Creatine monohydrate supplementation in young, healthy vegetarian adults and its effect on brown adipose tissue activatio
- Conditions
- energiemetabolismeMetabolism
- Registration Number
- NL-OMON46813
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 23
- Male or female;
- Caucasian;
- 18 to 30 years of age;
- Consuming a vegetarian diet;
- BMI 20-25 kg/m2.
- Not meeting all inclusion criteria;
- Non-vegetarian diet;
- Excessive alcohol and/or drug abuse;
- Significant allergies or intolerances concerning the study products;
- Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
- Medication use known to hamper subject*s safety during the study procedures; *
- Subjects with contra-indications for MRI and/or PET-CT;
- Subjects who do not want to be informed about unexpected medical findings; *
- Subjects who do not want that their treating physician to be informed;
- Co-morbidities to which the intervention or program that may pose as a complicating factor;
- Inability to participate and/or complete the required measurements;
- PET-CT scan in the preceding year.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>SUVmean and SUVmax of brown adipose tissue depots as determined by PET-MR using<br /><br>the 18F-FDG tracer.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Diet-induced thermogenesis;<br /><br>- Ex vivo mitochondrial respiration in skeletal muscle;<br /><br>- In vivo mitochondrial function in skeletal muscle<br /><br>- Blood and muscle creatine;<br /><br>- Blood metabolites;<br /><br>- Body composition;<br /><br>- Metabolic substrate handling;<br /><br>- Molecular pathways and gene transcription putatively responsible for<br /><br>triggering improved mitochondrial health and function.</p><br>