Does Sedation Influence on Delirium and Post-traumatic Stress-disorder as a Result of Hospitalization in Intensive Care?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 248
- 试验地点
- 2
- 主要终点
- Sedation level and Delirium
研究概览
简要总结
The aim of this study is to investigate if sedation of Intensive Care Unit (ICU) patients influences the development of delirium during their ICU stay and if incidences of delirium have an impact on the development of Post-traumatic Stress-Disorder (PTSD).
Hypothesis 1:
Patients who are minimally sedated, remember staying in ICU and experiences fewer episodes of delirium than patients that are heavily sedated
Hypothesis 2:
Former delirious patients are more likely to develop PTSD
Hypothesis 3:
Delirium decreases health-related quality (HRQoL) of life after discharge
详细描述
Background:
It is known that ICU patients that experience delirium have longer hospital stay, higher mortality and morbidity. Other studies indicate that PTSD, dementia or depression may emerge after discharge from hospital.
Methods according to hypothesis 1:
During ICU stay: Measure sedation level & delirium. First follow-up 1-2 weeks after ICU: Memories
Analyses:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU-stay > 48 hours
排除标准
- •Severe brain trauma
- •Non-Danish-speaking
- •Age < 18 years
- •Death (only hypothesis 2 and 3 in the study)
结局指标
主要结局
Sedation level and Delirium
时间窗: At least twice a day while in the ICU
Sedation assessed with RASS and delirium assessed with the CAM-ICU by the nurses at the ICU
次要结局
- Health-related quality of life(2 and 6 month after ICU-discharge)
- Post Traumatic Stress Disorder(2 and 6 month after ICU-discharge)