Predicting Outcomes of Cardiac Surgery-associated Acute Kidney Injury Using Biomarkers At Initiation of REnal Replacement Therapy (POCKET)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- 28-day mortality
研究概览
简要总结
The aim of this study was to verify the prognostic value of functional kidney biomarkers on survival and renal function recovery in cardiac surgery patients with acute kidney injury.
详细描述
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the second most common type of AKI after septic AKI and is associated with increased mortality and morbidity. Few biomarkers were validated as outcome-specific biomarkers in patients developing AKI after cardiac surgery at initiation of RRT. This study was designed to not only verify the prognostic value of functional kidney biomarkers on survival, but also predict it severity in order to optimize clinical decision making with respect to dialysis initiation and discontinuation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing cardiac surgery who required renal replacement therapy.
排除标准
- •History of End Stage Renal Disease or on Dialysis
- •prior kidney transplantation
- •patients with a DNR order or "do not escalate care" order
结局指标
主要结局
28-day mortality
时间窗: 28 days
Death from any cause at 28 days
Dependence on renal-replacement therapy at 28 days in survivors
时间窗: 28 days
Dependence on renal-replacement therapy was defined as surviving dependent on RRT
次要结局
- Length of stay in the ICU(Up to 90 days or ICU discharge)
- Length of stay in the hospital(Up to 90 days or hospital discharge)
- Adverse events(Up to 90 days)
- the number of days free of renal-replacement therapy, mechanical ventilation at 28 days(28 days)
- 60- and 90-day mortality(Up to 60 or 90 days)