Etrasimod Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis
- Registration Number
- NCT03945188
- Lead Sponsor
- Arena Pharmaceuticals
- Brief Summary
The purpose of this study is to determine whether oral etrasimod is a safe and effective treatment for moderately to severely active ulcerative colitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 433
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo - Etrasimod 2 mg Etrasimod -
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving Clinical Remission at Week 12 At Week 12 Clinical remission was based on the modified Mayo score (MMS). The MMS is a composite score of 3 assessments consisting of participant-reported symptoms using daily eDiary and centrally read endoscopy: stool frequency (SF), rectal bleeding (RB) and endoscopic score (ES). Clinical remission was defined as SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline), RB subscore = 0, and ES ≤ 1 (excluding friability). Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving Clinical Remission at Week 52 At Week 52 Clinical remission was based on the MMS which is a composite score of 3 assessments: SF, RB and ES. Clinical remission was defined as SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline), RB subscore = 0, and ES ≤ 1 (excluding friability). Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Endoscopic Improvement at Week 12 At Week 12 Endoscopic improvement was defined as an ES ≤ 1 (excluding friability). The ES ranged from 0 to 3 (where 0 = normal/inactive disease and 3 = severe disease).
Percentage of Participants Achieving Symptomatic Remission at Week 52 At Week 52 Symptomatic remission was defined as an SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline) and RB subscore = 0. The SF subscore ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB subscore ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). Higher scores indicate more severe disease.
Percentage of Participants With Mucosal Healing at Week 12 At Week 12 Mucosal healing was defined as an ES ≤ 1 (excluding friability) with histologic remission measured by a Geboes Index score \< 2.0. The ES ranged from 0 to 3 (where 0 = normal/inactive disease and 3 = severe disease). The Geboes score grading system is a validated score for evaluating histologic disease activity in UC as follows: grade 0 = structural and architectural changes; grade 1 = chronic inflammatory infiltrate; grade 2 = lamina propria neutrophils and eosinophils; grade 3 = neutrophils in the epithelium; grade 4 = crypt destruction; grade 5 = erosions or ulceration. A higher Geboes score indicates more severe disease.
Percentage of Participants Achieving Symptomatic Remission at Week 12 At Week 12 Symptomatic remission was defined as an SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline) and RB subscore = 0. The SF subscore ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB subscore ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). Higher scores indicate more severe disease.
Percentage of Participants With Mucosal Healing at Both Weeks 12 and 52 At Weeks 12 and 52 Mucosal healing was defined as an ES ≤ 1 (excluding friability) with histologic remission measured by a Geboes Index score \< 2.0. The ES ranged from 0 to 3 (where 0 = normal/inactive disease and 3 = severe disease). The Geboes score grading system is a validated score for evaluating histologic disease activity in UC as follows: grade 0 = structural and architectural changes; grade 1 = chronic inflammatory infiltrate; grade 2 = lamina propria neutrophils and eosinophils; grade 3 = neutrophils in the epithelium; grade 4 = crypt destruction; grade 5 = erosions or ulceration. A higher Geboes score indicates more severe disease.
Percentage of Participants Achieving Symptomatic Remission by Study Visit At Weeks 2, 4, 8, 16, 20, 24, 32, 40, and 48 Symptomatic remission was defined as an SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline) and RB subscore = 0. The SF subscore ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB subscore ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). Higher scores indicate more severe disease.
Percentage of Participants Achieving Clinical Response at Week 52 At Week 52 Clinical response was based on the MMS which is a composite score of 3 assessments: SF, RB and ES. Clinical response was defined as a ≥ 2-point and ≥ 30% decrease from Baseline MMS, and a ≥ 1-point decrease from Baseline in RB subscore or an absolute RB sub-score ≤ 1. Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving Clinical Response at Both Weeks 12 and 52 At Weeks 12 and 52 Clinical response was based on the MMS which is a composite score of 3 assessments: SF, RB and ES. Clinical response was defined as a ≥ 2-point and ≥ 30% decrease from Baseline MMS, and a ≥ 1-point decrease from Baseline in RB subscore or an absolute RB subscore ≤ 1. Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving Endoscopic Normalization at Week 12 At Week 12 Endoscopic normalization was defined as an ES = 0. The ES ranged from 0 to 3 (where 0= normal/inactive disease and 3= severe disease).
Percentage of Participants Achieving Non-invasive Clinical Response by Study Visit At Weeks 2, 4, 8, 12, 16, 20, 24, 32, 40, 48, and 52 Non-invasive clinical response was defined as a ≥ 30% decrease from Baseline in composite RB and SF subscores, and a ≥ 1-point decrease from Baseline in RB subscore or RB subscore ≤ 1. The SF subscore ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB subscore ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). The composite RB and SF score range was from 0 to 6, with higher scores indicating more severe disease.
Percentage of Participants Achieving Endoscopic Improvement at Week 52 At Week 52 Endoscopic improvement was defined as an ES ≤ 1 (excluding friability). The ES ranged from 0 to 3 (where 0 = normal/inactive disease and 3 = severe disease).
Percentage of Participants With Mucosal Healing at Week 52 At Week 52 Mucosal healing was defined as an ES ≤ 1 (excluding friability) with histologic remission measured by a Geboes Index score \< 2.0. The ES ranged from 0 to 3 (where 0 = normal/inactive disease and 3 = severe disease). The Geboes score grading system is a validated score for evaluating histologic disease activity in UC as follows: grade 0 = structural and architectural changes; grade 1 = chronic inflammatory infiltrate; grade 2 = lamina propria neutrophils and eosinophils; grade 3 = neutrophils in the epithelium; grade 4 = crypt destruction; grade 5 = erosions or ulceration. A higher Geboes score indicates more severe disease.
Percentage of Participants Achieving Sustained Clinical Remission at Both Weeks 12 and 52 At Weeks 12 and 52 Sustained clinical remission was defined as an SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline), RB subscore = 0, and ES ≤ 1 (excluding friability) at both Week 12 and Week 52. Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving Clinical Response at Week 12 At Week 12 Clinical response was based on the MMS which is a composite score of 3 assessments: SF, RB and ES. Clinical response was defined as a ≥ 2-point and ≥ 30% decrease from Baseline MMS, and a ≥ 1-point decrease from Baseline in RB subscore or an absolute RB subscore ≤ 1. Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving Endoscopic Normalization at Week 52 At Week 52 Endoscopic normalization was defined as an ES = 0. The ES ranged from 0 to 3 (where 0= normal/inactive disease and 3= severe disease).
Percentage of Participants Achieving Endoscopic Normalization at Both Weeks 12 and 52 At Weeks 12 and 52 Endoscopic normalization was defined as an ES = 0. The ES ranged from 0 to 3 (where 0= normal/inactive disease and 3= severe disease).
Percentage of Participants Achieving Complete Symptomatic Remission by Study Visit At Weeks 2, 4, 8, 12, 16, 20, 24, 32, 40, 48 and 52 Complete symptomatic remission was defined as an SF subscore = 0 and RB subscore = 0. The SF subscore ranged from 0 to 3 (where 0 = normal number of stools and 3 = at least 5 stools more than normal) and RB subscore ranged from 0 to 3 (where 0 = no blood and 3 = blood alone passes). Higher scores indicate more severe disease.
Percentage of Participants Achieving Symptomatic Response by Study Visit At Weeks 2, 4, 8, 12, 16, 20, 24, 32, 40, 48, and 52 Symptomatic response was defined as a ≥ 30% decrease from Baseline in composite RB and SF subscores. The SF subscore ranged from 0 to 3 (where 0= normal number of stools and 3= at least 5 stools more than normal) and RB subscore ranged from 0 to 3 (where 0= no blood and 3= blood alone passes). The composite RB and SF score range was from 0 to 6, with higher scores indicating more severe disease.
Percentage of Participants Achieving Clinical Remission at Week 52 Among Participants in Clinical Response at Week 12 At Week 52 Clinical remission and clinical response were based on the MMS which is a composite of 3 assessments: SF, RB and ES. Clinical remission was defined as an SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline), RB subscore = 0, and ES ≤ 1 (excluding friability). Clinical response was defined as a ≥ 2-point and ≥ 30% decrease from Baseline MMS, and a ≥ 1-point decrease from Baseline in RB subscore or an absolute RB subscore ≤ 1. Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving Corticosteroid-free Clinical Remission at Week 52 At Week 52 Corticosteroid-free clinical remission was defined as an SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline), RB subscore = 0, ES ≤ 1 (excluding friability), and have not received corticosteroids for ≥ 12 weeks in the 40-Week Treatment Period. Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Percentage of Participants Achieving 4-week Corticosteroid-free Clinical Remission at Week 52 Among Participants Receiving Corticosteroids at Baseline At Week 52 Four-week corticosteroid-free clinical remission was defined as an SF subscore = 0 (or = 1 with a ≥ 1-point decrease from Baseline), RB subscore = 0, and ES ≤ 1, and have not received corticosteroids for ≥ 4 weeks in the 40-Week Treatment Period. Each component subscore ranged from 0 to 3 and total score range of the MMS was from 0 to 9, with higher scores indicating more severe disease.
Trial Locations
- Locations (312)
Digestive Health Specialists of the Southeast
🇺🇸Dothan, Alabama, United States
Om Research, LLC
🇺🇸Lancaster, California, United States
InspirePharma S. de R. L. de C.V.
🇲🇽Monterrey, Nuevo León, Mexico
Atlanta Gastroenterology Associates LLC
🇺🇸Atlanta, Georgia, United States
Mautalen Salud e Investigacion
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Johese Clinical Research
🇿🇦Midstream, Centurion, South Africa
Bankstown-Lidcombe Hospital
🇦🇺Bankstown, New South Wales, Australia
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
DCC "Alexandrovska", EOOD
🇧🇬Sofia, Bulgaria
Mount Sinai Hospital
🇨🇦Toronto, Ontario, Canada
Enroll SpA
🇨🇱Santiago, Chile
Clinical Hospital Dubrava
🇭🇷Zagreb, Croatia
University hospital centre Zagreb
🇭🇷Zagreb, Croatia
PreventaMed s.r.o.
🇨🇿Olomouc, Czechia
Nemocnice Na Bulovce
🇨🇿Praha, Czechia
LTD Institute of Clinical Cardiology
🇬🇪Tbilisi, Georgia
Bekes Megyei Kozpont Korhaz Dr Rethy Pal Tagkorhaz, 4. Belgyogyaszat es 2. Gasztroenterologia
🇭🇺Bekescsaba, Hungary
1th Dept of Gastroenterology, Szent Gyorgy Hospital
🇭🇺Szekesfehervar, Hungary
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Hospital Angeles Chihuahua
🇲🇽Chihuahua, Mexico
Zuyderland Medisch Centrum - Sittard-Geleen
🇳🇱Geleen, Netherlands
LLC "Alyans Biomedical- Ural Group"
🇷🇺Irkutsk, Russian Federation
Uludag University Medical Faculty
🇹🇷Beşevler, Yenimahalle / Ankara, Turkey
LLC SM-Clinic
🇷🇺Saint Petersburg, Russian Federation
LLC "Gastroenterological centre Expert"
🇷🇺Saint Petersburg, Russian Federation
Irkutsk State Medical Academy of Continuing Education
🇷🇺Samara, Russian Federation
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
San Diego Gastroenterology Medical Associates
🇺🇸San Diego, California, United States
ACRC Studies, LLC
🇺🇸San Diego, California, United States
Javier Sobrado, MD
🇺🇸Miami, Florida, United States
Sierra Clinical Research
🇺🇸Las Vegas, Nevada, United States
CliniCore Texas
🇺🇸Houston, Texas, United States
Baylor Gastroenterology Assoc
🇺🇸Houston, Texas, United States
Virginia Mason Medical Center
🇺🇸Seattle, Washington, United States
UZ Gent Gastroenterology
🇧🇪Gent, Belgium
Duke University Medical Center GI Clinical Research Unit
🇺🇸Durham, North Carolina, United States
Medicenter Nowy Targ
🇵🇱Nowy Targ, Poland
Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar, Verona, Italy
Supaporn Lertkawinanan
🇹🇭Pathum Wan, Bangkok, Thailand
Faculty of Medicine Siriraj Hospital
🇹🇭Bangkoknoi, Bangkok, Thailand
Phramongkutklao Hospital
🇹🇭Ratchathewi, Bangkok, Thailand
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Shweta Paliwal/Vipin Kumar Jain
🇮🇳Jaipur, Rajasthan, India
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Azienda Ospedaliera Saverio De Bellis
🇮🇹Castellana Grotte, Bari, Italy
Ospedale di Circolo
🇮🇹Rho, Milano, Italy
Spedali Civili di Brescia, U.O. Gastroenterologia
🇮🇹Brescia, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - CEMAD
🇮🇹Roma, Italy
Digestive Disease Specialists, Inc.
🇺🇸Oklahoma City, Oklahoma, United States
USF Physicians Group
🇺🇸Tampa, Florida, United States
Guardian Angel Research Center
🇺🇸Tampa, Florida, United States
ISCARE I.V.F. a.s.
🇨🇿Praha, Czechia
Arizona Digestive Health
🇺🇸Sun City, Arizona, United States
Entertainment Medical Group, Inc.
🇺🇸Los Angeles, California, United States
United Medical Doctors
🇺🇸Murrieta, California, United States
Florida Center for Gastroenterology
🇺🇸Clearwater, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
Office of Dr Meckstroth
🇺🇸Naples, Florida, United States
NSB Research
🇺🇸New Smyrna Beach, Florida, United States
Sarkis Clinical Trials - Parent
🇺🇸Ocala, Florida, United States
Advanced Medical Research Center
🇺🇸Port Orange, Florida, United States
IMIC, Inc.
🇺🇸Palmetto Bay, Florida, United States
Theia Clinical Research, LLC
🇺🇸Saint Petersburg, Florida, United States
Advanced Research Institute, Inc.
🇺🇸Saint Petersburg, Florida, United States
Lenus Research & Medical Group
🇺🇸Sweetwater, Florida, United States
GCP Clinical Research
🇺🇸Tampa, Florida, United States
Florida Medical Clinic, P.A.
🇺🇸Zephyrhills, Florida, United States
Atlanta Gastroenterology Associates
🇺🇸Atlanta, Georgia, United States
ASCLEPES Research Centers, P.C.
🇺🇸Weeki Wachee, Florida, United States
Gen1 Research
🇺🇸Moline, Illinois, United States
Atlanta Center for Gastroenterology, P.C.
🇺🇸Decatur, Georgia, United States
Illinois Gastroenterology Group
🇺🇸Gurnee, Illinois, United States
Texas Digestive Disease Consultants
🇺🇸Dallas, Texas, United States
Clinical Trials Management, LLC
🇺🇸Metairie, Louisiana, United States
CroNOLA
🇺🇸Houma, Louisiana, United States
Clinical Trials of SW Louisiana, LLC
🇺🇸Lake Charles, Louisiana, United States
Gastrointestinal Associates
🇺🇸Flowood, Mississippi, United States
Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Robert Ferguson MD
🇺🇸West Bloomfield, Michigan, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
Great Lakes Medical Research, LLC
🇺🇸Harrisburg, Pennsylvania, United States
Care Access Research
🇺🇸Poland, Ohio, United States
GI for Kids
🇺🇸Knoxville, Tennessee, United States
Texas Gastroenterology Associates, PA
🇺🇸Cypress, Texas, United States
Texas Clinical Research Institute, LLC
🇺🇸Arlington, Texas, United States
Coastal Medical Group
🇺🇸Baytown, Texas, United States
Digestive Health Associates of Texas
🇺🇸Garland, Texas, United States
Biopharma Informatic, Inc. Research Center
🇺🇸Pasadena, Texas, United States
Rio Grande Gastroenterology
🇺🇸McAllen, Texas, United States
Texas Digestive Disease Consultants - San Marcos
🇺🇸San Marcos, Texas, United States
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Victoria Gastroenterology
🇺🇸Victoria, Texas, United States
Washington Gastroenterology
🇺🇸Bellevue, Washington, United States
Blue Ridge Medical Research
🇺🇸Lynchburg, Virginia, United States
Clinica Adventista Belgrano
🇦🇷Caba, Buenos Aires, Argentina
Marshall University Department of Clinical Research
🇺🇸Huntington, West Virginia, United States
Fundación Respirar- Centro Médico Dra. De Salvo
🇦🇷Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
CICE Sanatorio 9 de Julio
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Nepean Hospital
🇦🇺Kingswood, New South Wales, Australia
Coastal Digestive Health Pty Ltd
🇦🇺Maroochydore, Queensland, Australia
Coral Sea Clinical Research Institute
🇦🇺North Mackay, Queensland, Australia
Royal Melbourne Hospital
🇦🇺Parkville, Victoria, Australia
Institution "Gomel Regional Clinical Hospital"
🇧🇾Gomel, Belarus
AKH - Medizinische Universität Wien
🇦🇹Wien, Austria
Wilhelminenspital der Stadt Wien
🇦🇹Wien, Austria
Grodno City Clinical Hospital #4
🇧🇾Grodno, Belarus
Health Care Institution "10th City Clinical Hospital"
🇧🇾Minsk, Belarus
Vitebsk Regional Clinical Hospital
🇧🇾Vitebsk, Belarus
Vitebsk Regional Clinical Specialized Center
🇧🇾Vitebsk, Belarus
AZ Sint-Lucas & Volkskliniek
🇧🇪Gent, Belgium
ZNA Jan Palfijn
🇧🇪Merksem, Belgium
AZ Delta
🇧🇪Roeselare, Belgium
Medical center Medconsult Pleven OOD
🇧🇬Pleven, Bulgaria
Diagnostic-Consultative Center I - Sliven, EOOD
🇧🇬Sliven, Bulgaria
ACIBADEM CITY CLINIC TOKUDA HOSPITAL EAD,Clinical Research Center
🇧🇬Sofia, Bulgaria
UMHAT Kanev AD, Ruse
🇧🇬Ruse, Bulgaria
UMHAT "Sv. Ivan Rilski", EAD,Clinic of gastroenterology
🇧🇬Sofia, Bulgaria
UMHAT Tsaritsa Yoanna-ISUL EAD
🇧🇬Sofia, Bulgaria
UMHATEM "N.I.Pirogov" EAD, Gastroenterology Department/Clinical Research center, next to the chimney
🇧🇬Sofia, Bulgaria
Medical Center Nov Rehabilitatsionen Tsentar EOOD
🇧🇬Stara Zagora, Bulgaria
Diagnostic Consultation Center CONVEX EOOD
🇧🇬Sofia, Bulgaria
Hospital Sotero del Rio
🇨🇱Santiago, Chile
Centro de Investigación del Maule SPA
🇨🇱Talca, Chile
Clinical Research Chile SpA
🇨🇱Valdivia, Chile
General Hospital "Dr.Tomislav Bardek" Koprivnica
🇭🇷Koprivnica, Croatia
Clinical Hospital Centre Osijek
🇭🇷Osijek, Croatia
General Hospital Zadar
🇭🇷Zadar, Croatia
Clinical Hospital Sveti Duh
🇭🇷Zagreb, Croatia
Polyclinic Bonifarm
🇭🇷Zagreb, Croatia
GASTRO JeKa, s.r.o.
🇨🇿Klatovy, Czechia
Fakultni nemocnice u svate Anny v Brne
🇨🇿Brno, Czechia
Hepato-Gastroenterologie HK, s.r.o.,
🇨🇿Hradec Kralove, Czechia
West Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Fakultni nemocnice Ostrava
🇨🇿Ostrava-Poruba, Czechia
Herlev Hospital
🇩🇰Herlev, Denmark
Nemocnice Slany
🇨🇿Slany, Czechia
Aalborg University Hospital, department of medical gastroenterology
🇩🇰Aalborg, Nordjylland, Denmark
CHU Montpellier - HOPITAL SAINT-ELOI
🇫🇷Montpellier cedex 5, Herault, France
Innomedica OÜ
🇪🇪Tallinn, Estonia
CHU Nice - Hôpital de l'Archet 2
🇫🇷Nice Cedex 3, Alpes Maritimes, France
North Estonia Medical Centre Foundation
🇪🇪Tallinn, Estonia
Krankenhaus Waldfriede
🇩🇪Berlin, Germany
LTD Israeli-Georgian Medical Research clinic Helsicore
🇬🇪Tbilisi, Georgia
CHU Nantes Hôtel-Dieu
🇫🇷Nantes, Loire Atlantique, France
LLC Vivamedi
🇬🇪Tbilisi, Georgia
CHRU-Nancy Brabois
🇫🇷Vandoeuvre-lès-Nancy, France
LTD Acad. F. Todua Medical Center - LTD Research Institute of Clinical Medicine
🇬🇪Tbilisi, Georgia
CHU Grenoble Alpes - Hôpital Michallon
🇫🇷Grenoble, France
JSC Infectious Diseases, AIDS and Clinical Immunology Research Center
🇬🇪Tbilisi, Georgia
LTD Central University Clinic After Academic N. Kipshidze
🇬🇪Tbilisi, Georgia
LTD Aversi Clinic
🇬🇪Tbilisi, Georgia
Malkhaz Katsiashvili Multiprofile Emergency Medicine Center
🇬🇪Tbilisi, Georgia
Schwerpunktpraxis Bonn
🇩🇪Bonn, Rheinland Pfalz, Germany
Praxis Dr. Joergensen
🇩🇪Remscheid, Nordrhein Westfalen, Germany
Florence-Nightingale-Krankenhaus
🇩🇪Düsseldorf, Germany
Clinic for Internal Medicine I, University hospital Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Schleswig Holstein, Germany
Johanna Etienne Krankenhaus
🇩🇪Neuss, Germany
DRC Gyogyszervizsgalo Kozpont Kft.
🇭🇺Balatonfured, Hungary
Klinische Forschung Schwerin GmbH
🇩🇪Schwerin, Germany
Obudai Egeszsegugyi Centrum Kft.
🇭🇺Budapest, Hungary
Pannonia Maganorvosi Centrum
🇭🇺Budapest, Hungary
Bugat Pal Korhaz
🇭🇺Gyongyos, Hungary
SZTE AOK I.st dept. of Internal Medicine.
🇭🇺Szeged, Hungary
Clinfan Ltd. Outpatient Clinic
🇭🇺Szekszard, Hungary
Szent Borbala Korhaz
🇭🇺Tatabanya, Hungary
Nirmal Hospitals Pvt Ltd
🇮🇳Surat, Gujarat, India
Asian Institute of Gastroenterology
🇮🇳Hyderabad, Andhra Pradesh, India
Surat Institute of Digestive Sciences
🇮🇳Surat, Gujarat, India
Aster Medcity,Aster DM healthcare Ltd
🇮🇳Kochi, Kerala, India
Fortis Memorial Research Institute
🇮🇳Gurgaon, Haryana, India
Midas Multispeciality Hospital-Nagpur
🇮🇳Nagpur, Maharashtra, India
Postgraduate department of Medicine, GSVM Medical college
🇮🇳Kanpur, Uttar Pradesh, India
Bnei Zion Medical Center
🇮🇱Haifa, Israel
Wolfson Medical Center
🇮🇱Holon, Israel
HaEmek Medical Center
🇮🇱Afula, Israel
Hadassah University Hospital - Ein Kerem
🇮🇱Jerusalem, Israel
Rabin Medical Center
🇮🇱Petach Tikva, Israel
Galilee Medical Center
🇮🇱Nahariya, Israel
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
Kaplan Medical Center
🇮🇱Rehovot, Israel
I.R.C.C.S Policlinico San Donato
🇮🇹San Donato Milanese, Milano, Italy
Azienda Ospedaliera Ospedale Cannizzaro
🇮🇹Catania, Italy
Magna Graecia University
🇮🇹Catanzaro, Italy
Ospedale Sandro Pertini
🇮🇹Roma, Italy
A.O.U. Policlinico di Modena
🇮🇹Modena, Italy
Kyungpook National University Hospital
🇰🇷Junggu, Daegu, Korea, Republic of
Ospedale San Bortolo di Vicenza
🇮🇹Vicenza, Italy
P. Stradins Clinical University Hospital
🇱🇻Riga, Latvia
Wonju Severance Christian Hospital
🇰🇷Wonju, Gangwon-do, Korea, Republic of
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon-si, Gyeonggi-do, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Seodaemun-gu, Korea, Republic of
Kaunas Clinical Hospital
🇱🇹Kaunas, Lithuania
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Klaipeda University Hospital, Department of Gastroenterology
🇱🇹Klaipeda, Lithuania
Republican Panevezys Hospital, Department of Gastroenterology
🇱🇹Panevezys, Lithuania
Saint George University Hospital Medical Center
🇱🇧Beirut, Lebanon
UAB "Inlita", Santaros Clinical Trials Centre
🇱🇹Vilnius, Lithuania
Vilnius University Hospital Santaros Clinics, Center of Hepatology, Gastroenterology and Dietology
🇱🇹Vilnius, Lithuania
Centro de Investigacion Medico Biologica y Terapia Avanzada s.c.
🇲🇽Guadalajara, Jalisco, Mexico
Faicic S. de R.L. de Cv
🇲🇽Veracruz, Mexico
Scientia Investigación Clínica S.C.
🇲🇽Chihuahua, Mexico
Clinical Hospital of the Ministry of Health, Labor and Social Protection
🇲🇩Chisinau, Moldova, Republic of
Rtl Sm Srl
🇲🇩Chisinau, Moldova, Republic of
Timofei Mosneaga Republican Clinical Hospital, Department of Gastroenterology
🇲🇩Chisinau, Moldova, Republic of
RTL SM SRL, Institutia Medico-Sanitara Publica Spitalul Clinic, Sectia Proctologie
🇲🇩Chisinau, Moldova, Republic of
Centrum Dentystyczno-Lekarskie Promedica Joanna Markiewicz
🇵🇱Bedzin, Poland
Gastromed Kralisz, Romatowski, Stachurska sp.j
🇵🇱Białystok, Poland
ETZ Elisabeth
🇳🇱Tilburg, Netherlands
Topolowa Medicenter Mrozek & Wspolnicy Spolka Jawna
🇵🇱Kraków, Poland
AmiCare Sp. z O.O. Sp.K.
🇵🇱Lodz, Poland
Karkonoskie Centrum Badan Klinicznych Lexmedica
🇵🇱Jelenia Gora, Poland
Allmedica Badania Kliniczne Sp. z o.o. Sp.k.
🇵🇱Nowy Targ, Poland
Med-Gastr Przychodnia Specjalistyczna
🇵🇱Lodz, Poland
Centrum Medyczne Grunwald
🇵🇱Poznan, Poland
Medicome Sp. Zo.O.
🇵🇱Oswiecim, Poland
SOLUMED Centrum Medyczne
🇵🇱Poznan, Poland
Centrum Medyczne Medyk
🇵🇱Rzeszow, Poland
ENDOSKOPIA Sp.zo.o
🇵🇱Sopot, Poland
Twoja Przychodnia-Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
Centrum Zdrowia MDM
🇵🇱Warsaw, Poland
Centralny Szpital Kliniczny MSW w Warszawie
🇵🇱Warsaw, Poland
Centrum Medyczne Oporow
🇵🇱Wroclaw, Poland
EMC INSTYTUT MEDYCZNY SA, EuroMediCare Szpital Specjalistyczny z Przychodnia - Dzial Farmacji
🇵🇱Wroclaw, Poland
Jerzy Rozciecha- Lexmedica
🇵🇱Wroclaw, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
🇵🇹Vila Nova de Gaia, Portugal
Centro Hospitalar e Universitário de Coimbra Serviço Gastrenterologia
🇵🇹Coimbra, Portugal
Centro Hospitalar de São João, EPE
🇵🇹Porto, Portugal
Dr. Carol Davila Central University Emergency Military Hospital
🇷🇴Bucharest, Romania
Centrul Medical Unirea srl
🇷🇴Bucharest, Romania
S.C Policlinica CCBR S.R.L
🇷🇴Bucuresti, Romania
S.C MedLife SA
🇷🇴Bucuresti, Romania
Delta Health Care srl
🇷🇴Bucuresti, Romania
S.C Euroclinic Hospital S.A
🇷🇴Bucuresti, Romania
Spitalul Clinic Colentina
🇷🇴Bucuresti, Romania
Institutul Clinic Fundeni
🇷🇴Bucuresti, Romania
Spitalul Clinic Judetean de Urgenta Cluj Napoca
🇷🇴Cluj-Napoca, Romania
Spitalul Clinic Judetean de Urgenta
🇷🇴Craiova, Romania
Cabinet Medical Dr. Fratila S.R.L
🇷🇴Oradea, Romania
S.C Pelican Impex S.R.L
🇷🇴Oradea, Romania
SAIH "Kemerovo Regional Clinical Hospital
🇷🇺Kemerovo, Russian Federation
SBIH of Nizhniy Novgorod region "Nizhniy Novgorod Regional Clinical Hospital n.a. N.A. Semashko"
🇷🇺Nizhniy Novgorod, Russian Federation
LLC Medicine Center SibNovoMed
🇷🇺Novosibirsk, Russian Federation
CDC Ultramed
🇷🇺Omsk, Russian Federation
State Budgetary Healthcare Institution "Penza Region Clinical Hospital n.a. N.N. Burdenko"
🇷🇺Penza, Russian Federation
LLC "Medinet"
🇷🇺Saint Petersburg, Russian Federation
LLC Medical Company "Hepatologist"
🇷🇺Samara, Russian Federation
Stavropol Regional Clinical Diagnostic Centre
🇷🇺Stavropol, Russian Federation
Clinical Health Center Zvezdara
🇷🇸Belgrade, Serbia
LLC "Polyclinic of ultrasonography 4D"
🇷🇺Stavropol, Russian Federation
Clinical Center " Dr Dragisa Misovic Dedinje"
🇷🇸Belgrade, Serbia
Clinical Center of Serbia
🇷🇸Belgrade, Serbia
General Hospital Sremska Mitrovica
🇷🇸Sremska Mitrovica, Serbia
Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica
🇸🇰Banska Bystrica, Slovakia
ENDOMED, s.r.o.
🇸🇰Vranov nad Toplou, Presov, Slovakia
Alian S.R.O
🇸🇰Bardejov, Slovakia
Fakultna nemocnica Nitra
🇸🇰Nitra, Slovakia
KM Management spol. s r.o.
🇸🇰Nitra, Slovakia
Gastro I, s.r.o.
🇸🇰Presov, Slovakia
GASTROENTEROLOG, s.r.o.
🇸🇰Nove Zamky, Slovakia
Accout Center s.r.o.
🇸🇰Sahy, Slovakia
Dr JP Wright Practice
🇿🇦Cape Town, Western Cape, South Africa
Johese Clinical Research: Unitas
🇿🇦Lyttelton, Centurion, South Africa
Lenasia Clinical Trial Centre
🇿🇦Johannesburg, Gauteng, South Africa
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Ms. Arawan Larplertsakul
🇹🇭Chiang Mai, Thailand
Gazi University Medical Faculty
🇹🇷Ankara, Turkey
Communal Non-commercial Enterprise of Kharkiv Regional Council Regional Clinical Hospital
🇺🇦Kharkiv, Ukraine
Antalya Training and Research Hospital
🇹🇷Antalya, Turkey
Kocaeli University Research and Training Hospital
🇹🇷Kocaeli, Turkey
Department of Propaedeutics of Internal Medicine Ivano-Frankivsk National Medical University
🇺🇦Ivano-Frankivsk, Ukraine
I.I.Mechnykov Dnipropetrovsk Regional Clinical Hospital
🇺🇦Dnipro, Ukraine
Municipal non-profit enterprise "Regional Clinical Hospital of Ivano-Frankivsk Regional Council", Ga
🇺🇦Ivano-Frankivsk, Ukraine
Communal Non-Commercial Enterprise City Clinical Hospital #13 of Kharkiv City Council
🇺🇦Kharkiv, Ukraine
Kyiv City Clinical Hospital N 1
🇺🇦Kyiv, Ukraine
Communal Non-Commercial Enterprise Lviv Clinical Hospital of Emergency Medical Care
🇺🇦Lviv, Ukraine
Kremenchuk first city hospital n.a. O.T. Bohaievskyi
🇺🇦Kremenchuk, Ukraine
Odesa regional clinical hospital, regional center of gastroenterology, surgical department
🇺🇦Odesa, Ukraine
Communal Noncommercial Enterprise Ye.Ye. Karabelesh Kherson City Clinical Hospital of Kherson City
🇺🇦Kherson, Ukraine
National Military Medical Clinical Center Main Military Clinical Hospital
🇺🇦Kyiv, Ukraine
A. Novak Transcarpathian Regional Clinical Hospital
🇺🇦Uzhgorod, Ukraine
Medical Clinical Investigational Center of Medical Center Health Clinic LLC
🇺🇦Vinnytsia, Ukraine
M.I. Pyrogov VRCH Dept of Gastroenterology M.I. Pyrogov VNMU
🇺🇦Vinnytsia, Ukraine
SRI of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU
🇺🇦Vinnytsia, Ukraine
Communal Institution City Clinical Hospital #6, Department of Gastroenterology
🇺🇦Zaporizhzhia, Ukraine
Barts Health NHS Trust - Whipps Cross University Hospital
🇬🇧London, Greater London, United Kingdom
Guys and St Thomas NHS Foundation Trust
🇬🇧London, Greater London, United Kingdom
Belfast Health and Social Care Trust Royal Victoria Hospital
🇬🇧Belfast, United Kingdom
Norfolk and Norwich University Hospitals NHS Foundation Trust
🇬🇧Norwich, Norfolk, United Kingdom
Yeovil Hospital NHS Foundation Trust
🇬🇧Yeovil, Somerset, United Kingdom
West Hertfordshire Hospitals NHS Trust Hemel Hempstead General Hospital
🇬🇧Hemel Hempstead, United Kingdom
Flint Clinical Research
🇺🇸Flint, Michigan, United States
West Central Gastroenterology d/b/a Gastro Florida
🇺🇸Clearwater, Florida, United States
Gastro Florida
🇺🇸Clearwater, Florida, United States
Life Medical Center & Research, INC
🇺🇸Miami Lakes, Florida, United States
Hospital Universitario La Paz
🇪🇸Madrid, Spain
KH der Barmherzigen Brüder Linz
🇦🇹Linz, Austria
Medical College of Wisconsin Clinical Trials Office
🇺🇸Milwaukee, Wisconsin, United States
Acibadem City Clinic University Hospital EOOD
🇧🇬Sofia, Bulgaria
Biomedica Research Group
🇨🇱Santiago, Chile
Centrum Medyczne Pratia Czestochowa
🇵🇱Czestochowa, Poland
IP Clinic
🇵🇱Lodz, Poland
Austin Health Gastroenterology Department
🇦🇺Heidelberg, Victoria, Australia
Private Educational Institution of Higher Education "Medical University REAVIZ"
🇷🇺Samara, Russian Federation
Kazan State Medical University
🇷🇺Kazan, Russian Federation
Federal state Budgetary Educational Institution of Higher Education "North-Western Medical University"
🇷🇺Saint Petersburg, Russian Federation
SPb SBIH "City Hospital # 40 of Kurortnyi region"
🇷🇺Sestroretsk, Russian Federation
CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 of KCC
🇺🇦Kharkiv, Ukraine
LLC "Multidisciplinary Medical Clinic "Anthurium"
🇷🇺Barnaul, Russian Federation
LLC Uromed
🇷🇺Smolensk, Russian Federation
Ruby Hall Clinic
🇮🇳Pune, Maharashtra, India