NCT03861884招募中不适用
Cognition and NeuroImaging in neuroDegenerative Disorders (CogNID)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 125
- 试验地点
- 2
- 主要终点
- Neurocognitive scales on Birmingham Cognitive Screen (BCoS) Scores
研究概览
简要总结
This prospective study aims:
- to compare cognitive performance in different clinical groups of participants with mild cognitive impairment (MCI) or mild dementia [Alzheimer's Disease (AD), Vascular Cognitive Impairment (VCI) and Fronto-temporal Dementia (FTD)] to determine whether scores reveal differential profiles between the groups,
- to demonstrate differences in imaging markers between different dementia syndromes and healthy volunteers using ultra high-field MRI at 7T.
详细描述
The imaging arm of the study include:
- to demonstrate differences in brain iron levels between different dementia syndromes and healthy volunteers using ultra high-field MRI, quantitative susceptibility mapping (QSM) at 7T.
- to demonstrate variations in the resting oxygen usage as an important biomarker to discriminate between different dementia syndromes.
- to demonstrate cerebral blood flow changes in the brain, particularly in the hippocampus region, and its correlation with different dementia syndromes using Arterial Spin Labelling MRI technique.
- to demonstrate increased blood brain barrier leakage in the brain, particularly in the hippocampus region, and its correlation with Alzheimer's Disease (AD) and Vascular Cognitive Impairment (VCI) using a new dynamic contrast-enhanced MRI (DCE-MRI) technique.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Ability to give informed consent.
- •Either pathological, genetic or imaging biomarker evidence to suggest Fronto-temporal Lobar Degeneration, Alzheimer's Disease or Vascular Cognitive Impairment, or defined clinical diagnoses.
排除标准
- •Lack of mental capacity to consent to study involvement.
- •Not speaking English before age 5 years.
- •Learning disability.
- •MRI contraindications
结局指标
主要结局
Neurocognitive scales on Birmingham Cognitive Screen (BCoS) Scores
时间窗: Through study completion (an average of one year)
cognitive sub scores in relation to clinical phenotype
次要结局
- Structural imaging changes on MRI at 3T(Through study completion (an average of one year))
- Susceptibility weighted mapping at 7T(Through study completion (an average of one year))
研究者
研究点 (2)
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