NCT04464811Unknown不适用
Furosemide Stress Test for the Prediction of Acute Kidney Injury Severity in Acute Heart Failure Patients
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 257
- 试验地点
- 1
- 主要终点
- Serum creatinine
研究概览
简要总结
This study is aim to study the changes of serum creatinine levels at 72 hours after admission in patients with acute heart failure who has diuretic resistance compared to those who do not have diuretic resistance from furosemide stress test
详细描述
This study is an observational prospective study to demonstrate a prognosis of acute heart failure patients who have diuretic resistance compared to those who do not have diuretic resistance from furosemide stress test. The primary outcome is changes of serum creatinine levels at 72 hours compared to baseline values at the time of admission.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years
- •Diagnosis of acute heart failure which is defined by 2 of the 3 following features: ≥2+ leg edema, jugular venous pressure >10 cm from physical examination or central venous pressure >10 mmHg, and bilateral pulmonary edema or bilateral pleural effusion from chest radiography
- •Patients consent to participate into the study
排除标准
- •Patients who receive furosemide ≥500 mg/day or hydrochlorothiazide ≥100 mg/day or spironolactone ≥100 mg/day or tolvaptan of any doses
- •Patients who have systolic blood pressure <100 mmHg or who need vasoactive drugs inotropic agents (except dobutamine)
- •Patients with intravascular volume depletion from clinical evaluation
- •Patients with chronic kidney disease stage 5 (estimated glomerular filtration rate <15 ml/min/1.73 m2) or patients who receive maintenance dialysis
- •Patients who require renal replacement therapy at the time of admission
- •Patients whom diagnosed hypertrophic obstructive cardiomyopathy, severe valvular stenosis or complex congenital heart disease
- •Patients with sepsis or systemic infection
- •Pregnant women
- •Patients who have history of furosemide, spironolactone or hydrochlorothiazide allergy
结局指标
主要结局
Serum creatinine
时间窗: Seventy-two hours after admission
Changes in serum creatinine from baseline
次要结局
- Serum creatinine(Day 7 of hospital admission)
- Requirement for renal replacement therapy(During hospital admission period)
- Length of hospital admission(During hospital admission period)
- Changes of the stage of heart failure defined by New York Heart Association (NYHA) classification(Day 7 and 28 after hospital admission)
- Numbers of hospital readmission(Month 1 and 3 after hospital discharge)
- Mortality rate(Day 7 and 28 after hospital admission)
研究者
Kajohnsak Noppakun
Assistant Professor of Medicine
Chiang Mai University
研究点 (1)
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