Development of biomarkers for phenotype classification toward precision medicine in obstructive sleep apnea
Not Applicable
Completed
- Conditions
- Diseases of the nervous system
- Registration Number
- KCT0004885
- Lead Sponsor
- Chonnam National University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 2000
Inclusion Criteria
Teens and adults over the age of 15
Patients with suspected sleep apnea with Apnea-hypopnea index 5 or higher on polysomnography
A person who voluntarily agrees in writing to participate in this study
Exclusion Criteria
Pregnant women, women who may be pregnant, and women who breastfeed
Patients with central sleep apnea or other sleep disorders such as insomnia, restless leg syndrome, lethargy, circadian disorder, and event sleep before medical treatment
Patients with diseases of moderate or higher lung disease, neuromuscular disease, heart failure, etc., which may decrease the accuracy of sleep polysomnography
Patients who do not agree to surveys and polysomnography
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Biomarker : C-reactive protein, Interleukin-6, Interleukin-8, Interleukin-10, tumor necrosis factor-a, Intercellular adgesion-1, Vascular cell adgesion-1, L-selectin, HemoglovinA1c, Uric acid, Erythroprotein, Leptin, Resistin;Obesity related factor : height, weight, neck circumference, Body Mass Index;Facial anatomy : cephalometry, neck computed tomography;drug-induced sleep endoscopy;rain imaging : MRI/A(Magnetic resonance imaging/Angiography), PET(Positron emission tomography) or SPECT(Single Photon emission computed tomofraphy);VFSS test;Data of surgery on General Anesthesia : ABGA(arterial blood gas anaylyhsis), Catecholamine leve ect.
- Secondary Outcome Measures
Name Time Method polysomnography;race, age, gender, ingabitation, religionetc, General health conditions;sleep related symptom, cognitive dysfunction, mood symptoms, Difficulties in daily life, Functional performance disorder