NL-OMON33557招募中不适用
The contribution of glutamine to citrulline and arginine synthesis, when alanyl-glutamine is supplied in an enteral dose of 0.5 g/kg, in critically ill patients. - Dipep human IC
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •*Age: > 18 and < 80 years
- •*BMI > 18,5 and < 35
- •*Ability to tolerate enteral nutrition, provided by postpyloric tube, meeting full protein/energy requirements based on indirect calorimetric measurements
- •*Expected ICU or medium care stay of a minimum of 5 days
- •*Any ICU patient who is considered *stable*:
- •* Hemodynamics: no new vasoactive medication during 24 hrs preceding inclusion, maximum dose of vasoactive medication < 5 mg/kg/min
- •* Respiration: PaO2/FiO2 ratio > 200, PEEP < 15 cm H2O, when on respiration
- •*Having obtained his/her or his/her legal representative*s informed consent
排除标准
- •* Admission after elective surgery
- •* Pregnancy
- •* Liver failure, defined by bilirubin levels > 100
- •* Kidney failure, represented by increase in serum creatinine levels to > 100 umol/l, in the absence of primary underlying renal disease, or oliguria, defined as urine output < 20 ml/hour in the previous 6 weeks
- •* Urea cycle defects
- •* Chronic corticosteroids use ( > 7. mg/ day > 3 weeks)
- •* Bowel malabsorption possibly interfering with intestinal absorptive function, e.g. celiac disease, crohn*s disease, presence of fistulas, major intestinal malabsorption disorder, or short bowel syndrome
- •* Parenteral feeding
- •* Use of medium chain triglycerides or glutamine/citrulline supplements
研究者
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