The Significance of Preoperatively Calculated HALP Score in Differentiating Complicated Acute Appendicitis in Patients With Acute Appendicitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 411
- 试验地点
- 1
- 主要终点
- Preoperative HALP Score
研究概览
简要总结
Acute abdomen is a frequently encountered clinical condition that can be fatal if not diagnosed early. Acute appendicitis is one of the causes of acute abdomen and is the most common clinical condition leading to acute abdomen worldwide. Therefore, early diagnosis is crucial. Delays in diagnosis can lead to the complication of appendicitis and an increase in its complications, further worsening the clinical picture and raising morbidity and mortality rates.
In patients diagnosed with acute appendicitis, distinguishing between complicated and uncomplicated appendicitis is vital for treatment planning. The evaluation of patients' laboratory and radiological findings are widely used methods in clinical practice for this differentiation.
Recent studies have shown the HALP score has become a new prognostic biomarker in the literature, used to predict a range of clinical outcomes in various neoplasms. To date, the HALP score has been used to evaluate outcomes and prognosis in gastric, colorectal, bladder, prostate, and other cancers, as well as in many other diseases.
The purpose of this study is to determine the clinical impact of using the preoperatively calculated HALP score, derived from blood parameters, in the diagnosis, detection, and treatment of complicated acute appendicitis cases in the preoperative period without the need for additional diagnostic methods.
详细描述
*Aim of the Study Acute abdomen is a frequently encountered clinical condition that can be fatal if not diagnosed early. Numerous diseases can cause acute abdomen, making accurate and rapid diagnosis extremely important. Acute appendicitis is one of the causes of acute abdomen and is the most common clinical condition leading to acute abdomen worldwide.
In a study by Addiss et al., the incidence of acute appendicitis was approximately 233 per 100,000 people. Although slightly more common in males, there is a lifetime risk of about 7%.
Therefore, early diagnosis is crucial. Delays in diagnosis can lead to the complication of appendicitis and an increase in its complications, further worsening the clinical picture and raising morbidity and mortality rates.
The reported incidence of complicated appendicitis and its complications in various studies ranges from approximately 20% to 30%. This significant rate increases the risk of morbidity and mortality. Thus, early diagnosis and treatment of appendicitis are of great importance to prevent the development of complications.
In patients diagnosed with acute appendicitis, distinguishing between complicated and uncomplicated appendicitis is vital for treatment planning. The evaluation of patients' laboratory and radiological findings are widely used methods in clinical practice for this differentiation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Being over 18 years of age
- •Having undergone surgical treatment for a diagnosis of acute appendicitis (Laparoscopic or conventional open surgery)
- •Patients with no missing data in their records
排除标准
- •Patients under 18 years of age
- •Cases of uncomplicated acute appendicitis diagnosed but treated medically
- •Patients with incomplete data
- •Those with chronic kidney and liver failure
- •Patients with liver diseases such as Wilson's disease or alpha-1 antitrypsin deficiency
- •Individuals with hematological malignancies like ALL or AML
- •Patients with genetic bleeding disorders such as hemophilia
结局指标
主要结局
Preoperative HALP Score
时间窗: 2020,01,01-2025,01,01
Manually calculated HALP score from routinely obtained preoperative blood samples of acute appendicitis cases, can be helpful for preoperatively determining complicated acute appendicitis cases without additional cost.
次要结局
- Preoperative cut off value levels of HALP score to determine complicated acute appendicitis(2020,01,01-2025,01,01)
研究者
Mehmet Buğra Bozan
Professor, Associate
Elazıg Fethi Sekin Sehir Hastanesi