Predicting Outcomes of Cardiac Surgery-associated Acute Kidney Injury Using Biomarkers At Initiation of REnal Replacement Therapy (POCKET)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Shanghai Zhongshan Hospital
- Enrollment
- 1200
- Locations
- 1
- Primary Endpoint
- 28-day mortality
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of this study was to verify the prognostic value of functional kidney biomarkers on survival and renal function recovery in cardiac surgery patients with acute kidney injury.
Detailed Description
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the second most common type of AKI after septic AKI and is associated with increased mortality and morbidity. Few biomarkers were validated as outcome-specific biomarkers in patients developing AKI after cardiac surgery at initiation of RRT. This study was designed to not only verify the prognostic value of functional kidney biomarkers on survival, but also predict it severity in order to optimize clinical decision making with respect to dialysis initiation and discontinuation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing cardiac surgery who required renal replacement therapy.
Exclusion Criteria
- •History of End Stage Renal Disease or on Dialysis
- •prior kidney transplantation
- •patients with a DNR order or "do not escalate care" order
Outcomes
Primary Outcomes
28-day mortality
Time Frame: 28 days
Death from any cause at 28 days
Dependence on renal-replacement therapy at 28 days in survivors
Time Frame: 28 days
Dependence on renal-replacement therapy was defined as surviving dependent on RRT
Secondary Outcomes
- Length of stay in the ICU(Up to 90 days or ICU discharge)
- Length of stay in the hospital(Up to 90 days or hospital discharge)
- Adverse events(Up to 90 days)
- the number of days free of renal-replacement therapy, mechanical ventilation at 28 days(28 days)
- 60- and 90-day mortality(Up to 60 or 90 days)