Effect of angiotensin receptor blockers for neointimal coverage after stent implantation.
- Conditions
- Hypertensive patients with coronary arteries disease.
- Registration Number
- JPRN-UMIN000007634
- Lead Sponsor
- Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 70
Not provided
(1) Patients who had cerebral accident in the past 12 weeks (2) Patients with acute ST-segment elevation myocardial infarction (3) Old myocardial infarction. (4) Heart failure (LVEF < 45%) (5) Active myocarditis (6) Active pericardium flame (7) A cardiac transplantation(<=6months) (8) Diabetes mellitus (9) Proteinuria (10)Chronic renal dysfunction (eGFR<=60mL/min/1.73 m2) (11) patient who has a bad prognosis's disease from angina (12) Restenosis (13)Chronic total coronary artery occlusion (14) The target lesion is located in or supplied by an arterial or venous bypass graft (15) The target lesion is located in left main trunk. (16) Vessel diameter<2mm (17) Systolic blood pressure is under 100 mmHg (18)Serum creatinine>1.8 mg/dl (19) Serum potassium>5.5mEq/L (20) Altered hepatic function (serum aspartate aminotransferase or alanine aminotransferase >= 3-folds of standard value in each institute) (21)Definite or provisional diagnosis of renal artery stenosis (22)Patients who meet contraindication of vasoconstrictor (23) Severe valvular heart disease (24) Women who are pregnant or lactating, or of child bearing potential, or with a desire to be a parent during the study period. (25)A psychiatric disorder and legal disability (26) Drug or alcohol addiction(<=2years) (27) Other patients judged as being inappropriate for the subjects of the study by investigators
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Stents stenosis rate with optical coherence tomography
- Secondary Outcome Measures
Name Time Method Target vessel revascularization, changes in high-sensitivity CRP ,changes in angiotensin 2