Brainwave Entrainment During Emergence
- Conditions
- Anesthesia, General
- Interventions
- Other: Binaural soundOther: Control
- Registration Number
- NCT05736510
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The investigators will compare whether there is a significant difference in the time required for general anesthesia recovery according to application of the binaural sound after surgery.
- Detailed Description
After entering the operating room, electrocardiogram, pulse oxygen saturation, blood pressure meter, and sedline are attached to start monitoring vital signs and patient state index (PSI). propofol and the remifentanil continuous infusion device is connected as close as possible to the catheter insertion site. Anesthesia is induced with total intravenous anesthesia (4 ng/mL of Remifentanil, 4 mg/mL of propofol). Rocuronium is administered after checking the patient's unconsciousness. When appropriate neuromuscular blocking is reached, tracheal intubation is performed. The anesthesia maintenance is performed to keep stable vital sign and PSI between 25 and 50. End-tidal carbon dioxide is controlled to be between 30 mmHg and 40 mmHg.
When the pneumoperitoneum ends, the propofol concentration is recorded (T0). The anesthesiologist in charge of anesthesia puts headphones on the patient and plays the allocated file. The allocated file is named the screening number. Depending on the allocated group, the audio file is binaural sound for the experimental group, and a silent file for the control group.
The anesthesiologist cannot know group allocation, since the length and size of files are the same. Thereafter, the target of PSI is to be between 40 and 50. If the Psi increases above 50, increase the propofol concentration by 0.5 mg/mL and record it. Train of four counts keep between 1 to 3 (moderate block). When the operation is ended, stop anesthetics administration, and record the time (T1). At the same time, the investigators reverse neuromuscular blocking using sugammadex (2mg/ kg).
When the anesthesiologist starts waking the patient up, call the patient's name (unify into "OOO, open your eyes."). The anesthesiologist lightly tap the patient's shoulder and avoid excessive sound or stimulation.
Record the time (T2) when the PSI reaches 50, the time when the patient opens eyes (T3), and the time (T4) when the extubation of endotracheal tube was done. T3-T1 is the time it took the patient to open his eyes (primary end point). Write the effect site concentration of propofol and remifentanil recorded for each time points.
The patient's sedline EEG data from the end of pneumoperitoneum until the patient's exit operating room is collected as raw data. The patient's blood pressure and heart rate are measured at each time points. The investigators evaluate sedation and agitation of the patients using Ramsay Sedation Scale.
In the post-anesthesia care unit, pain score (NRS 0-10), postoperative nausea vomiting, medication, and length of stay are investigated.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Female
- Target Recruitment
- 106
- Patients between 19 and 50 years of age who are scheduled to undergo laparoscopic salpingo-oophorectomy/ ovarian cystectomy
- Intellectual level to understand the procedures of the clinical trial
- Physical status classification of the American Society of Anesthesiology (ASA) 1-2 grades
- Patients with hearing loss or using hearing aids
- Patients who have been given narcotic painkillers or sedative drugs within a week.
- Alcohol-dependent or drug-dependent patients
- Patients with drug hypersensitivity to anesthetics
- Patients with arrhythmia, cardiovascular disease, impaired heart function, decreased circulatory blood flow
- Patients with liver failure
- Patients with other major medical or psychological disorder that will affect the treatment response
- Patients with claustrophobia or anxiety disorder
- Patients with organic brain disorders or other conditions that cannot be properly measured by PSI
- Patients who have been newly diagnosed with myocardial infarction, cerebral ischemic seizure, stroke, clinically significant coronary artery disease, or have undergone percutaneous carotid coronary dilatation or coronary bypass treatment within 6 months
- Patients with a history of epilepsy or seizures
- Patients with acute angle glaucoma
- Patients who deemed unsuitable for this clinical trial
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Binaural Binaural sound Exposed to binaural sound (40 Hz) from the end of pneumoperitoneum until the eyes are open Control Control Applied silent files from the end of pneumoperitoneum until the eyes are open
- Primary Outcome Measures
Name Time Method Eye opening time after the anesthetic infusion is terminated until 1 hour The time it takes to open patient's eyes in response to the voice after the anesthetic infusion is terminated.
- Secondary Outcome Measures
Name Time Method Extubation time after the anesthetic infusion is terminated until 1 hour The time it takes from the end of the anesthetic infusion to the extubation of endotracheal tube
Heart rate from the end of the anesthetic infusion to the exit of operating room until 1 hour Heart rate
delta band activity from the end of the anesthetic infusion to the exit of operating room until 1 hour delta band activity of electroencephalogram from Sedline data
beta band activity from the end of the anesthetic infusion to the exit of operating room until 1 hour beta band activity of electroencephalogram from Sedline data
Postoperative recovery score When the patient stay in post-anesthesia care unit up to 1 hour Postoperative recovery score (0-10; activity (0-2), respiration (0-2), circulation (0-2), consciousness level (0-2), and color (0-2); optimum score 10)
Pain score When the patient stay in post-anesthesia care unit up to 1 hour Postoperative pain score using numeric rating scale(0-10: 0, no pain; 10, worst possible pain)
Length of stay in post-anesthesia care unit From entering to exit the post-anesthesia care unit up to 2 hours Length of stay in post-anesthesia care unit
Medication When the patient stay in post-anesthesia care unit up to 1 hour Rate of administration of any medication in post-anesthesia care unit
Diastolic blood pressure from the end of the anesthetic infusion to the exit of operating room until 1 hour Noninvasive diastolic blood pressure
alpha band activity from the end of the anesthetic infusion to the exit of operating room until 1 hour alpha band activity of electroencephalogram from Sedline data
Systolic blood pressure from the end of the anesthetic infusion to the exit of operating room until 1 hour Noninvasive systolic blood pressure
theta band activity from the end of the anesthetic infusion to the exit of operating room until 1 hour theta band activity of electroencephalogram from Sedline data
Rate of postoperative nausea and vomiting When the patient stay in post-anesthesia care unit up to 1 hour Rate of postoperative nausea and vomiting
Mean blood pressure from the end of the anesthetic infusion to the exit of operating room until 1 hour Noninvasive mean blood pressure
Ramsay Sedation Scale When the end of anesthesia within 5minutes The degree of patient's sedation or agitation (1 to 6: 1 means "Patient is anxious and agitated or restless, or both"; 6 means "Patient exhibits no response")
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of