Evaluation of the Furosemide Stress Test to Predict Successful Liberation From Renal Replacement Therapy in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Successful liberation of RRT within 72 hours after FST
研究概览
简要总结
The proposed study will evaluate if a standardised dose of furosemide administered in the 12 hours after RRT liberation can predict successful liberation in critically ill patients. The dose that will be administered is in accordance with the prescribing information.
详细描述
Response to furosemide administration is commonly used in clinical practice to assess a patient's potential for RRT liberation. However, this administration is not standardized and practices varies greatly. Rapid recognition of unsuccessful RRT liberation is crucial to avoid further complications such as fluid overload or acid-base and electrolyte disorders. The FST corresponds to the intravenous administration of 1 mg/kg (1.5 mg/kg in previously exposed patients) of furosemide and the assessment of resulting diuresis in the following two hours. FST is able to predict progression from AKI stage I and II to stage III with a high sensitivity (87.1%) and specificity (84.1%), area under the ROC curve 0.87. However, the ability of FST to predict RRT liberation has never been formally assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving continuous or intermittent RRT for AKI
- •Having an indwelling urinary catheter
- •Clinical decision by physician in charge to attempt RRT liberation
- •lnformed consent signed by the patient himself / legal representative or authorization received from independent physician
排除标准
- •Electrolyte disturbances or hemodynamic instability precluding the use of furosemide (sodium > 155 mmol/L and/or potassium < 3.0 mmol/L and/or metabolic alkalosis > 7.50 and/or mean arterial pressure < 60 mmHg)
- •Known furosemide allergy
- •Urine output ≥ 100 mL/h for at least two hours
- •Recent (< 24 hours) FST
- •Known end-stage chronic renal disease at ICU admission
- •Withdrawal of life support decision taken before inclusion
- •Patient already participating in conflicting research study
- •Patient having already participated in this current study
- •Any other contraindication of furosemide
研究组 & 干预措施
Critically ill patients undergoing RRT
Patients admitted to participating ICU and receiving renal replacement therapy.
干预措施: Furosemide stress test (Drug)
结局指标
主要结局
Successful liberation of RRT within 72 hours after FST
时间窗: within 72 hours
No renal replacement therapy administered
次要结局
- Successful liberation of RRT at hospital discharge(At time of hospital discharge, assessed up to 90 days post inclusion)
- Successful liberation of RRT at ICU discharge(At time of ICU discharge, assessed up to 90 days post inclusion)
- Adverse events associated with the intervention(within 6 hours)
研究者
Antoine Schneider
Doctor
Centre Hospitalier Universitaire Vaudois