Etrasimod Versus Placebo as Induction Therapy in Moderately to Severely Active Ulcerative Colitis
- Registration Number
- NCT03996369
- Lead Sponsor
- Arena Pharmaceuticals
- Brief Summary
The purpose of this study is to assess the efficacy of etrasimod on clinical remission in participants with moderately to severely active ulcerative colitis (UC).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 354
- Diagnosed with ulcerative colitis (UC) ≥ 3 months prior to screening
- Active UC confirmed by endoscopy
- Severe extensive colitis
- Diagnosis of Crohn's disease (CD) or indeterminate colitis or the presence or history of a fistula consistent with CD
- Diagnosis of microscopic colitis, ischemic colitis, or infectious colitis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - Etrasimod 2 mg Etrasimod -
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving Clinical Remission Week 12 Clinical remission was based on the modified Mayo score (MMS). The MMS is a composite score of 3 assessments consisting of participant-reported symptoms using daily electronic (e)-diary and centrally read endoscopy: stool frequency (SF), rectal bleeding (RB) and endoscopic score (ES). Clinical remission was defined as SF sub-score = 0 (or = 1 with a greater than or equal to \[\>=\] 1-point decrease from Baseline), RB sub-score = 0, and ES less than or equal to (\<=) 1 (excluding friability). Each component sub-score ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Symptomatic Remission Week 12 Symptomatic remission was defined as an SF sub-score = 0 (or = 1 with a \>= 1 point decrease from Baseline) and RB sub-score = 0. The SF sub-score ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB sub-score ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). Higher scores indicated more severe disease.
Percentage of Participants Achieving Endoscopic Normalization Week 12 Endoscopic normalization was defined as an ES = 0. The ES ranged from 0 to 3 (where 0= normal/inactive disease and 3= severe disease); higher score indicated more severe disease.
Percentage of Participants Achieving Endoscopic Improvement Week 12 Endoscopic improvement was defined as an ES \<= 1 (excluding friability). The ES ranged from 0 to 3 (where 0 = normal/inactive disease and 3 = severe disease); higher score indicated more severe disease.
Percentage of Participants Achieving Clinical Response Week 12 Clinical response was based on the MMS which is a composite score of 3 assessments: SF, RB and ES. Clinical response was defined as a \>= 2-point and \>= 30 percent (%) decrease from Baseline MMS, and a \>= 1-point decrease from Baseline in RB sub-score or an absolute RB sub-score \<= 1. Each component sub-score ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving Symptomatic Response Weeks 2, 4, 8 and 12 Symptomatic response was defined as a \>= 30% decrease from Baseline in composite RB and SF score. The SF sub-score ranged from 0 to 3 (where 0= normal number of stools and 3= at least 5 stools more than normal) and RB sub-score ranged from 0 to 3 (where 0= no blood and 3= blood alone passes). The composite RB and SF score range was from 0 to 6, with higher scores indicating more severe disease.
Percentage of Participants Achieving Complete Symptomatic Remission Weeks 2, 4, 8 and 12 Complete symptomatic remission was defined as an SF sub-score = 0 and RB sub-score = 0. The SF sub-score ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB sub-score ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). Higher scores indicated more severe disease.
Percentage of Participants With Mucosal Healing Week 12 Mucosal healing was defined as an ES \<= 1 (excluding friability) with histologic remission measured by a Geboes Index score less than \[\<\] 2.0). The ES ranged from 0 to 3 (where 0 = normal/inactive disease and 3 = severe disease). The Geboes score grading system, was a validated score for evaluating histologic disease activity in UC as follows: grade 0 = structural and architectural changes; grade 1 = chronic inflammatory infiltrate; grade 2 = lamina propria neutrophils and eosinophils; grade 3 = neutrophils in the epithelium; grade 4 = crypt destruction; grade 5 = erosions or ulceration. A higher Geboes score indicated more severe disease.
Percentage of Participants Achieving Non-invasive Clinical Response Weeks 2, 4, 8 and 12 Non-invasive clinical response was defined as a \>= 30% decrease from Baseline in composite RB and SF sub-scores, and a \>= 1 point decrease from Baseline in RB sub-score or RB sub-score \<= 1. The SF subscore ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB sub-score ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). The composite RB and SF score range was from 0 to 6, with higher scores indicating more severe disease.
Percentage of Participants Achieving Symptomatic Remission at Weeks 2, 4 and 8 Weeks 2, 4 and 8 Symptomatic remission was defined as an SF sub-score = 0 (or = 1 with a \>= 1 point decrease from Baseline) and RB sub-score = 0. The SF sub-score ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB sub-score ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). Higher scores indicated more severe disease.
Trial Locations
- Locations (406)
Hospital Sotero del Rio
🇨🇱Santiago, Chile
Midas Multispeciality Hospital Pvt.Ltd.
🇮🇳Nagpur, Maharashtra, India
Nara Medical University Hospital
🇯🇵Kashihara-city, Nara, Japan
Saga University Hospital
🇯🇵Saga-shi, Saga-ken, Japan
Jikei University Hospital
🇯🇵Minato-ku, Tokyo, Japan
Medicome Sp. Zo.O.
🇵🇱Oswiecim, Poland
Korczowski Bartosz, Gabinet Lekarski
🇵🇱Rzeszow, Poland
SOLUMED Centrum Medyczne
🇵🇱Poznan, Poland
Twoja Przychodnia-Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
EMC INSTYTUT MEDYCZNY SA, EuroMediCare Szpital Specjalistyczny z Przychodnia - Dzial Farmacji
🇵🇱Wroclaw, Poland
General Hospital Sremska Mitrovica
🇷🇸Sremska Mitrovica, Serbia
Endomed, S.R.O
🇸🇰Vranov nad Toplou, Presov, Slovakia
Alian S.R.O
🇸🇰Bardejov, Slovakia
KM Management spol. s r.o.
🇸🇰Nitra, Slovakia
BeneDig s.r.o.
🇸🇰Zilina, Slovakia
Accout Center s.r.o.
🇸🇰Sahy, Slovakia
Atlanta Gastroenterology Associates
🇺🇸Atlanta, Georgia, United States
University of Chicago Medical Center
🇺🇸Chicago, Illinois, United States
Virginia Mason
🇺🇸Seattle, Washington, United States
Radboudumc
🇳🇱Nijmegen, Netherlands
Global Life Research Network, LLC
🇺🇸Miami, Florida, United States
ENDOSKOPIA Sp.zo.o
🇵🇱Sopot, Poland
Care Access Research
🇺🇸Poland, Ohio, United States
Centrum Medyczne Oporow
🇵🇱Wroclaw, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Hospital da Senhora da Oliveira Guimarães
🇵🇹Guimarães, Portugal
Enroll SpA
🇨🇱Santiago, Chile
LHSC - University Hospital
🇨🇦London, Ontario, Canada
Hepato Gastroenterologie HK s.r.o.
🇨🇿Hradec Kralove, Czechia
General Hospital Zadar
🇭🇷Zadar, Croatia
Clinical Hospital Sveti Duh
🇭🇷Zagreb, Croatia
University hospital centre Zagreb
🇭🇷Zagreb, Croatia
Fakultni nemocnice u svate Anny v Brne
🇨🇿Brno, Czechia
CHU Lille - Hôpital Claude Huriez
🇫🇷Lille cedex, Nord, France
CHU Clermont Ferrand - Hôpital d'Estaing
🇫🇷Clermont-Ferrand, Puy De Dome, France
JSC Infectious Diseases, AIDS and Clinical Immunology Research Center
🇬🇪Tbilisi, Georgia
Pannonia Maganorvosi Centrum
🇭🇺Budapest, Hungary
Galilee Medical Center
🇮🇱Nahariya, Israel
Azienda Ospedaliero Universitaria Mater Domini
🇮🇹Catanzaro, Italy
Fukushima Medical University Hospital
🇯🇵Fukushima-shi, Fukushima, Japan
Hiroshima City Hiroshima Citizens Hospital
🇯🇵Hiroshima-shi, Hiroshima, Japan
JCHO Tokyo Yamate Medical Center
🇯🇵Shinjuku-ku, Tokyo, Japan
Fukuoka University Hospital
🇯🇵Fukuoka, Japan
The Catholic University of Korea St. Vincent's Hospital
🇰🇷Suwon-si, Gyeonggi-do, Korea, Republic of
Sierra Clinical Research
🇺🇸Las Vegas, Nevada, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
LLC "Gastroenterological centre Expert"
🇷🇺Saint-Petersburg, Russian Federation
FSBI of higher Education "First Saint Petersburg State Medical University n.a. I.P.Pavlov
🇷🇺Saint-Petersburg, Russian Federation
Private Educational Institution of Higher Education "Medical University "REAVIZ"
🇷🇺Samara, Russian Federation
SPb SBIH "City Hospital # 40 of Kurortnyi region"
🇷🇺Sestroretsk, Russian Federation
LLC "Polyclinic of ultrasonography 4D"
🇷🇺Stavropol, Russian Federation
Clinical Center " Dr Dragisa Misovic Dedinje"
🇷🇸Belgrade, Serbia
Fakultna nemocnica Nitra
🇸🇰Nitra, Slovakia
Inselspital, Gaby Saner, Gastroenterologie, Bauchzentrum
🇨🇭Bern, Switzerland
Uludag University Medical Faculty
🇹🇷Beşevler, Yenimahalle/Ankara, Turkey
Whipps Cross University Hospital
🇬🇧London, Greater London, United Kingdom
AZ Sint-Maarten
🇧🇪Mechelen, Belgium
Phramongkutklao Hospital
🇹🇭Ratchathewi, Bangkok, Thailand
Siriraj Hospital
🇹🇭Bangkoknoi, Bangkok, Thailand
Shweta Paliwal/Vipin Kumar Jain
🇮🇳Jaipur, Rajasthan, India
Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar, Verona, Italy
King Chulalongkorn Memorial Hospital
🇹🇭Pathum wan, Bangkok, Thailand
Consultorio Medico, InvesclinicMX
🇲🇽Irapuato, Guanajuato, Mexico
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Medical College of Wisconsin Clinical Trials Office
🇺🇸Milwaukee, Wisconsin, United States
Arizona Digestive Health
🇺🇸Sun City, Arizona, United States
Digestive Health Specialists of the Southeast
🇺🇸Dothan, Alabama, United States
East View Medical Research, LLC
🇺🇸Mobile, Alabama, United States
Om Research, LLC
🇺🇸Lancaster, California, United States
United Medical Doctors
🇺🇸Murrieta, California, United States
ACRC Studies,LLC
🇺🇸San Diego, California, United States
Entertainment Medical Group, Inc.
🇺🇸Los Angeles, California, United States
University of Colorado
🇺🇸Aurora, Colorado, United States
Paradigm Clinical Research Institute
🇺🇸Torrance, California, United States
Gastro Florida
🇺🇸Clearwater, Florida, United States
Florida Center for Gastroenterology
🇺🇸Largo, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
Pediatric & Adult Research Center
🇺🇸Orlando, Florida, United States
Advanced Medical Research Center
🇺🇸Port Orange, Florida, United States
NSB Research
🇺🇸New Smyrna Beach, Florida, United States
Theia Clinical Research, LLC
🇺🇸Saint Petersburg, Florida, United States
Lenus Research & Medical Group, LLC
🇺🇸Sweetwater, Florida, United States
GCP Clinical Research
🇺🇸Tampa, Florida, United States
IMIC, Inc.
🇺🇸Palmetto Bay, Florida, United States
USF Department of Surgery
🇺🇸Tampa, Florida, United States
Guardian Angel Research Center
🇺🇸Tampa, Florida, United States
Florida Medical Clinic, P.A.
🇺🇸Zephyrhills, Florida, United States
Children's Center for Digestive Health Care, LLC
🇺🇸Atlanta, Georgia, United States
Atlanta Center for Gastroenterology, P.C.
🇺🇸Decatur, Georgia, United States
Illinois Gastroenterology Group
🇺🇸Gurnee, Illinois, United States
Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Gastro Center of Maryland
🇺🇸Columbia, Maryland, United States
West Michigan Clinical Research Center
🇺🇸Wyoming, Michigan, United States
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Great Lakes Medical Research, LLC - Mentor
🇺🇸Mentor, Ohio, United States
Tri-Cities Gastroenterology
🇺🇸Kingsport, Tennessee, United States
Great Lakes Medical Research, LLC - Harrisburg
🇺🇸Harrisburg, Pennsylvania, United States
The University of Texas at Austin Dell Medical School
🇺🇸Austin, Texas, United States
GI for Kids
🇺🇸Knoxville, Tennessee, United States
Texas Gastroenterology Associates, PA
🇺🇸Cypress, Texas, United States
Texas Digestive Disease Consultants - Dallas
🇺🇸Dallas, Texas, United States
DHAT Research Institute
🇺🇸Garland, Texas, United States
Rio Grande Gastroenterology
🇺🇸McAllen, Texas, United States
Texas Digestive Disease Consultants - San Marcos
🇺🇸San Marcos, Texas, United States
Baylor Gastroenterology Assoc
🇺🇸Houston, Texas, United States
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Victoria Gastroenterology
🇺🇸Victoria, Texas, United States
Care Access Research LLC
🇺🇸Ogden, Utah, United States
Blue Ridge Medical Research
🇺🇸Lynchburg, Virginia, United States
Washington Gastroenterology
🇺🇸Bellevue, Washington, United States
Marshall University Department of Clinical Research
🇺🇸Huntington, West Virginia, United States
Mautalen Salud e Investigacion
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Fundación Respirar- Centro Médico Dra. De Salvo
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Bankstown-Lidcombe Hospital
🇦🇺Bankstown, New South Wales, Australia
Clinica Adventista Belgrano
🇦🇷Caba, Buenos Aires, Argentina
CICE Sanatorio 9 de Julio
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Instituto de Investigaciones Clínicas Quilmes SRL
🇦🇷Quilmes, Buenos Aires, Argentina
Coral Sea Clinical Research Institute
🇦🇺North Mackay, Queensland, Australia
Coastal Digestive Health
🇦🇺Maroochydore, Queensland, Australia
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Lkh Univ. Klinikum Graz
🇦🇹Graz, Austria
Footscray Hospital
🇦🇺Footscray, Victoria, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
AKH - Medizinische Universität Wien
🇦🇹Wien, Austria
Austin Health
🇦🇺Heidelberg, Victoria, Australia
Liverpool Hospital
🇦🇺Liverpool, Australia
KH der Barmherzigen Brüder Linz, Interne Abteilung
🇦🇹Linz, Austria
Alfred Hospital
🇦🇺Melbourne, Australia
Institution "Gomel Regional Clinical Hospital"
🇧🇾Gomel, Belarus
AZ Sint-Lucas & Volkskliniek
🇧🇪Gent, Belgium
Grodno City Clinical Hospital #4
🇧🇾Grodno, Belarus
Vitebsk Regional Clinical Hospital
🇧🇾Vitebsk, Belarus
University Hospital Antwerp Gastroenterology and Hepatology Department
🇧🇪Edegem, Antwerp, Belgium
Vitebsk Regional Clinical Specialized Center
🇧🇾Vitebsk, Belarus
Dr. Peter Bossuyt - GI Clinical Research Center
🇧🇪Bonheiden, Belgium
UZ Gent - Gastroenterology
🇧🇪Gent, Belgium
UZ Leuven Campus Gasthuisberg
🇧🇪Leuven, Belgium
ZNA Jan Palfijn
🇧🇪Merksem, Belgium
AZ Delta
🇧🇪Roeselare, Belgium
UMHAT "Sv. Georgi", EAD
🇧🇬Plovdiv, Bulgaria
UMHAT Kanev AD, Ruse
🇧🇬Ruse, Bulgaria
Diagnostic-Consultative Center I - Sliven, EOOD
🇧🇬Sliven, Bulgaria
DCC "Alexandrovska", EOOD
🇧🇬Sofia, Bulgaria
ACIBADEM CITY CLINIC TOKUDA HOSPITAL EAD,Clinical Research Center
🇧🇬Sofia, Bulgaria
UMHAT "Tsaritsa Yoanna-ISUL" EAD
🇧🇬Sofia, Bulgaria
UMHATEM "N.I.Pirogov" EAD, Gastroenterology Department/Clinical Research center
🇧🇬Sofia, Bulgaria
Diagnostic Consultation Center CONVEX EOOD
🇧🇬Sofia, Bulgaria
Acibadem City Clinic University Hospital EOOD
🇧🇬Sofia, Bulgaria
Medical Centre MEDICA Plus OOD
🇧🇬Veliko Tarnovo, Bulgaria
Medical center "Nov Rehabilitatsionen Tsentar" EOOD
🇧🇬Stara Zagora, Bulgaria
Heritage Medical Research Clinic
🇨🇦Calgary, Alberta, Canada
Biomedica Research Group
🇨🇱Santiago, Chile
Clinical Research Chile SpA
🇨🇱Valdivia, Chile
Centro de Investigación del Maule SPA
🇨🇱Talca, Chile
Clínica de la Costa Ltda.
🇨🇴Barranquilla, Atlantico, Colombia
Hospital San Juan de Dios Fundacion Cardiomet-Cequin
🇨🇴Armenia, Quindio, Colombia
Clinica de la Mujer Centro de Investigaciones
🇨🇴Bogota, Cundinamarca, Colombia
Clinica farallones centro de investigaciones clinicas CIC
🇨🇴Cali, Valle Del Cauca, Colombia
General Hospital "Dr. Tomislav Bardek" Koprivnica
🇭🇷Koprivnica, Croatia
Clinical Hospital Centre Osijek
🇭🇷Osijek, Croatia
GASTRO JeKa s.r.o.
🇨🇿Klatovy, Czechia
Axon Clinical s. r. o.
🇨🇿Praha, Czechia
Fakultni nemocnice Ostrava
🇨🇿Ostrava-Poruba, Czechia
PreventaMed s.r.o.
🇨🇿Olomouc, Czechia
Nemocnice Na Bulovce
🇨🇿Praha, Czechia
ISCARE I.V.F. a.s.
🇨🇿Praha, Czechia
Oblastni nemocnice Pribram a.s.
🇨🇿Pribram, Czechia
Nemocnice Slany
🇨🇿Slany, Czechia
Herlev Hospital, Gastroenheden, 54Q2
🇩🇰Herlev, Denmark
Aalborg University Hospital, department of medical gastroenterology
🇩🇰Aalborg, Nordjylland, Denmark
Innomedica OÜ
🇪🇪Tallinn, Estonia
West Tallinn Central Hospital
🇪🇪Tallinn, Estonia
North Estonia Medical Centre Foundation
🇪🇪Tallinn, Estonia
CHU Nice - Hôpital de l'Archet 2
🇫🇷Nice Cedex 3, Alpes Maritimes, France
CHU Dijon - Hôpital Bocage Central
🇫🇷Dijon, Côte-d'Or, France
Tartu University Hospital
🇪🇪Tartu, Estonia
Hôpital Rangueil Service Gastro-entérologie et pancreatologie
🇫🇷Toulouse cedex 9, Haute Garonne, France
CHU Montpellier - Hopital Saint Eloi
🇫🇷Montpellier cedex 5, Herault, France
Chu Pontchaillou Rennes
🇫🇷Rennes, Ille Et Vilaine, France
CHU Nantes Hôtel-Dieu
🇫🇷Nantes, Loire Atlantique, France
CHRU-Nancy Brabois
🇫🇷Vandoeuvre les Nancy, Meurthe Et Moselle, France
Unite de Recherche Clinique-Urc
🇫🇷Montfermeil, Seine Saint Denis, France
CHU Grenoble Alpes - Hôpital Michallon
🇫🇷Grenoble, France
Chu Amiens Picardie-Sit Sud
🇫🇷AMIENS cedex 1, Somme, France
Groupement Hospitalier Sud - Hôpital Bicêtre
🇫🇷Le Kremlin Bicêtre, Val De Marne, France
LTD Acad. F. Todua Medical Centre, LTD. Research Institution of Clinical Medicine
🇬🇪Tbilisi, Georgia
LTD Israeli-Georgian medical research clinic Helsicore
🇬🇪Tbilisi, Georgia
LLC Vivamedi
🇬🇪Tbilisi, Georgia
LTD Aversi Clinic
🇬🇪Tbilisi, Georgia
LTD Central University Clinic After Academic N. Kipshidze
🇬🇪Tbilisi, Georgia
Schwerpunktpraxis Bonn
🇩🇪Bonn, Rheinland Pfalz, Germany
LTD Institute of Clinical Cardiology
🇬🇪Tbilisi, Georgia
Charité Universitätsmedizin Berlin - Campus Charité Mitte
🇩🇪Berlin, Germany
Malkhaz Katsiashvili Multiprofile Emergency Medicine Center
🇬🇪Tbilisi, Georgia
Praxis Dr. Joergensen
🇩🇪Remscheid, Nordrhein Westfalen, Germany
Krankenhaus Waldfriede
🇩🇪Berlin, Germany
Clinic for Internal Medicine I, University hospital Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Schleswig Holstein, Germany
Florence-Nightingale-Krankenhaus
🇩🇪Düsseldorf, Germany
Johanna Etienne Krankenhaus
🇩🇪Neuss, Germany
Klinische Forschung Schwerin GmbH
🇩🇪Schwerin, Germany
DRC Gyogyszervizsgalo Kozpont Kft.
🇭🇺Balatonfured, Hungary
SZTE AOK I.st dept. of Internal Medicine.
🇭🇺Szeged, Hungary
Obudai Egeszsegugyi Centrum Kft.
🇭🇺Budapest, Hungary
Bekes Megyei Kozpont Korhaz Dr Rethy Pal Tagkorhaz, 4. Belgyogyaszat es 2. Gasztroenterologia
🇭🇺Bekescsaba, Hungary
Endoexpert Egeszsegugyi Szolgaltato Kft
🇭🇺Budapest, Hungary
Semmelweis Egyetem, II.sz. Belgyogyaszati Klinika
🇭🇺Budapest, Hungary
Debreceni Egyetem Klinikai Kozpont Belgyogyaszati Klinika -Gasztroenterologia
🇭🇺Debrecen, Hungary
Bugat Pal Korhaz
🇭🇺Gyongyos, Hungary
Dept of Gastroenterology, Szent Gyorgy Hospital
🇭🇺Szekesfehervar, Hungary
Nirmal Hospitals Pvt Ltd
🇮🇳Surat, Gujarat, India
Clinfan Ltd. Outpatient Clinic
🇭🇺Szekszard, Hungary
Surat Institute of Digestive Sciences
🇮🇳Surat, Gujarat, India
Fortis Memorial Research Institute
🇮🇳Gurgaon, Haryana, India
Szent Borbala Korhaz
🇭🇺Tatabanya, Hungary
Aster Medcity,Aster DM healthcare Ltd
🇮🇳Kochi, Kerala, India
Government Medical College and Super Speciality Hospital
🇮🇳Nagpur, Maharashtra, India
All India Institute of Medical Sciences
🇮🇳Kochi, Kerala, India
Wolfson Medical Center
🇮🇱Holon, Israel
Bnei Zion Medical Center
🇮🇱Haifa, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Postgraduate department of Medicine, GSVM Medical college
🇮🇳Kanpur, Uttar Pradesh, India
HaEmek Medical Center
🇮🇱Afula, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
Hadassah University Hospital - Ein Kerem
🇮🇱Jerusalem, Israel
Rabin Medical Center-Beilinson Campus
🇮🇱Petach Tikva, Israel
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Azienda Ospedaliera Saverio De Bellis
🇮🇹Castellana Grotte, Bari, Italy
Ospedale di Circolo
🇮🇹Rho, Milano, Italy
Istituto Clinico Humanitas
🇮🇹Rozzano, Milano, Italy
I.R.C.C.S Policlinico San Donato
🇮🇹San Donato Milanese, Milano, Italy
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
🇮🇹Brescia, Italy
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi
🇮🇹Bologna, Italy
Azienda Ospedaliera Ospedale Cannizzaro
🇮🇹Catania, Italy
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Italy
Centro Ricerche Cliniche di Verona
🇮🇹Verona, Italy
Ospedale San Bortolo di Vicenza
🇮🇹Vicenza, Italy
Ospedale Sandro Pertini
🇮🇹Roma, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - CEMAD
🇮🇹Roma, Italy
A.O.U. Policlinico di Modena
🇮🇹Modena, Italy
A.O. Ordine Mauriziano di Torino - P.O. Ospedale Umberto I
🇮🇹Torino, Italy
Nagoya City University Hospital
🇯🇵Nagoya-shi, Aichi, Japan
Koujunkai Daido Clinic
🇯🇵Nagoya, Aichi, Japan
Toyohashi Municipal Hospital
🇯🇵Toyohashi-shi, Aichi, Japan
Fukuoka Tokushukai Hospital
🇯🇵Kasuga, Fukuoka, Japan
Hirosaki University Hospital
🇯🇵Hirosaki-shi, Aomori-ken, Japan
NHO Hirosaki National Hospital
🇯🇵Hirosaki-shi, Aomori, Japan
Tsujinaka Hospital Kashiwanoha
🇯🇵Kashiwa-city, Chiba, Japan
Saiseikai Matsuyama Hospital
🇯🇵Matsuyama-shi, Ehime, Japan
Ehime University Hospital
🇯🇵Toon-shi, Ehime, Japan
JCHO Kyushu Hospital
🇯🇵Kitakyushu-shi, Fukuoka, Japan
Gifu University Hospital
🇯🇵Gifu-shi, Gifu, Japan
Kurume University Hospital
🇯🇵Kurume-shi, Fukuoka, Japan
Ogaki Municipal Hospital
🇯🇵Ogaki-shi, Gifu, Japan
SUBARU Health Insurance Society Ota Memorial Hospital
🇯🇵Ota-shi, Gunma, Japan
Hiroshima University Hospital
🇯🇵Hiroshima-shi, Hiroshima, Japan
NHO Fukuyama Medical Center
🇯🇵Fukuyama-shi, Hiroshima-Ken, Japan
Asahikawa City Hospital
🇯🇵Asahikawa-shi, Hokkaido, Japan
Tokushukai Sapporo Tokushukai Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
NHO Mito Medical Center
🇯🇵Higashi, Ibaraki, Japan
Sapporo-Kosei General Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Yuai Memorial Hospital
🇯🇵Koga-shi, Ibaraki, Japan
Tsuchiura Kyodo General Hospital
🇯🇵Tsuchiura-shi, Ibaraki, Japan
NHO Kanazawa Medical Center
🇯🇵Kanazawa, Ishikawa, Japan
Iwate Medical University Uchimaru Medical Center
🇯🇵Morioka-shi, Iwate, Japan
Jiaikai Izuro Imamura Hospital
🇯🇵Kagoshima-shi, Kagoshima, Japan
Takamatsu Red Cross Hospital
🇯🇵Takamatsu-shi, Kagawa, Japan
Sameshima Hospital
🇯🇵Kagoshima-shi, Kagoshima, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu-shi, Kagawa, Japan
Gokeikai Ofuna Chuo Hospital
🇯🇵Kamakura-shi, Kanagawa-Ken, Japan
Sagamihara Kyodo Hospital
🇯🇵Sagamihara-shi, Kanagawa, Japan
Japanese Red Cross Kumamoto Hospital
🇯🇵Kumamoto-shi, Kumamoto, Japan
Mie University Hospital
🇯🇵Tsu-shi, Mie-Ken, Japan
NHO Yokohama Medical Center
🇯🇵Yokohama-shi, Kanagawa, Japan
NHO Kyoto Medical Center
🇯🇵Kyoto-shi, Kyoto, Japan
Sendai City Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Mie Prefectural General Medical Center
🇯🇵Yokkaichi-City, Mie, Japan
Tohoku University Hospital
🇯🇵Sendai-shi, Miyagi, Japan
JOHAS Tohoku Rosai Hospital
🇯🇵Sendai-shi, Miyagi, Japan
Saiseikai Niigata Hospital
🇯🇵Niigata-shi, Niigata, Japan
Kansai Medical University Hospital
🇯🇵Hirakata-shi, Osaka, Japan
Tokushukai Kishiwada Tokushukai Hospital
🇯🇵Kishiwada-shi, Osaka, Japan
Osaka City University Hospital
🇯🇵Osaka-shi, Osaka, Japan
Japan Community Health care Organization Osaka Hospital
🇯🇵Osaka-shi, Osaka, Japan
Osaka Medical College Hospital
🇯🇵Takatsuki-shi, Osaka, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu-shi, Shiga-ken, Japan
Teikyo University Hospital
🇯🇵Itabashi-ku, Tokyo, Japan
JCHO Saitama Medical Center
🇯🇵Saitama-shi, Saitama-Ken, Japan
St. Luke's International Hospital
🇯🇵Chuo -ku, Tokyo, Japan
Showa General Hospital
🇯🇵Kodaira-shi, Tokyo, Japan
NTT Medical Center Tokyo
🇯🇵Shinagawa-ku, Tokyo, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Tokyo, Japan
Toyama Prefectural Central Hospital
🇯🇵Toyama-shi, Toyama, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama-shi, Wakayama-ken, Japan
Kyungpook National University Hospital
🇰🇷Junggu, Daegu, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seodaemun-gu, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju, Gangwon-do, Korea, Republic of
Saint George Hospital University Medical Center
🇱🇧Beirut, Lebanon
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Hospital Angeles Chihuahua
🇲🇽Chihuahua, Mexico
Hotel Dieu de France Hospital
🇱🇧Beirut, Lebanon
American University of Beirut Medical Center
🇱🇧Beirut, Lebanon
Republican Panevezys Hospital, Department of Gastroenterology
🇱🇹Panevezys, Lithuania
UAB "Inlita", Santaros Clinical Trials Centre
🇱🇹Vilnius, Lithuania
Vilnius University Hospital Santaros Clinics, Center of Hepatology, Gastroenterology and Dietology
🇱🇹Vilnius, Lithuania
Centro de Investigacion Medico Biologica y Terapia Avanzada s.c.
🇲🇽Guadalajara, Jalisco, Mexico
Scientia Investigación Clínica S.C.
🇲🇽Chihuahua, Mexico
Faicic S. de R.L. de Cv
🇲🇽Veracruz, Mexico
Rtl Sm Srl
🇲🇩Chisinau, Moldova, Republic of
Republican Clinical Hospital, ARENSIA Exploratory Medicine
🇲🇩Chisinau, Moldova, Republic of
Timofei Mosneaga Republican Clinical Hospital, Department of Gastroenterology
🇲🇩Chisinau, Moldova, Republic of
Zuyderland Medisch Centrum - Sittard-Geleen
🇳🇱Geleen, Netherlands
ETZ Elisabeth
🇳🇱Tilburg, Netherlands
Gastromed Kralisz, Romatowski, Stachurska sp.j
🇵🇱Białystok, Poland
RTL SM SRL, Institutia Medico- Sanitara Publica Spitalul Clinic, Sectia Proctologie
🇲🇩Chisinau, Moldova, Republic of
Centrum Dentystyczno-Lekarskie Promedica Joanna Markiewicz
🇵🇱Bedzin, Poland
Centrum Medyczne Pratia Czestochowa
🇵🇱Czestochowa, Poland
Karkonoskie Centrum Badan Klinicznych Lexmedica
🇵🇱Jelenia Gora, Poland
Centrum Medyczne Plejady
🇵🇱Kraków, Poland
Allmedica Badania Kliniczne Sp. z o.o. Sp.k.
🇵🇱Nowy Targ, Poland
Topolowa Medicenter Mrozek & Wspolnicy Spolka Jawna
🇵🇱Kraków, Poland
AmiCare Sp. z O.O. Sp.K.
🇵🇱Lodz, Poland
Centrum Medyczne Grunwald
🇵🇱Poznan, Poland
IP Clinic
🇵🇱Lodz, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
DC-MED
🇵🇱Swidnica, Poland
Centro Hospitalar de São João, EPE
🇵🇹Porto, Portugal
Centralny Szpital Kliniczny MSW w Warszawie
🇵🇱Warsaw, Poland
Centrum Zdrowia MDM
🇵🇱Warsaw, Poland
Centro Hospitalar e Universitário de Coimbra Serviço Gastrenterologia
🇵🇹Coimbra, Portugal
Hospital da Luz Lisboa
🇵🇹Lisboa, Portugal
Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E
🇵🇹Vila Nova de Gaia, Portugal
S.C. Centrul Medical Unirea SRL
🇷🇴Bucharest, Romania
S.C Policlinica CCBR S.R.L
🇷🇴Bucuresti, Romania
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
S.C MedLife SA
🇷🇴Bucuresti, Romania
S.C Delta Health Care S.R.L, Ponderas Academic Hospital
🇷🇴Bucuresti, Romania
Institutul Clinic Fundeni
🇷🇴Bucuresti, Romania
S.C Euroclinic Hospital S.A
🇷🇴Bucuresti, Romania
Spitalul Clinic Judetean de Urgenta Cluj Napoca
🇷🇴Cluj-Napoca, Romania
LLC "Multidisciplinary Medical Clinic "Anthurium"
🇷🇺Barnaul, Russian Federation
Spitalul Clinic Judetean de Urgenta Craiova
🇷🇴Craiova, Romania
S.C Pelican Impex S.R.L
🇷🇴Oradea, Romania
LLC "Alyans Biomedical- Ural Group"
🇷🇺Izhevsk, Russian Federation
Kazan State Medical University
🇷🇺Kazan, Russian Federation
SAIH "Kemerovo Regional Clinical Hospital"
🇷🇺Kemerovo, Russian Federation
SBIH of Nizhniy Novgorod region "Nizhniy Novgorod Regional Clinical Hospital n.a. N.A. Semashko"
🇷🇺Nizhniy Novgorod, Russian Federation
CDC "Ultramed"
🇷🇺Omsk, Russian Federation
State Budgetary Healthcare Institution "Penza Region Clinical Hospital n.a. N.N. Burdenko"
🇷🇺Penza, Russian Federation
LLC Medicine Center SibNovoMed
🇷🇺Novosibirsk, Russian Federation
LLC SM-Clinic
🇷🇺Saint-Peterburg, Russian Federation
Federal state Budgetary Educational Institution of Higher Education "North-Western Medical University"
🇷🇺Saint-Petersburg, Russian Federation
Irkutsk State Medical Academy of Continuing Education
🇷🇺Samara, Russian Federation
LLC Medical Company "Hepatologist"
🇷🇺Samara, Russian Federation
LLC Uromed
🇷🇺Smolensk, Russian Federation
Stavropol Regional Clinical Diagnostic Centre
🇷🇺Stavropol, Russian Federation
City Clinical Hospital #8
🇷🇺Yaroslavl, Russian Federation
Clinical Center Bezanijska Kosa
🇷🇸Belgrade, Serbia
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Clinical Health Center Zvezdara
🇷🇸Belgrade, Serbia
Fakultna nemocnica s poliklinikou F.D. Roosevelta
🇸🇰Banska Bystrica, Slovakia
Gastro I, s.r.o.
🇸🇰Presov, Slovakia
Johese Clinical Research: Unitas
🇿🇦Lyttelton, Centurion, South Africa
Johese Clinical Research
🇿🇦Midstream, Centurion, South Africa
Lenasia Clinical Trial Centre
🇿🇦Lenasia, Gauteng, South Africa
Centro Médico Teknon
🇪🇸Barcelona, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital General Universitario de Alicante
🇪🇸Alicante, Spain
Dr JP Wright Practice
🇿🇦Cape Town, Western Cape, South Africa
Hacettepe University Medical Faculty
🇹🇷Ankara, Turkey
Hospital Universitario de Gran Canaria Dr. Negrin
🇪🇸Las Palmas, Spain
Kantonsspital Baden
🇨🇭Baden, Switzerland
Berner IBD study group c/o Gastroenterologische Praxis Balsiger, Seibold &Partner
🇨🇭Bern, Switzerland
Gazi University Medical Faculty
🇹🇷Ankara, Turkey
Antalya Training and Research Hospital
🇹🇷Antalya, Turkey
Kocaeli University Research and Training Hospital
🇹🇷Kocaeli, Turkey
Karadeniz Tecnical Uni. Med. Fac.
🇹🇷Trabzon, Turkey
Municipal non-profit enterprise Regional Clinical Hospital of Ivano-Frankivsk Regional Council, Ga
🇺🇦Ivano-Frankivsk, Ukraine
I.I.Mechnykov Dnipropetrovsk Regional Clinical Hospital
🇺🇦Dnipro, Ukraine
Department of Propaedeutics of Internal Medicine Ivano-Frankivsk National Medical University
🇺🇦Ivano-Frankivsk, Ukraine
CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 of KCC
🇺🇦Kharkiv, Ukraine
Communal Non-Commercial Enterprise Lviv Clinical Hospital of Emergency Medical Care
🇺🇦Lviv, Ukraine
Communal Non-commercial Enterprise of Kharkiv Regional Council Regional Clinical Hospital
🇺🇦Kharkiv, Ukraine
Communal Non-Commercial Enterprise City Clinical Hospital #13 of Kharkiv City Council
🇺🇦Kharkiv, Ukraine
Communal Noncommercial Enterprise Ye.Ye. Karabelesh Kherson City Clinical Hospital of Kherson City
🇺🇦Kherson, Ukraine
Kremenchuk first city hospital n.a. O.T. Bohaievskyi
🇺🇦Kremenchuk, Ukraine
Kyiv CCH #18 Dept of Proctology O. O. Bogomolets NMU
🇺🇦Kyiv, Ukraine
Kyiv City Clinical Hospital N 1
🇺🇦Kyiv, Ukraine
Odesa regional clinical hospital, regional center of gastroenterology, surgical department
🇺🇦Odesa, Ukraine
Medical Clinical Investigational Center of Medical Center Health Clinic LLC
🇺🇦Vinnytsia, Ukraine
A. Novak Transcarpathian Regional Clinical Hospital
🇺🇦Uzhgorod, Ukraine
M.I. Pyrogov VRCH Dept of Gastroenterology M.I. Pyrogov VNMU
🇺🇦Vinnytsia, Ukraine
Norfolk and Norwich University Hospital
🇬🇧Norwich, Norfolk, United Kingdom
Guy's and Saint Thomas NHS Foundation Trust
🇬🇧London, Greater London, United Kingdom
SRI of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU
🇺🇦Vinnytsia, Ukraine
Yeovil District Hospital
🇬🇧Yeovil, Somerset, United Kingdom
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
InspirePharma S. de R. L. de C.V.
🇲🇽Monterrey, Nuevo León, Mexico
Texas Digestive Disease Consultants
🇺🇸Baton Rouge, Louisiana, United States
Life Medical Center & Research, Inc
🇺🇸Miami Lakes, Florida, United States
Texas Clinical Research Institute, LLC
🇺🇸Arlington, Texas, United States
Ruby Hall Clinic
🇮🇳Pune, Maharashtra, India