Measuring the Change of Intra-abdominal Pressures of the Intensive Care Unit Patients During the Spontaneous Breathing Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- To evaluate the patterns of change of IAP during SBT
研究概览
简要总结
Increased intra-abdominal pressure (IAP) affects pulmonary dynamics. However, little is studied whether pulmonary dynamics affects IAP. We hypothesize that the change of IAP can also reflect the change of pulmonary dynamics. In this study, we choose patients who received spontaneous breathing trial to answer the hypothesis.
详细描述
During the weaning process, we tapered down the respiratory support from mechanical ventilation and recruited respiratory muscles to work. Previous study showed that transdiaphragmatic pressure was increasing while pressure support was reducing. However, the transdiaphragmatic pressure required invasive procedure to measure and not used frequently in weaning. IAP reflects the pleural pressure. If the PEEP is not changed, change of IAP is largely due to change of transpulmonary pressure.
Study Aim:
- To evaluate the patterns of change of IAP during SBT
- To predict success of SBT by the change of IAP
- To predict weaning outcome by the change of IAP
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients with endotracheal intubation in the intensive care unit
- •The clinical condition is considered to prepare for weaning assessment
排除标准
- •tracheostomy
- •severe heart failure, heart disease or arrhythmia
- •upper airway obstruction related respiratory failure
- •poor cooperation due to agitation
- •no foley catheter in place or had been removed
- •baseline IAP above 20 mmHg
结局指标
主要结局
To evaluate the patterns of change of IAP during SBT
时间窗: 30min, 60min, 120min
30min, 60min, 120min during a 2-hr SBT
次要结局
- To predict success of SBT by the change of IAP(0 min, 30 min, 120 min)
- To predict weaning success by the change of IAP(0 min, 30 min, 120 min)