Health Care Utilisation Among Survivors of Childhood Acute Lymphoblastic Leukaemia

Completed

• Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma
• Interventions: Other: Diagnosis of and treatment for Acute lymphoblastic leukaemia in childhood

• Registration Number: NCT03985826
• Lead Sponsor: University of Aarhus

Brief Summary

Improved understanding of the long-time healthcare utilisation of childhood cancer survivors is relevant as it can be seen as a proxy for the population's morbidity.

The investigators will conduct a historic population-based matched cohort study using Danish nationwide registry data. Eligible children are children 1.0-17.9 years diagnosed with Acute lymphoblastic leukaemia (ALL) in Denmark from 1994 till 2016. The primary outcome is yearly contact rates to primary healthcare.

Detailed Description

Acute lymphoblastic leukaemia (ALL) is the most frequent single form of cancer in children accounting for 40-45 new cases every year in Denmark. Over the past decades, advances in treatment have led to an increasing number of children who survive cancer and more than 80% of children with ALL now become long-term survivors. This means a growing population of childhood ALL survivors. In survivors, the cancer itself and treatment late-effects can lead to ongoing health care use.

Register studies of long-term survivors of childhood cancer have shown an increased risk of hospitalisation compared to the general population. It is mentioned in many of the studies that contact rates could be underestimated when looking at hospital contacts only.

The literature about non-hospital-based contacts with a doctor in childhood cancer survivors is scarce.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2019-06
• Study First Submitted: 2019-06-11
• Study First Submitted QC: 2019-06-13
• Study First Posted: 2019-06-14
• Study Start: 2019-09-01
• Primary Completion: 2019-11-30
• Study Completion: 2019-11-30
• Last Update Submitted: 2020-12-01
• Last Update Posted: 2020-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7348

Inclusion Criteria

• B-precursor ALL and T-ALL enrolled in the NOPHO ALL-92, ALL-2000 and ALL-2008 trials.
• Treated at one of the four Danish paediatric oncology departments
• Age group 1.0-14.9 for the NOPHO ALL-92 and ALL-2000 trials. Age group 1.0-17.9 for the NOPHO ALL-2008 trial.
• Completed maintenance therapy in the time period form 01.01.1997 till 31.12.2016

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Exclusion Criteria

• Children with Down syndrome

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Childhood ALL survivors	Diagnosis of and treatment for Acute lymphoblastic leukaemia in childhood	The cohort of childhood ALL survivors will be identified in the Danish part of the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL-Register .

Primary Outcome Measures

Name	Time	Method
The yearly contact rate to general practice for ALL survivors and controls	1-20 years follow-up	Analysing longitudinal health care data with analysis of both first and recurrent events

Trial Locations

Locations (1)

Department of Public Health; 🇩🇰 Aarhus C, Denmark