Effects of particle release from knee spacers made of zirconium containing PMMA bone cement
Recruiting
- Conditions
- M89.5Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and graftsOsteolysisadverse reactions to metal debris (ARMD), i.e. particles and corrosion products, released from orthopaedic implants, including bone cement spacersperiprosthetic osteolysesperiprosthetic infectionUnspecified complication of internal orthopaedic prosthetic device, implant and graftT84.7T84.9
- Registration Number
- DRKS00030490
- Lead Sponsor
- niversitätsklinikum Greifswald
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
patients of all sexes who receive an articulating or a static knee spacer at one of the study centers
and give written consent to participate in this study
Exclusion Criteria
age < 18 years, lack of written informed consent, lacking capacity of consent
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms link zirconium-containing PMMA spacers to reduced periprosthetic osteolysis in joint infections?
How does zirconium-containing PMMA bone cement compare to standard spacers in managing periprosthetic infections and osteolysis?
Are there specific biomarkers that predict patient response to zirconium-containing PMMA spacers in orthopedic infections?
What are the potential adverse events associated with zirconium-containing PMMA spacers in knee revision surgeries?
What alternative compounds or combination therapies are being explored for managing adverse reactions to orthopedic implant debris?