Steroid Before Thyroidectomy

Not Applicable

Completed

• Conditions: Thyroid Surgery for Benign Disease
• Interventions: Drug: Placebo; Drug: Dexamethason Helvepharm ®

• Registration Number: NCT00619086
• Lead Sponsor: University of Bern

Brief Summary

We evaluated the effects of giving a single dose of steroid before thyroid surgery in a single institutional, double-blinded, randomized controlled trial. Postoperative nausea, pain, and vocal function were significantly improved after steroid administration compared to controls.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-11
• Study Completion: 2007-06
• Study First Submitted: 2008-02-07
• Study First Submitted QC: 2008-02-19
• Study First Posted: 2008-02-20
• Status Verified: 2008-06
• Last Update Submitted: 2008-06-06
• Last Update Posted: 2008-06-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

• Patients undergoing thyroid surgery for benign disease

Exclusion Criteria

• Depression
• Chronic pain disorder
• Insulin dependent diabetes mellitus
• History of PONV
• Pregnancy
• Age < 18 years
• Received antiemetic therapy within 48 hours

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
A, 1	Placebo	Placebo 45 minutes prior to surgery
A, 2	Dexamethason Helvepharm ®	8 mg Dexamethasone 45 minutes prior to surgery

Primary Outcome Measures

Name	Time	Method
Nausea	0-72 hours postoperative

Secondary Outcome Measures

Name	Time	Method
Pain, vocal function	0-72 hours postoperative

Trial Locations

Locations (1)

Department of visceral- and transplant surgery; 🇨🇭 Bern, Switzerland