Prevalence of Toxoplasma Gondii and Toxocara Canis Among Patients With Uveitis

Completed

• Conditions: Uveitis

• Registration Number: NCT01837056
• Lead Sponsor: National Institute of Health, Korea

Brief Summary

Investigate the prevalence of Toxoplasma gondii and Toxocara canis in Uveitis

* serum antibody to T. gondii and T. canis

* PCR with peripheral blood for T. gondii and T. canis

* PCR with aqueous humor for T. gondii and T. canis

* Clinical manifestation of patient with uveitis

Detailed Description

Consecutive patients with uveitis are enrolled in Nune Eye Hospital.

Serum ELISA

* IgM,IgG antibody to Toxoplasma gondii

* IgG antibody to Toxocara canis

PCR

* PCR with serum and aqueous humor to Toxoplasma gondii

* PCR with serum and aqueous humor to Toxocara canis Clinical characteristics

* visual acuity

* intraocular pressure (IOP)

* location and degree of inflammation

* other fundus findings were recorded

questionnaire

* environment, occupation

* pet ownership, exposure to animal

* history of eating raw liver of animal, raw beef or any other raw flesh of animal.

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2012-02
• Study Completion: 2012-02
• Status Verified: 2013-04
• Study First Submitted: 2013-04-12
• Study First Submitted QC: 2013-04-17
• Last Update Submitted: 2013-04-17
• Study First Posted: 2013-04-22
• Last Update Posted: 2013-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• patients with uveitis

Exclusion Criteria

• Patients with history of major ophthalmic surgery within 6 months
• antiviral, antifungal or antiparasitic therapy within 6 months

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients with positive result for serum antibody to Toxoplasma gondii and Toxocara canis	at baseline	proportion of patients with seropositive for Toxoplasma gondii and Toxocara canis among patients

Secondary Outcome Measures

Name	Time	Method
Number of patients with positive PCR with peripheral blood and aqueous humor to Toxoplasma gondii and Toxocara canis	at baseline	Proportion of patient with positive PCR to Toxoplasma gondii and Toxocara canis