An open-label, unblinded, exploratory study to evaluate the eye movement in Parkinson disease patients - ExSEM-PD

Department of Neurology Juntendo University School of Medicine0 sites20 target enrollmentMay 18, 2021

ConditionsParkinson disease

Overview

Phase: N/A
Intervention: Not specified
Conditions: Parkinson disease
Sponsor: Department of Neurology Juntendo University School of Medicine
Enrollment: 20
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The MDS-UPDRS Part III score of PD motor symptoms, the ON/OFF score of the patient symptom diary, and the L-dopa blood concentration showed similar trends to the blink frequency. Furthermore, by extracting various parameters such as blink duration and confidence from the blink information and applying machine learning, we constructed a model to estimate clinical symptoms at the same point in time from 3 minutes of blink data. UPDRS Part III score in real time.

Registry

who.int

Start Date

May 18, 2021

End Date

March 31, 2022

Last Updated

2 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Department of Neurology Juntendo University School of Medicine

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

•1\.Atypical Parkinsonism syndromes 2\.Dementia or at high risk of it (Mini Mental State Examination (MMSE) score \< \= 20\) 3\.Contraindicated for concomitant medications (L\-DOPA / carbidopa) 4\.Hypersensitivity to concomitant medications (L\-DOPA / carbidopa) and/or their ingredients 5\.Co\-existing psychiatric disease (e.g., depression, bipolar disorder or schizophrenia) and/or clinically significant complications (e.g., cerebrovascular accident, heart disease, chronic respiratory disease, uncontrolled hypertension and diabetes) 6\.History of psychiatric disease (e.g., depression, bipolar disorder or schizophrenia) and/or device\-aided therapies (i.e., GPi pallidotomy, thalamotomy, and deep brain stimulation) 7\.Those who are judged by the principal investigator to be inappropriate as research subjects