Dissection of the blood B cell compartment in affected and non-affected family members of patients with Common Variable Immunodeficiency (CVID). - Blood B cell compartment in CVID families

Radboud Universitair Medisch Centrum0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

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•In order to be eligible to participate in this study, a subject must meet all of the following criteria:;Inclusion criteria for the index case
•- ESID-defined probable or possible CVID patients with or without positive family history for CVID according to the ESID registry (2014) criteria;Inclusion criteria for the family members
•- Siblings (> 16 years of age), parents and grandparents
•- Each participating family member will have to provide informed consent in order for the family to be eligible for inclusion.

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•- ESID-defined CVID patients having a known mono-genetic cause of CVID disease
•- ESID-defined CVID patients having another mono-genetic disorder not obvious related to CVID
•- ESID-defined CVID patients having a chromosomal defect
•- Infections within 3 months prior to this study
•- Surgeries within 6 months prior to this study
•- Vaccinations within 3 months prior to this study
•- Family members having significant disorders, including other immunodeficiency other than CVID, cancer, oral steroid therapy or any history of any comorbidity that, in the opinion of the investigator, might confound the results of the study

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