Salivary Cortisol As a Biomarker in Patients with Temporomandibular Disorder

Recruiting

• Conditions: Temporomandibular Joint Disorder

• Registration Number: NCT06874868
• Lead Sponsor: University of Coimbra

Brief Summary

t is recognized that cortisol, a hormone produced by the adrenal glands, is a marker that is elevated in patients with psychological disorders, particularly anxiety. On the other hand, Temporomandibular Disorders (TMD) are a condition with a multifactorial etiology, in which emotional disturbances play a crucial role.

Therefore, the aim of this study is to evaluate whether patients with TMD have higher levels of salivary cortisol compared to the general population.

Initially, an assessment will be conducted using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol to determine whether the patient suffer of any kind of Temporomandibular Disorder. Based on the results, individuals will be classified into two groups: the study group, consisting of patients with TMD, and the control group, composed of individuals without the disorder.

Those who agree to participate will be required to sign an informed consent form. Subsequently, a saliva sample will be collected for analysis.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-09
• Study Start: 2024-09-15
• Primary Completion: 2024-09-20
• Study First Submitted: 2025-03-07
• Study First Submitted QC: 2025-03-07
• Last Update Submitted: 2025-03-07
• Study First Posted: 2025-03-13
• Last Update Posted: 2025-03-13
• Study Completion: 2025-05-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients who attend the dental clinic of the Faculty of Medicine of University of Coimbra

Exclusion Criteria

• Pregnant women, minors and non-autonomous individuals

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Salivary cortisol concentration	One day	The collection should be performed at the time specified by the physician and at least 30 minutes after the ingestion of solid or liquid foods. A collection tube must be obtained from the laboratory, and the following steps should be followed: Remove the smaller tube from the collection kit. Open the tube, take out the swab, and place it in the mouth. Gently chew the swab for approximately 1 minute or until swallowing the accumulated saliva becomes unavoidable.; Return the swab to the smaller tube, ensure it is securely sealed, and then place it inside the larger tube.; Immediately freeze the sample.

Trial Locations

Locations (1)

Faculty of Medicine of University of Coimbra; 🇵🇹 Coimbra, Portugal