Furosemide Stress Test as a Marker of Postoperative Kidney Allograft Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 360
- 试验地点
- 1
- 主要终点
- Urine output
研究概览
简要总结
Furosemide is an old drug that has been used frequently in the postoperative period of kidney transplantation, aiming to achieve adequate urine output. There is no previous study that directly evaluate the urine response to standardized dose of furosemide in the postoperative period. The objective is to measure the urine output after standardized dose of furosemide is delivered, as a biomarker to predict the graft function in perioperative period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Deceased donor kidney transplantation at KCMH
- •informed consent is accepted
排除标准
- •Known allergy to furosemide
- •Surgical complication of allograft
- •Urgently needed for dialysis (refractory hypervolemia, uremic symptoms, and hyperkalemia)
研究组 & 干预措施
Furosemide
Single dose of furosemide 1.5 mg/kg intravenously will be given to all participants at 3 hours post-reperfusion of kidney allograft.
Urine output will be recorded hourly for 6 hours.
干预措施: Furosemide Injection (Drug)
结局指标
主要结局
Urine output
时间窗: 6 hours
Urine output per hour (milliliters/hour) after furosemide injection
次要结局
- Delayed graft function(7 days)
- Creatinine reduction ratio(At postoperative day 0,7 and 14)
研究者
Suwasin Udomkarnjananun
Suwasin Udomkarnjananun, M.D.
King Chulalongkorn Memorial Hospital