Research on Association Between Selenium Deficiencies and Change of Thyroid Function
- Conditions
- Selenium Deficiency
- Registration Number
- NCT03448588
- Lead Sponsor
- Peking Union Medical College Hospital
- Brief Summary
As one of the essential micronutrients, selenium has important biological functions. However, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. Previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( T4) to triiodothyronine (T3). A case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated T4 or T4/T3, which may provide more clues for establishing effective selenium assesment methods.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- with normal free triiodothyronine( FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH).
- without thyroid hormone replacement therapy
- without medical history of thyroid surgery
- without iodine radiotherapy;
- acute critical illness in the latest 1 year;
- weight fluctuation by more than 5% in the latest 3 months;
- eating disorders
- neuropsychological disorders
- allergy to corn or yeast
- fail to give informed consents.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method between-group difference in serum selenium up to 24 weeks comparison of the mean serum selenium between the two groups
- Secondary Outcome Measures
Name Time Method between-group difference in serum deiodinase activity up to 24 weeks comparison of the mean deiodinase activity between the two groups
between-group difference in erythrocyte glutathione peroxidase activity up to 24 weeks comparison of the mean erythrocyte glutathione peroxidase activity between the two groups
Trial Locations
- Locations (1)
Peking Union Medical College Hospital
🇨🇳Beijing, Beijing, China
Peking Union Medical College Hospital🇨🇳Beijing, Beijing, Chinayanping liu, masterContact861069159081liuyp1227@vip.sina.com