Comparison of the Effects of Postoperative Oral Flurbiprofen (0.25%) Spray and Ice Cream on Analgesia and Voice Quality in Patients Undergoing Thyroidectomy

Patients undergoing thyroidectomy will be randomized into three groups using a card selection method (this method will be used to ensure that patients' personal medication/food preferences do not affect the randomization). The first group will receive one puff of oral flurbiprofen (0.25%) spray (for pain palliation) at 5 hours post-operatively; the second group will receive 105 ml of frozen ice cream at 5 hours post-operatively; and the third group will receive one puff of spray prepared with drinking water at 5 hours post-operatively as a placebo.

At 6 hours post-operatively, voice analysis will be performed using Praat voice analysis (University of Amsterdam / Netherlands) and analgesia status will be analyzed using a visual analog scale to compare the two methods with each other and with the placebo.

Routine proton pump inhibitor, analgesic, and antiemetic treatments will be administered post-operatively. The patient's clinical follow-up will be documented by the lead investigator and the associate investigator. A case report form will be completed for each registered patient and signed by the lead investigator or co-investigator. This will also apply to records of patients who do not complete the study. If a patient withdraws from the study, the reason will be recorded on the case report form. If a patient withdraws from the study due to a treatment-limiting adverse event, every effort will be made to clearly document the outcome. All forms will be completed legibly with indelible ink. Corrections will be initialed and dated by the lead investigator or co-investigator. The investigator is responsible for the accuracy of the data transferred to the forms and will sign them to demonstrate their consistency with the recorded data.

Patients participating in the study will have their detailed pre-operative allergic status checked and will undergo close vital sign monitoring during the procedure. Volunteer patients may withdraw from the study at any stage at their own request.

This study will be conducted in full compliance with the principles of the "Helsinki Declaration" and the laws and regulations of our country, and will also adhere strictly to the principles outlined in good clinical practice.