Arterial and venous uptake pharmacokinetics of inhaled sevoflurane
Completed
- Conditions
- Het onderzoek heeft geen betrekking op aandoeningenTechniques in anesthesiology
- Registration Number
- NL-OMON32096
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Age 35-70 years
Scheduled for elective neurosurgical procedures where an arterial and central venous line will be applied.
Expected surgery time > 2 hours
Informed consent
Exclusion Criteria
Anemia (Hb < 6.0 mmol/l)
Hepatic or terminal renal failure
Use of adenosine triphosphate sensitive potassium channel antagonists, such as sufonylurea derivates, diazoxide or theophylline
Unfulfilled anesthesia study protocol
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary endpoint consists of evaluation of the pharmacokinetics of arterial<br /><br>and venous uptake of inhaled sevoflurane by gas chromatography.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The second endpoint is defined as determination of the end-tidal fraction ratio<br /><br>of inhaled sevoflurane over time. </p><br>