Effect van verwarmde oxaliplatin op acute perifere neuropathie klachten bij patienten die aanvullend of voor een gevorderde of uitgezaaide darmkanker behandeld worden met oxaliplatin houdende chemotherapie.
Recruiting
- Conditions
- acute peripheral neuropathy colorectal cancer oxaliplatin induced complaints
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 16
Inclusion Criteria
1. Patients treated adjuvant or palliative with oxaliplatin for a colon-rectal carcinoma who suffer from an acute peripheral neuropathy after the first treatment with oxaliplatin containing regime;
2. Living within a radius of 30 km from the hospital;
Exclusion Criteria
1. Presence of diabetes mellitus, renal failure, alcoholism, vitamin B 12 deficiency, other neoplasm or HIV;
2. Previous treatment with a neurotoxin cytostatic drug;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Decrease of the acute peripheral neuropathy complaints with 1 point or more on the four points scale of the Total Neuropathy Score;<br /><br>2. Changes in quality of life (cancer related and symptom related) in the period after infusion of heated oxaliplatin in comparison with the period after infusion of oxaliplatin on roomtemperature.
- Secondary Outcome Measures
Name Time Method Respons rate by CT scan and changes of CEA (tumormarker).