Health Care Utilisation Following Childhood Acute Lymphoblastic Leukaemia: A Matched Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7,348
- 试验地点
- 1
- 主要终点
- The yearly contact rate to general practice for ALL survivors and controls
研究概览
简要总结
Improved understanding of the long-time healthcare utilisation of childhood cancer survivors is relevant as it can be seen as a proxy for the population's morbidity.
The investigators will conduct a historic population-based matched cohort study using Danish nationwide registry data. Eligible children are children 1.0-17.9 years diagnosed with Acute lymphoblastic leukaemia (ALL) in Denmark from 1994 till 2016. The primary outcome is yearly contact rates to primary healthcare.
详细描述
Acute lymphoblastic leukaemia (ALL) is the most frequent single form of cancer in children accounting for 40-45 new cases every year in Denmark. Over the past decades, advances in treatment have led to an increasing number of children who survive cancer and more than 80% of children with ALL now become long-term survivors. This means a growing population of childhood ALL survivors. In survivors, the cancer itself and treatment late-effects can lead to ongoing health care use.
Register studies of long-term survivors of childhood cancer have shown an increased risk of hospitalisation compared to the general population. It is mentioned in many of the studies that contact rates could be underestimated when looking at hospital contacts only.
The literature about non-hospital-based contacts with a doctor in childhood cancer survivors is scarce.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Year 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •B-precursor ALL and T-ALL enrolled in the NOPHO ALL-92, ALL-2000 and ALL-2008 trials.
- •Treated at one of the four Danish paediatric oncology departments
- •Age group 1.0-14.9 for the NOPHO ALL-92 and ALL-2000 trials. Age group 1.0-17.9 for the NOPHO ALL-2008 trial.
- •Completed maintenance therapy in the time period form 01.01.1997 till 31.12.2016
排除标准
- •Children with Down syndrome
结局指标
主要结局
The yearly contact rate to general practice for ALL survivors and controls
时间窗: 1-20 years follow-up
Analysing longitudinal health care data with analysis of both first and recurrent events
次要结局
未报告次要终点