Monash Medical Centre
🇦🇺Clayton, Australia
Western Health
🇦🇺Footscray, Australia
St Vincent's hospital
🇦🇺Melbourne, Australia
Royal Prince Alfred Hospital
🇦🇺Newtown, Australia
Royal Adelaide Hospital
🇦🇺North Terrace, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Australia
Nepean Hospital
🇦🇺Penrith, Australia
Chronos Clinica Medica Ltda
🇧🇷Brasilia, Brazil
Centro Digestivo de Curitiba - Instituto de Pesquisa Clínica
🇧🇷Curitiba, Brazil
Centro de Estudos Clínicos do Interior Paulista - CECIP
🇧🇷Jau, Brazil
Liga Norte Riograndense Contra O Cancer
🇧🇷Natal, Brazil
Hopital Saint Louis - Service de Gastro-Entérologie, 1 Avenue Claude Vellefaux
🇫🇷Paris, France
West China Hospital Sichuan University
🇨🇳Chengdu, China
Chongqing Medical University
🇨🇳Chongqing, China
The First People's Hospital of Foshan
🇨🇳Foshan, China
Sun Yat-sen University - The Sixth Affiliated Hospital Guangdong Gastrointestinal Hospital
🇨🇳Guangzhou, China
Guangzhou First Municipal People's Hospital
🇨🇳Guangzhou, China
Nanfang Hospital of Southern Medical Hospital
🇨🇳Guangzhou, China
Hainan General Hospital
🇨🇳Haikou, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Jinhua municipal central hospital
🇨🇳Jinhua, China
The First Affiliated Hospital of NanChang University
🇨🇳Nanchang, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, China
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Shanghai East Hospital
🇨🇳Shanghai, China
Ruijin Hospital Shanghai Jiao Tong University
🇨🇳Shanghai, China
The Central Hospital of Wuhan
🇨🇳Wuhan, China
Wuhan Union Hospital
🇨🇳Wuhan, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, China
Wuxi People s Hospital
🇨🇳Wuxi, China
Zhongshan Hospital, Xiamen University
🇨🇳Xiamen, China
Yangzhou First People's Hospital
🇨🇳Yangzhou, China
ZhuZhou Central Hospital
🇨🇳ZhuZhou, China
Opca bolnica Bjelovar
🇭🇷Bjelovar, Croatia
University Hospital Center Split
🇭🇷Split, Croatia
University Hospital Dubrava
🇭🇷Zagreb, Croatia
Vojenska nemocnice Brno
🇨🇿Brno, Czechia
ISCARE a.s.
🇨🇿Praha 9, Czechia
Detska klinika Masarykovy nemocnice v Usti nad Labem
🇨🇿Usti nad Labem, Czechia
Aarhus University Hospital
🇩🇰Aarhus, Denmark
Bispebjerg Og Frederiksberg Hospital
🇩🇰Copenhagen, Denmark
Herlev Hospital, University of Copenhagen
🇩🇰Herlev, Denmark
Odense Universitetshospital
🇩🇰Odense, Denmark
Silkeborg Hospital
🇩🇰Silkeborg, Denmark
West Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Tallinn Children's Hospital
🇪🇪Tallinn, Estonia
Tartu University Hospital
🇪🇪Tartu, Estonia
CHU Amiens - Hopital Sud
🇫🇷AMIENS cedex 1, France
CHRU De Besancon
🇫🇷Besancon, France
Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor
🇫🇷Créteil, France
CHU Grenoble
🇫🇷Grenoble, France
Hopital Nord Marseille
🇫🇷Marseille, France
CHU de Nantes hotel Dieu
🇫🇷Nantes, France
Clinique Ambroise Pare
🇫🇷Neuilly-sur-Seine, France
CHU de Nice Hopital de l Archet
🇫🇷Nice, France
Gastroenterologische Praxis Balsiger und Seibold
🇨🇭Bern, Switzerland
Kantonsspital St Gallen
🇨🇭St. Gallen, Switzerland
UniversitaetsSpital Zuerich
🇨🇭Zuerich, Switzerland
Hospital Ampang
🇲🇾Ampang, Malaysia
University of Alabama Liver Center
🇺🇸Birmingham, Alabama, United States
Del Sol Research Management, LLC
🇺🇸Tucson, Arizona, United States
Moore Clinical Trials, LLC
🇺🇸Little Rock, Arkansas, United States
Om Research LLC
🇺🇸Apple Valley, California, United States
Valley Gastroenterology Medical Group
🇺🇸Arcadia, California, United States
Southern California Research Center
🇺🇸Coronado, California, United States
Desert Gastroenterology Associates
🇺🇸Lancaster, California, United States
Cedars Sinai Medical Center
🇺🇸Los Angeles, California, United States
UCLA
🇺🇸Los Angeles, California, United States
Hoag Memorial Hospital
🇺🇸Newport Beach, California, United States
UCI Irvine Medical Center
🇺🇸Orange, California, United States
Medical Associates Research Group, Inc.
🇺🇸San Diego, California, United States
University of California San Francisco
🇺🇸San Francisco, California, United States
University of Colorado
🇺🇸Aurora, Colorado, United States
Medical Research Center of Connecticut
🇺🇸Hamden, Connecticut, United States
Yale University School Of Medicine
🇺🇸New Haven, Connecticut, United States
MedStar Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
Pioneer Research Solutions Inc.
🇺🇸Coconut Creek, Florida, United States
Homestead Associates in Research Inc
🇺🇸Homestead, Florida, United States
Osceola Mental Health D/B/A Park Place Behavioral Health Care
🇺🇸Kissimmee, Florida, United States
Florida Research Center Inc.
🇺🇸Lakewood Ranch, Florida, United States
University of Miami Hospital
🇺🇸Miami, Florida, United States
Gastroenterology Group Of Naples
🇺🇸Naples, Florida, United States
Omega Research Consultants
🇺🇸Orlando, Florida, United States
Synergy Clinical Research
🇺🇸Saint Petersburg, Florida, United States
GCP Clinical Research
🇺🇸Tampa, Florida, United States
Atlanta Gastroenterology Associates
🇺🇸Atlanta, Georgia, United States
University of Mississippi Medical Center
🇺🇸Atlanta, Georgia, United States
Gastroenterolgy Associates of Central GA
🇺🇸Macon, Georgia, United States
Gastrointestinal Specialists of Georgia
🇺🇸Marietta, Georgia, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
IU Health University Hospital
🇺🇸Indianapolis, Indiana, United States
Gastroenterology of Southern Indiana
🇺🇸New Albany, Indiana, United States
Cotton O'Neil Digestive Health Center
🇺🇸Topeka, Kansas, United States
Ascension via Christi Research
🇺🇸Wichita, Kansas, United States
Univ. of KS School of Med
🇺🇸Wichita, Kansas, United States
Tri-State Gastroenterology Assoc
🇺🇸Crestview Hills, Kentucky, United States
University of Kentucky
🇺🇸Lexington, Kentucky, United States
Jewish Hospital
🇺🇸Louisville, Kentucky, United States
Gastroenterology Clinic of Acadiana
🇺🇸Lafayette, Louisiana, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Ochsner Medical Center
🇺🇸New Orleans, Louisiana, United States
Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Lahey Hospital & Medical Center
🇺🇸Boston, Massachusetts, United States
Brigham And Women's Hospital
🇺🇸Chestnut Hill, Massachusetts, United States
FC Research, LLC
🇺🇸South Dartmouth, Massachusetts, United States
Detroit Clinical Research Center
🇺🇸Livonia, Michigan, United States
Huron Gastroenterology Associates Center for Digestive Care
🇺🇸Ypsilanti, Michigan, United States
Gastrointestinal Associates LLP
🇺🇸Flowood, Mississippi, United States
Washington University
🇺🇸Saint Louis, Missouri, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
Care Access Las Vegas
🇺🇸Las Vegas, Nevada, United States
Dartmouth Hitchcock
🇺🇸Lebanon, New Hampshire, United States
Northwell Health
🇺🇸Great Neck, New York, United States
A1 Clinical Research
🇺🇸Jackson Heights, New York, United States
Weill Cornell Medical College
🇺🇸New York, New York, United States
Lenox Hill Hospital
🇺🇸New York, New York, United States
Mohawk Valley Endoscopy Center
🇺🇸Utica, New York, United States
University of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
Tryon Medical Group
🇺🇸Charlotte, North Carolina, United States
PMG Research of Winston-Salem
🇺🇸Winston-Salem, North Carolina, United States
University Hospitals Case Medical Center
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Northshore Gastroenterology Research, LLC
🇺🇸Westlake, Ohio, United States
The Oregon Clinic
🇺🇸Portland, Oregon, United States
Susquehanna Gastroenterology Associates
🇺🇸Harrisburg, Pennsylvania, United States
University of Pennsylvania - Perelman School of Medicine
🇺🇸Philadelphia, Pennsylvania, United States
Frontier Clinical Research
🇺🇸Smithfield, Pennsylvania, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Digestive Disease Associates
🇺🇸Rock Hill, South Carolina, United States
Saint Francis Hospital
🇺🇸Germantown, Tennessee, United States
Galen Medical Group
🇺🇸Hixson, Tennessee, United States
Etsu Quillen College Of Medicine
🇺🇸Johnson City, Tennessee, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Amel Med LLC Research
🇺🇸Austin, Texas, United States
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
UT Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Accurate Clinical Research
🇺🇸Houston, Texas, United States
Gastroenterology Clinic Of San Antonio P A
🇺🇸San Antonio, Texas, United States
Texas Digestive Disease Consultants
🇺🇸Southlake, Texas, United States
Digestive Health Specialists
🇺🇸Tacoma, Washington, United States
Care Access Research- Salt Lake City
🇺🇸Salt Lake City, Utah, United States
University of Virginia
🇺🇸Charlottesville, Virginia, United States
Hunter Holmes McGuire Veterans Affairs Medical Center
🇺🇸Richmond, Virginia, United States
Washington Gastroenterology, PLLC
🇺🇸Bellevue, Washington, United States
Swedish Medical Center
🇺🇸Seattle, Washington, United States
University of Washington Digestive Disease Center
🇺🇸Seattle, Washington, United States
Hospital Pulau Pinang
🇲🇾George Town, Malaysia
Marshall Health Clinical Research Center
🇺🇸Huntington, West Virginia, United States
The Queen Elizabeth Hospital
🇦🇺Adelaide, Australia
Mater Hospital Brisbane Inflammatory Bowel Diseases
🇦🇺South Brisbane, Australia
Landeskrankenhaus Salzburg, Universitätsklinik f. Innere Medizin III
🇦🇹Salzburg, Austria
Akh Wien
🇦🇹Wien, Austria
Klinikum Wels Grieskirchen
🇦🇹Wels, Austria
GZA Ziekenhuizen
🇧🇪Antwerpen, Belgium
Algemeen Ziekenhuis Sint-Jan
🇧🇪Brugge, Belgium
Cliniques Universitaires Saint Luc
🇧🇪Bruxelles, Belgium
AZ Maria Middelares
🇧🇪Gent, Belgium
UZ Leuven
🇧🇪Leuven, Belgium
CHU de Liege
🇧🇪Liege, Belgium
CHC MontLegia
🇧🇪Liège, Belgium
Az Sint-Maarten
🇧🇪Mechelen, Belgium
Algemeen Ziekenhuis Delta
🇧🇪Roeselare, Belgium
Vitaz
🇧🇪Sint-Niklaas, Belgium
Hospital Das Clinicas Da Ufmg
🇧🇷Belo Horizonte - MG, Brazil
Fundacao para o Desenvolvimento Medico Hospitalar (UNESP Botucatu)
🇧🇷Botucatu, Brazil
Impar Servicos Hospitalares S/A - Hospital Brasilia
🇧🇷Brasilia, Brazil
Irmandade da Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, Brazil
Associacao Hospitalar Moinhos de Vento
🇧🇷Porto Alegre, Brazil
Hospital das Clinicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
NPCRS Nucleo de Pesquisa Clinica do Rio Grande do Sul
🇧🇷Porto Alegre, Brazil
Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP
🇧🇷Ribeirao Preto, Brazil
Universidade Federal do Rio de Janeiro - Faculdade de Medicina
🇧🇷Rio de Janeiro, Brazil
Pesquisare Saude
🇧🇷Santo Andre, Brazil
Irmandade da Santa Casa da Misericórdia de Santos
🇧🇷Santos, Brazil
CPQuali Pesquisa Clinica LTDA ME
🇧🇷Sao Paulo, Brazil
Hospital Nove de Julho
🇧🇷Sao Paulo, Brazil
Instituto de Assistencia Medica ao Servidor Publico Estadual IAMSPE
🇧🇷Sao Paulo, Brazil
Hepatogastro
🇧🇷Sao Paulo, Brazil
BR Trials
🇧🇷Sao Paulo, Brazil
Kaiser Hospta
🇧🇷São José Do Rio Preto, Brazil
CPCLIN - Centro de Pesquisas Clínicas
🇧🇷São Paulo, Brazil
Instituto D Or de Pesquisa e Ensino IDOR
🇧🇷São Paulo, Brazil
UMHAT 'Aleksandrovska' EAD
🇧🇬Sofia, Bulgaria
MHAT Tzaritza Joanna
🇧🇬Sofia, Bulgaria
Foothills Hospital
🇨🇦Calgary, Alberta, Canada
Gastroenterology and Internal Medicine Research Institute (GIRI)
🇨🇦Edmonton, Alberta, Canada
University of Alberta Hospital
🇨🇦Edmonton, Alberta, Canada
Covenant Health/Grey Nuns hospital
🇨🇦Edmonton, Alberta, Canada
Fraser Clinical Trials Inc.
🇨🇦New Westminster, British Columbia, Canada
The Gordon & Leslie Diamond Health Care Center
🇨🇦Vancouver, British Columbia, Canada
GIRI Gastrointestinal Research Institute
🇨🇦Vancouver, British Columbia, Canada
The Medical Arts Health Research Group
🇨🇦Vancouver, British Columbia, Canada
PerCuro Clinical Research Ltd.
🇨🇦Victoria, British Columbia, Canada
Winnipeg Health Sciences Centre
🇨🇦Winnipeg, Manitoba, Canada
Viable Clinical Research
🇨🇦Bridgewater, Canada
Nova Scotia Health Authority
🇨🇦Halifax, Nova Scotia, Canada
Barrie GI Associates
🇨🇦Barrie, Ontario, Canada
London Health Sciences Centre
🇨🇦London, Ontario, Canada
Toronto Immune and Digestive Health Institute Inc
🇨🇦Toronto, Ontario, Canada
Gastroenterologie Opernstrasse
🇩🇪Kassel, Germany
CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont
🇨🇦Montreal, Quebec, Canada
McGill University - Health Centre - Montreal General Hospital
🇨🇦Montreal, Quebec, Canada
St. Jerome Medical Research
🇨🇦Saint-Jerome, Quebec, Canada
CMIIM, Centre médical L'Enjeu
🇨🇦Ville Mont-Royal, Quebec, Canada
Royal University Hospital
🇨🇦Saskatoon, Saskatchewan, Canada
Hopital Chicoutimi
🇨🇦Saguenay, Canada
China Japan Friendship Hospital
🇨🇳Beijing, China
The second Xiangya Hospital of Central South University
🇨🇳Changsha, China
Changzhou No 2 Peoples Hospital
🇨🇳Changzhou City, China
Charite Universitaetsmedizin Berlin - Campus Charite Mitte
🇩🇪Berlin, Germany
Praxis Für Gastroenteroligie
🇩🇪Berlin, Germany
Charite Campus Benjamin Franklin
🇩🇪Berlin, Germany
Krankenhaus Waldfriede Mitte
🇩🇪Berlin, Germany
Medizinisches Versorgungszentrum (MVZ) Dachau
🇩🇪Dachau, Germany
University Hospital Dresden
🇩🇪Dresden, Germany
MVZ Sanaklinikum Duisburg
🇩🇪Duisburg, Germany
Universitaetsklinik Erlangen
🇩🇪Erlangen, Germany
Universitaetsklinikum Essen
🇩🇪Essen, Germany
Agaplesion Frankfurter Diakonie Kliniken GmbH, Markus Krankenhaus
🇩🇪Frankfurt/Main, Germany
JWG-University Hospital
🇩🇪Frankfurt, Germany
Universitatsklinikum Freiburg
🇩🇪Freiburg, Germany
Klinikum Fulda - Tumorklinik - Germany
🇩🇪Fulda, Germany
Curiositas ad Sanum Studien und Beratungs GmBH
🇩🇪Haag, Germany
Martin-Luther-Universitaet Halle-Wittenberg - Universitaetsk
🇩🇪Halle Saale, Germany
BSF Studiengesellschaft
🇩🇪Halle, Germany
CTC North GmbH & Co. KG, Am Universitätsklinikum Hamburg-Eppendorf
🇩🇪Hamburg, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Gastroenterology Outpatient Clinic Prof. Ehehalt/Dr. Hemstäd
🇩🇪Heidelberg, Germany
University Hospital Heidelberg
🇩🇪Heidelberg, Germany
Universitatsklinikum Jena
🇩🇪Jena, Germany
Praxisgemeinschaft Jerichow
🇩🇪Jerichow, Germany
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Rambam Medical Center
🇮🇱Haifa, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hadassah Hebrew University Medical Center
🇮🇱Jerusalem, Israel
Rabin Med Ctr Beilinson Hosp
🇮🇱Petah Tikva, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
The Chaim Sheba Medical Center
🇮🇱Tel Hashomer, Israel
Assaf Harofeh Medical Center
🇮🇱Tzrifin, Israel
Università degli Studi di Bari
🇮🇹Bari, Italy
A.O. Per L' Emergenza Cannizzaro - U.O. Chirurgia Generale
🇮🇹Catania, Italy
AOU Policlinico G.Martino
🇮🇹Messina, Italy
Ospedale San Raffaele
🇮🇹Milano, Italy
Ospedale Specializzato in Gastroenterologia Saverio de Bellis
🇮🇹Monopoli, Italy
Azienda Ospedaliero Universitaria di Cagliari - Policlinico Duilio Casula di Monserrato
🇮🇹Monserrato, Italy
Azienda Ospedaliera San Gerardo
🇮🇹Monza, Italy
Ospedale Classificato Equiparato Sacro Cuore Don Calabria di Negrar
🇮🇹Negrar ( Ve), Italy
Ospedale Villa Sofia-Cervello
🇮🇹Palermo, Italy
Catholic University of Sacred Hearth
🇮🇹Roma, Italy
IRCCS Humanitas Rozzano-IBD Center Malattie Infiammatorie Croniche Intestinali
🇮🇹Rozzano, Italy
Ospedale Molinette, AO Città della Salute e della Scienza di
🇮🇹Torino, Italy
Asahikawa Medical University Hospital
🇯🇵Asahikawa, Japan
Tokyo Medical and Dental University Hospital
🇯🇵Bunkyo Ku, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Japan
Fukuoka University Hospital
🇯🇵Fukuoka-shi, Japan
Tokai University Hachioji Hospital
🇯🇵Hachioji, Japan
Hamamatsu University Hospital
🇯🇵Hamamatsu, Japan
National Hospital Organization Hirosaki General Medical Center
🇯🇵Hirosaki, Japan
Hirosaki University Hospital
🇯🇵Hirosaki, Japan
Hitachi General Hospital
🇯🇵Hitachi, Japan
Hospital of the University of Occupational and Enviromental Health
🇯🇵Hukuoka, Japan
Hyogo Medical University Hospital
🇯🇵Hyogo, Japan
Kagoshima University Hospital
🇯🇵Kagoshima, Japan
Kagoshima IBD Gastroenterology Clinic
🇯🇵Kagoshima, Japan
Ofuna Chuo Hospital
🇯🇵Kamakura, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Japan
Tsujinaka Hospital Kashiwanoha
🇯🇵Kashiwa, Japan
Saitama Medical University Saitama Medical Center
🇯🇵Kawagoe, Japan
Kyushu Rosai Hospital
🇯🇵Kitakyushu, Japan
Kobe University Hospital
🇯🇵Kobe, Japan
Japanese Red Cross Kumamoto Hospital
🇯🇵Kumamoto, Japan
Kurume University Hospital
🇯🇵Kurume, Japan
University Hospital Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Kyorin University Hospital
🇯🇵Mitaka, Japan
Iwate Medical University Hospital
🇯🇵Morioka, Japan
Nagaoka Red Cross Hospital
🇯🇵Nagaoka, Japan
Nagasaki University Hospital
🇯🇵Nagasaki, Japan
Nagoya University Hospital
🇯🇵Nagoya, Japan
Niigata University Medical And Dental Hospital
🇯🇵Niigata, Japan
Okayama University Hospital
🇯🇵Okayama-shi, Japan
Kinshukai Infusion Clinic
🇯🇵Osaka, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
Japan Community Health Care Organization Osaka Hospital
🇯🇵Osaka, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu, Japan
Saga University Hospital
🇯🇵Saga-shi, Japan
Tokitokai Tokito Clinic Coloproctology Center
🇯🇵Saitama, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Japan
Sapporo Tokushukai Hospital
🇯🇵Sapporo, Japan
Dokkyo Medical University Hospital
🇯🇵Shimotsuga-gun, Japan
Jichi Medical University Hospital
🇯🇵Shimotsuke, Japan
Center Hospital of the National Center for Global Health and Medicine
🇯🇵Shinjuku ku, Japan
Tokyo Women's Medical University Hospital
🇯🇵Shinjuku-Ku, Japan
Takamatsu Red Cross Hospital
🇯🇵Takamatsu, Japan
The Jikei University Hospital
🇯🇵Tokyo, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Tokyo, Japan
Toyama Prefectural Central Hospital
🇯🇵Toyama, Japan
Ieda Hospital
🇯🇵Toyota, Japan
Mie University Hospital
🇯🇵Tsu, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Japan
Jordan University Hospital
🇯🇴Amman, Jordan
Abdali Hospital
🇯🇴Amman, Jordan
Irbid Specialty Hospital
🇯🇴Irbid, Jordan
King Abdullah University Hospital
🇯🇴Irbid, Jordan
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Kosin University Gospel Hospital
🇰🇷Busan, Korea, Republic of
Kyungpook National University Hospital
🇰🇷Daegu, Korea, Republic of
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Dongguk University Ilsan Hospital
🇰🇷Goyang-si, Korea, Republic of
Chosun university hospital
🇰🇷Gwangju, Korea, Republic of
Hallym University Dongtan Sacred Heart Hospital
🇰🇷Hwaseong-si, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea Seoul St.Mary's Hospital
🇰🇷Seoul, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea
🇰🇷Suwon-si, Korea, Republic of
Ajou University Hospital
🇰🇷Suwon, Korea, Republic of
Hospital Sultanah Bahiyah
🇲🇾Alor Setar, Malaysia
Academisch Medisch Centrum Universiteit van Amsterdam
🇳🇱Amsterdam, Netherlands
Albert Schweitzer Ziekenhuis
🇳🇱Dordrecht, Netherlands
Leiden University Medical Center
🇳🇱Leiden, Netherlands
Maastricht Universitair Medisch Centrum
🇳🇱Maastricht, Netherlands
Erasmus MC
🇳🇱Rotterdam, Netherlands
UMC Utrecht
🇳🇱Utrecht, Netherlands
Dunedin Hospital
🇳🇿Dunedin, New Zealand
Hutt Hospital
🇳🇿Lower Hutt, New Zealand
Wellington Hospital
🇳🇿Wellington, New Zealand
Alesund sjukehus
🇳🇴Alesund, Norway
Vestre Viken HF Baerum Sykehus
🇳🇴Gjettum, Norway
Akershus Universitetssykehus
🇳🇴Lørenskog, Norway
Oslo University Hospital HF Ulleval sykehus
🇳🇴Oslo, Norway
Universitetssykehuset Nord-Norge HF
🇳🇴Tromso, Norway
Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Centrum Medyczne Plejady
🇵🇱Krakow, Poland
Centrum Medyczne Promed
🇵🇱Krakow, Poland
AmiCare Centrum Medyczne
🇵🇱Lodz, Poland
Gastromed ZOZ
🇵🇱Lublin, Poland
Wojewodzki Szpital Specjalistyczny w Olsztynie
🇵🇱Olsztyn, Poland
Synexus Polska Sp z o o
🇵🇱Poznan, Poland
Twoja Przychodnia
🇵🇱Poznan, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
Endoskopia Sp z o.o.
🇵🇱Sopot, Poland
Sonomed Sp. z o.o.
🇵🇱Szczecin, Poland
GASTROMED Sp. z o.o.
🇵🇱Torun, Poland
University Hospitals Birmingham NHS Foundation Trust
🇬🇧Birmingham, United Kingdom
Addenbrooke's Hospital
🇬🇧Cambridge, United Kingdom
Glasgow Royal Infirmary
🇬🇧Glasgow, United Kingdom
Queen Elizabeth University Hospital
🇬🇧Glasgow, United Kingdom
Velocity Clinical Research
🇬🇧High Wycombe, United Kingdom
Whipps Cross University Hospital
🇬🇧London, United Kingdom
St George's Healthcare NHS Trust
🇬🇧London, United Kingdom
John Radcliffe Hospital
🇬🇧Oxford, United Kingdom
New Cross Hospital
🇬🇧Wolverhampton., United Kingdom