Effect of Selenium Deficiency on Thyroid Function
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- between-group difference in serum selenium
研究概览
简要总结
As one of the essential micronutrients, selenium has important biological functions. However, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. Previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( T4) to triiodothyronine (T3). A case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated T4 or T4/T3, which may provide more clues for establishing effective selenium assesment methods.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •with normal free triiodothyronine( FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH).
- •without thyroid hormone replacement therapy
- •without medical history of thyroid surgery
- •without iodine radiotherapy;
排除标准
- •acute critical illness in the latest 1 year;
- •weight fluctuation by more than 5% in the latest 3 months;
- •eating disorders
- •neuropsychological disorders
- •allergy to corn or yeast
- •fail to give informed consents.
结局指标
主要结局
between-group difference in serum selenium
时间窗: up to 24 weeks
comparison of the mean serum selenium between the two groups
次要结局
- between-group difference in serum deiodinase activity(up to 24 weeks)
- between-group difference in erythrocyte glutathione peroxidase activity(up to 24 weeks)
研究者
Liuyanping
Dietitian
Peking Union Medical College Hospital