Machine Vision Based Machine Rating of MDS-UPDRS III
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Parkinsonian Disorders
- Sponsor
- Ruijin Hospital
- Enrollment
- 871
- Locations
- 8
- Primary Endpoint
- Lin's CCC of machine rating vs gold standard rating
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
The Movement Disorders Society (MDS) Unified Parkinson's Disease Rating Scale (UPDRS) Part III (MDS-UPDRS III) is the primary assessment method for motor symptoms in Parkinson's disease patients. Currently, movement disorder specialists conduct semi-quantitative scoring, which entails limitations such as subjectivity, weak sensitivity, and a limited number of professional physicians. This study, based on machine vision, establishes gold standard labels according to expert scoring. By using machine learning, we develop a machine rating model and compare the model's performance with gold standard rating and general clinical rating to investigate the accuracy of machine vision-based MDS-UPDRS III machine rating.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Meeting the diagnostic criteria for Parkinsonism established by the International Movement Disorder Society: having bradykinesia, and meeting at least one of the two criteria for resting tremor or muscle rigidity
- •20 to 80 years old
- •Good compliance, voluntarily joining the study, and able to sign an informed consent form or have it signed by a legal representative
Exclusion Criteria
- •Significant cognitive impairment (MMSE ≤ 23)
- •Unable to sign written informed consent or unable to complete the trial due to other reasons
- •Other situations in which the researcher deems the participant unsuitable for this study
- •Participation in other clinical trials
Outcomes
Primary Outcomes
Lin's CCC of machine rating vs gold standard rating
Time Frame: 1 day
The Lin's Concordance Correlation Coefficient when machine rating equals gold standard rating.
ACC0 of machine rating vs gold standard rating
Time Frame: 1 day
The accuracy rate when machine rating equals gold standard rating.
ACC1 of machine rating vs gold standard rating
Time Frame: 1 day
The accuracy rate when machine rating equals the range of gold standard rating plus or minus one.
Weighted kappa of machine rating vs gold standard rating
Time Frame: 1 day
The weighted kappa when machine rating equals gold standard rating.
Secondary Outcomes
- Accuracy rate of machine rating vs general clinical rating(1 day)
- Accuracy rate of machine facilitated rating vs general clinical rating(1 day)