Valuation in Depressed Mood, Anhedonia, and Anxiety

Not Applicable

Recruiting

• Conditions: Neurobehavioral Components of Reward and Loss Valuation
• Interventions: Behavioral: cognitive behavioral therapy; Behavioral: valuation without instruction; Behavioral: valuation with instruction

• Registration Number: NCT05384158
• Lead Sponsor: Virginia Polytechnic Institute and State University

Brief Summary

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Detailed Description

This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Study Timeline

• Study Start: 2021-08-01
• Study First Submitted: 2022-05-13
• Study First Submitted QC: 2022-05-17
• Study First Posted: 2022-05-20
• Status Verified: 2023-12
• Last Update Submitted: 2023-12-19
• Last Update Posted: 2023-12-26
• Primary Completion: 2026-07
• Study Completion: 2026-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 252

Inclusion Criteria

• mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

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Exclusion Criteria

• history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cognitive behavioral therapy	cognitive behavioral therapy	cognitive behavioral therapy for depression, anxiety, and/or anhedonia
Valuation without instruction	valuation without instruction	repeat laboratory sessions of a reward/loss learning computer game without specific instructions
Valuation with instruction	valuation with instruction	repeat laboratory sessions of a reward/loss learning computer game with specific instructions

Primary Outcome Measures

Name	Time	Method
change in proportion correct on the 'N-arm bandit learning task'	study entrance to study exit, an average of 12 weeks	change in proportion correct on 'N-arm bandit reinforcement learning task' from study entrance to study exit

Secondary Outcome Measures

Name	Time	Method
change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)	study entrance to exit, an average of 12 weeks	change in anxiety symptoms from study entrance to study exit
change in depression symptoms (Beck Depression Inventory)	study entrance to exit, an average of 12 weeks	change in depression symptoms from study entrance to study exit
change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)	study entrance to exit, an average of 12 weeks	change in anhedonia symptoms from study entrance to study exit

Trial Locations

Locations (1)

Fralin Biomedical Research Institute at Virginia Tech Carilion; 🇺🇸 Roanoke, Virginia, United States